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Protein

Cytochrome c oxidase subunit 2

Gene

PputW619_0122

Organism
Pseudomonas putida (strain W619)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPPUT390235:GHHJ-122-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:PputW619_0122Imported
OrganismiPseudomonas putida (strain W619)Imported
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000720 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei87 – 105HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500276595723 – 375Cytochrome c oxidase subunit 2Sequence analysisAdd BLAST353

Interactioni

Protein-protein interaction databases

STRINGi390235.PputW619_0122.

Structurei

3D structure databases

ProteinModelPortaliB1J4K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 115COX2_TMInterPro annotationAdd BLAST96
Domaini116 – 253COX2_CUAInterPro annotationAdd BLAST138
Domaini273 – 353Cytochrome cInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
COG2010. LUCA.
HOGENOMiHOG000264987.
KOiK02275.
OMAiEHAYMPI.
OrthoDBiPOG091H05L4.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1J4K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRHPPVWMG LLLWLVLGQA NAAWTVNMAP GATEVSNAVF DLHMTIFWIC
60 70 80 90 100
VIIGVVVFGA MFWSMVIHRR STGQQAAHFH EHTWVEILWT VVPLLILVAM
110 120 130 140 150
AIPATKTLID IYDASESDID IQVTGYQWKW HYKYLGQDVE FFSNLATPAD
160 170 180 190 200
QIQNKAPKDE HYLLEVDQPL VLPVGAKVRF LVTAADVIHS WWVPAFAVKR
210 220 230 240 250
DAIPGFVNEA WTRVEKPGIY RGQCTELCGK DHGFMPVVVE VKSKADYDTW
260 270 280 290 300
LGERKAEAAK LKELTSKEWT LEELVARGDK VYHTTCVACH QAEGQGLPPM
310 320 330 340 350
FPALKGSKIA TGPKDAHLNI VFHGKPGTSM AAFGKQLSEV DIAAVVTYER
360 370
NAWGNDKGDM VTPKDVLALK QAQAQ
Length:375
Mass (Da):41,815
Last modified:April 29, 2008 - v1
Checksum:iF563D4657E09AD2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000949 Genomic DNA. Translation: ACA70628.1.
RefSeqiWP_012312074.1. NC_010501.1.

Genome annotation databases

EnsemblBacteriaiACA70628; ACA70628; PputW619_0122.
KEGGippw:PputW619_0122.
PATRICi19949965. VBIPsePut93764_0125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000949 Genomic DNA. Translation: ACA70628.1.
RefSeqiWP_012312074.1. NC_010501.1.

3D structure databases

ProteinModelPortaliB1J4K4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi390235.PputW619_0122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA70628; ACA70628; PputW619_0122.
KEGGippw:PputW619_0122.
PATRICi19949965. VBIPsePut93764_0125.

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
COG2010. LUCA.
HOGENOMiHOG000264987.
KOiK02275.
OMAiEHAYMPI.
OrthoDBiPOG091H05L4.

Enzyme and pathway databases

BioCyciPPUT390235:GHHJ-122-MONOMER.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1J4K4_PSEPW
AccessioniPrimary (citable) accession number: B1J4K4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.