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B1J4W2 (TPMT_PSEPW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thiopurine S-methyltransferase
EC=2.1.1.67
Alternative name(s):
Thiopurine methyltransferase
Gene names
Name:tpm
Ordered Locus Names:PputW619_1479
OrganismPseudomonas putida (strain W619) [Complete proteome] [HAMAP]
Taxonomic identifier390235 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812

Subcellular location

Cytoplasm By similarity HAMAP MF_00812.

Sequence similarities

Belongs to the methyltransferase superfamily. TPMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthiopurine S-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Thiopurine S-methyltransferase HAMAP MF_00812
PRO_1000134078

Sites

Binding site101S-adenosyl-L-methionine By similarity
Binding site451S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site661S-adenosyl-L-methionine By similarity
Binding site1231S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
B1J4W2 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: F5AB514261332215

FASTA21524,270
        10         20         30         40         50         60 
MEAAFWHQKW ADNQIGFHQA QANPYLQRYW PGLGLAAGSR VLVPLCGKSL DMAWLAGQGY 

        70         80         90        100        110        120 
RVRGIELSRR AVEDFFQEQG LQAQVWQQGA FEVWCSGEVE LWCGDFFALR AEDVADCVGL 

       130        140        150        160        170        180 
YDRAALIALP PQMRERYMGL LSQILPVGSG LLVTLDYEQK LLAGPPFSVA DEEVRRGFAG 

       190        200        210 
WQVEEVEARD VIGESPKFLQ AGVKRLVERV YRVQF

« Hide

References

[1]"Complete sequence of Pseudomonas putida W619."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Taghavi S., Vangronsveld D., van der Lelie D., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: W619.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000949 Genomic DNA. Translation: ACA71984.1.
RefSeqYP_001748353.1. NC_010501.1.

3D structure databases

ProteinModelPortalB1J4W2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1J4W2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6110408.
GenomeReviewsGene locus PputW619_1479 in contig CP000949_GR.
KEGGppw:PputW619_1479.
PATRIC19952721. VBIPsePut93764_1483.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG444929.
OMAQGDIFTL.
ProtClustDBPRK13255.

Family and domain databases

HAMAPMF_00812. Thiopur_methtran.
[Tree]
InterProIPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR008854. Thiopurine_S-MeTrfase.
IPR016822. Thiopurine_S-MeTrfase_sub.
[Graphical view]
KOK00569.
PANTHERPTHR10259. PTHR10259. 1 hit.
PfamPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
TIGRFAMsTIGR03840. TMPT_Se_Te. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTPMT_PSEPW
AccessionPrimary (citable) accession number: B1J4W2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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