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Protein

Cytochrome c oxidase subunit 2

Gene

PputW619_0122

Organism
Pseudomonas putida (strain W619)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemePROSITE-ProRule annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPPUT390235:G1GBA-124-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:PputW619_0122Imported
OrganismiPseudomonas putida (strain W619)Imported
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000720 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei87 – 105HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500276595723 – 375Cytochrome c oxidase subunit 2Sequence analysisAdd BLAST353

Interactioni

Protein-protein interaction databases

STRINGi390235.PputW619_0122

Structurei

3D structure databases

ProteinModelPortaliB1J4K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 115COX2_TMInterPro annotationAdd BLAST96
Domaini116 – 253COX2_CUAInterPro annotationAdd BLAST138
Domaini273 – 353Cytochrome cInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA
COG2010 LUCA
HOGENOMiHOG000264987
KOiK02275
OMAiHAFMPIA
OrthoDBiPOG091H05L4

Family and domain databases

Gene3Di1.10.287.90, 1 hit
1.10.760.10, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
PF13442 Cytochrome_CBB3, 1 hit
SUPFAMiSSF46626 SSF46626, 1 hit
SSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

B1J4K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRHPPVWMG LLLWLVLGQA NAAWTVNMAP GATEVSNAVF DLHMTIFWIC
60 70 80 90 100
VIIGVVVFGA MFWSMVIHRR STGQQAAHFH EHTWVEILWT VVPLLILVAM
110 120 130 140 150
AIPATKTLID IYDASESDID IQVTGYQWKW HYKYLGQDVE FFSNLATPAD
160 170 180 190 200
QIQNKAPKDE HYLLEVDQPL VLPVGAKVRF LVTAADVIHS WWVPAFAVKR
210 220 230 240 250
DAIPGFVNEA WTRVEKPGIY RGQCTELCGK DHGFMPVVVE VKSKADYDTW
260 270 280 290 300
LGERKAEAAK LKELTSKEWT LEELVARGDK VYHTTCVACH QAEGQGLPPM
310 320 330 340 350
FPALKGSKIA TGPKDAHLNI VFHGKPGTSM AAFGKQLSEV DIAAVVTYER
360 370
NAWGNDKGDM VTPKDVLALK QAQAQ
Length:375
Mass (Da):41,815
Last modified:April 29, 2008 - v1
Checksum:iF563D4657E09AD2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000949 Genomic DNA Translation: ACA70628.1
RefSeqiWP_012312074.1, NC_010501.1

Genome annotation databases

EnsemblBacteriaiACA70628; ACA70628; PputW619_0122
KEGGippw:PputW619_0122

Similar proteinsi

Entry informationi

Entry nameiB1J4K4_PSEPW
AccessioniPrimary (citable) accession number: B1J4K4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health