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B1IVG1 (CDH_ECOLC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CDP-diacylglycerol pyrophosphatase
EC=3.6.1.26
Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase
Gene names
Name:cdh
Ordered Locus Names:EcolC_4100
OrganismEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) [Complete proteome] [HAMAP]
Taxonomic identifier481805 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319

Pathway

Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319

Subcellular location

Cell inner membrane; Single-pass membrane protein By similarity HAMAP MF_00319.

Sequence similarities

Belongs to the cdh family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionCDP-diacylglycerol diphosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251CDP-diacylglycerol pyrophosphatase HAMAP MF_00319
PRO_1000079160

Regions

Transmembrane4 – 2421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B1IVG1 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: C983D7A4B52FE5F3

FASTA25128,365
        10         20         30         40         50         60 
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP 

        70         80         90        100        110        120 
NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP 

       130        140        150        160        170        180 
DRAVSLAINS RTGRTQNHFH IHISCIRPDV REQLDNNLAN ISSRWLPLPG GLRGHEYLAR 

       190        200        210        220        230        240 
RVTESELVQR SPFIMLAEEV PEAREHMGSY GLAMVRQSDN SFVLLATQRN LLTLNRASAE 

       250 
EIQDHQCEIL R

« Hide

References

[1]"Complete sequence of Escherichia coli C str. ATCC 8739."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Ingram L., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8739 / DSM 1576 / Crooks.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000946 Genomic DNA. Translation: ACA79698.1.
RefSeqYP_001727025.1. NC_010468.1.

3D structure databases

ProteinModelPortalB1IVG1.
SMRB1IVG1. Positions 31-250.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1IVG1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000008858; EBESCP00000008542; EBESCG00000007921.
GeneID6065760.
GenomeReviewsGene locus EcolC_4100 in contig CP000946_GR.
KEGGecl:EcolC_4100.
PATRIC18231437. VBIEscCol82905_4392.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000011118.
HOGENOMHBG565233.
OMADINGPLQ.
ProtClustDBPRK05471.

Enzyme and pathway databases

BioCycECOL481805:ECOLC_4100-MONOMER.

Family and domain databases

HAMAPMF_00319. Cdh.
[Tree]
InterProIPR003763. CDP-diacylglyc_Pase.
IPR015993. CDP-diacylglyc_Pase_proteobac.
[Graphical view]
KOK01521.
PfamPF02611. CDH. 1 hit.
[Graphical view]
PIRSFPIRSF001273. CDH. 1 hit.
TIGRFAMsTIGR00672. Cdh. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDH_ECOLC
AccessionPrimary (citable) accession number: B1IVG1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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