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B1IXD2

- RIMO_ECOLC

UniProt

B1IXD2 - RIMO_ECOLC

Protein

Ribosomal protein S12 methylthiotransferase RimO

Gene

rimO

Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi53 – 531Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi82 – 821Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi150 – 1501Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi154 – 1541Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi157 – 1571Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP
    3. transferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid Source: UniProtKB-HAMAP
    2. RNA modification Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciECOL481805:GI3G-2863-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal protein S12 methylthiotransferase RimOUniRule annotation (EC:2.-.-.-UniRule annotation)
    Short name:
    S12 MTTaseUniRule annotation
    Short name:
    S12 methylthiotransferaseUniRule annotation
    Alternative name(s):
    Ribosome maturation factor RimOUniRule annotation
    Gene namesi
    Name:rimOUniRule annotation
    Ordered Locus Names:EcolC_2807
    OrganismiEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
    Taxonomic identifieri481805 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000317: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Ribosomal protein S12 methylthiotransferase RimOPRO_0000374817Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi481805.EcolC_2807.

    Structurei

    3D structure databases

    ProteinModelPortaliB1IXD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 118111MTTase N-terminalUniRule annotationAdd
    BLAST
    Domaini376 – 44166TRAMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methylthiotransferase family. RimO subfamily.UniRule annotation
    Contains 1 MTTase N-terminal domain.UniRule annotation
    Contains 1 TRAM domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0621.
    HOGENOMiHOG000224766.
    KOiK14441.
    OMAiERYHRFM.
    OrthoDBiEOG6P5ZD8.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.80.30.20. 1 hit.
    HAMAPiMF_01865. MTTase_RimO.
    InterProiIPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR012340. NA-bd_OB-fold.
    IPR005840. Ribosomal_S12_MeSTrfase_RimO.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view]
    PANTHERiPTHR11918. PTHR11918. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
    TIGR01125. TIGR01125. 1 hit.
    PROSITEiPS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1IXD2-1 [UniParc]FASTAAdd to Basket

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    MSKVTPQPKI GFVSLGCPKN LVDSERILTE LRTEGYDVVP SYDDADMVIV    50
    NTCGFIDSAV QESLEAIGEA LNENGKVIVT GCLGAKEDQI REVHPKVLEI 100
    TGPHSYEQVL EHVHHYVPKP KHNPFLSLVP EQGVKLTPRH YAYLKISEGC 150
    NHRCTFCIIP SMRGDLVSRP IGEVLSEAKR LVDAGVKEIL VISQDTSAYG 200
    VDVKHRTGFH NGEPVKTSMV SLCEQLSKLG IWTRLHYVYP YPHVDDVIPL 250
    MAEGKILPYL DIPLQHASPR ILKLMKRPGS VDRQLARIKQ WREICPELTL 300
    RSTFIVGFPG ETEEDFQMLL DFLKEARLDR VGCFKYSPVE GADANALPDQ 350
    VPEEVKEERW NRFMQLQQQI SAERLQEKVG REILVIIDEV DEEGAIGRSM 400
    ADAPEIDGAV YLNGETNVKP GDILRVKVEH ADEYDLWGSR V 441
    Length:441
    Mass (Da):49,582
    Last modified:April 29, 2008 - v1
    Checksum:iE1D4605388AFB889
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000946 Genomic DNA. Translation: ACA78435.1.
    RefSeqiYP_001725762.1. NC_010468.1.

    Genome annotation databases

    EnsemblBacteriaiACA78435; ACA78435; EcolC_2807.
    GeneIDi6065001.
    KEGGiecl:EcolC_2807.
    PATRICi18228570. VBIEscCol82905_3003.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000946 Genomic DNA. Translation: ACA78435.1 .
    RefSeqi YP_001725762.1. NC_010468.1.

    3D structure databases

    ProteinModelPortali B1IXD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 481805.EcolC_2807.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA78435 ; ACA78435 ; EcolC_2807 .
    GeneIDi 6065001.
    KEGGi ecl:EcolC_2807.
    PATRICi 18228570. VBIEscCol82905_3003.

    Phylogenomic databases

    eggNOGi COG0621.
    HOGENOMi HOG000224766.
    KOi K14441.
    OMAi ERYHRFM.
    OrthoDBi EOG6P5ZD8.

    Enzyme and pathway databases

    BioCyci ECOL481805:GI3G-2863-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.80.30.20. 1 hit.
    HAMAPi MF_01865. MTTase_RimO.
    InterProi IPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR012340. NA-bd_OB-fold.
    IPR005840. Ribosomal_S12_MeSTrfase_RimO.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view ]
    PANTHERi PTHR11918. PTHR11918. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
    TIGR01125. TIGR01125. 1 hit.
    PROSITEi PS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Escherichia coli C str. ATCC 8739."
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Ingram L., Richardson P.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8739 / DSM 1576 / Crooks.

    Entry informationi

    Entry nameiRIMO_ECOLC
    AccessioniPrimary (citable) accession number: B1IXD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3