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B1IXX9

- GAL1_ECOLC

UniProt

B1IXX9 - GAL1_ECOLC

Protein

Galactokinase

Gene

galK

Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).UniRule annotation

    Catalytic activityi

    ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei28 – 281Transition state stabilizerUniRule annotation
    Metal bindingi130 – 1301MagnesiumUniRule annotation
    Metal bindingi162 – 1621MagnesiumUniRule annotation
    Active sitei174 – 1741Proton acceptorUniRule annotation
    Binding sitei223 – 2231SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi124 – 1307ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. galactokinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. galactose metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Galactose metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL481805:GI3G-2961-MONOMER.
    UniPathwayiUPA00214.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GalactokinaseUniRule annotation (EC:2.7.1.6UniRule annotation)
    Alternative name(s):
    Galactose kinaseUniRule annotation
    Gene namesi
    Name:galKUniRule annotation
    Ordered Locus Names:EcolC_2905
    OrganismiEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
    Taxonomic identifieri481805 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000317: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382GalactokinasePRO_1000078407Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi481805.EcolC_2905.

    Structurei

    3D structure databases

    ProteinModelPortaliB1IXX9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni34 – 374Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the GHMP kinase family. GalK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0153.
    HOGENOMiHOG000241100.
    KOiK00849.
    OMAiVMPCAIN.
    OrthoDBiEOG6DG2SH.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00246. Galactokinase.
    InterProiIPR000705. Galactokinase.
    IPR022963. Galactokinase_bac.
    IPR019741. Galactokinase_CS.
    IPR019539. GalKase_gal-bd.
    IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006206. Mevalonate/galactokinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PfamiPF10509. GalKase_gal_bdg. 1 hit.
    PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000530. Galactokinase. 1 hit.
    PRINTSiPR00473. GALCTOKINASE.
    PR00959. MEVGALKINASE.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00131. gal_kin. 1 hit.
    PROSITEiPS00106. GALACTOKINASE. 1 hit.
    PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1IXX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLKEKTQSL FANAFGYPAT HTIQAPGRVN LIGEHTDYND GFVLPCAIDY    50
    QTVISCAPRD DRKVRVMAAD YENQLDEFSL DAPIVAHENY QWANYVRGVV 100
    KHLQLRNNSF GGVDMVISGN VPQGAGLSSS ASLEVAVGTV LQQLYHLPLD 150
    GAQIALNGQE AENQFVGCNC GIMDQLISAL GKKDHALLID CRSLGTKAVS 200
    MPKGVAVVII NSNFKRTLVG SEYNTRREQC ETGARFFQQP ALRDVTIEEF 250
    NAVAHELDPI VAKRVRHILT ENARTVEAAS ALEQGDLKRM GELMAESHAS 300
    MRDDFEITVP QIDTLVEIVK AVIGDKGGVR MTGGGFGGCI VALIPEELVP 350
    AVQQAVAEQY EAKTGIKETF YVCKPSQGAG QC 382
    Length:382
    Mass (Da):41,442
    Last modified:April 29, 2008 - v1
    Checksum:i7D886CE6FC48F0A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000946 Genomic DNA. Translation: ACA78532.1.
    RefSeqiYP_001725859.1. NC_010468.1.

    Genome annotation databases

    EnsemblBacteriaiACA78532; ACA78532; EcolC_2905.
    GeneIDi6065384.
    KEGGiecl:EcolC_2905.
    PATRICi18228764. VBIEscCol82905_3100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000946 Genomic DNA. Translation: ACA78532.1 .
    RefSeqi YP_001725859.1. NC_010468.1.

    3D structure databases

    ProteinModelPortali B1IXX9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 481805.EcolC_2905.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA78532 ; ACA78532 ; EcolC_2905 .
    GeneIDi 6065384.
    KEGGi ecl:EcolC_2905.
    PATRICi 18228764. VBIEscCol82905_3100.

    Phylogenomic databases

    eggNOGi COG0153.
    HOGENOMi HOG000241100.
    KOi K00849.
    OMAi VMPCAIN.
    OrthoDBi EOG6DG2SH.

    Enzyme and pathway databases

    UniPathwayi UPA00214 .
    BioCyci ECOL481805:GI3G-2961-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00246. Galactokinase.
    InterProi IPR000705. Galactokinase.
    IPR022963. Galactokinase_bac.
    IPR019741. Galactokinase_CS.
    IPR019539. GalKase_gal-bd.
    IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006206. Mevalonate/galactokinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    Pfami PF10509. GalKase_gal_bdg. 1 hit.
    PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000530. Galactokinase. 1 hit.
    PRINTSi PR00473. GALCTOKINASE.
    PR00959. MEVGALKINASE.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00131. gal_kin. 1 hit.
    PROSITEi PS00106. GALACTOKINASE. 1 hit.
    PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Escherichia coli C str. ATCC 8739."
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Ingram L., Richardson P.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8739 / DSM 1576 / Crooks.

    Entry informationi

    Entry nameiGAL1_ECOLC
    AccessioniPrimary (citable) accession number: B1IXX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3