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B1IUL3 (UBIC_ECOLC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40
Gene names
Name:ubiC
Ordered Locus Names:EcolC_3989
OrganismEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) [Complete proteome] [HAMAP]
Taxonomic identifier481805 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632

Catalytic activity

Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632

Subunit structure

Monomer By similarity. HAMAP MF_01632

Subcellular location

Cytoplasm By similarity HAMAP MF_01632.

Sequence similarities

Belongs to the ubiC family.

Ontologies

Keywords
   Biological processUbiquinone biosynthesis
   Cellular componentCytoplasm
   LigandPyruvate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processubiquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionchorismate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Chorismate--pyruvate lyase HAMAP MF_01632
PRO_1000088145

Sites

Binding site351Substrate; via amide nitrogen By similarity
Binding site771Substrate By similarity
Binding site1151Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B1IUL3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: ED8A9825B963D9EF

FASTA16518,821
        10         20         30         40         50         60 
MSHPALTQLR ALRYFKEIPA LDPQLLDWLL LEDSMTKRFE QQGKTVSVTM IREGFVEQNE 

        70         80         90        100        110        120 
IPEELPLLPK ESRYWLREIL LCADGEPWLA GRTVVPVSTL SGPELALQKL GKTPLGRYLF 

       130        140        150        160 
TSSTLTRDFI EIGRDAGLWG RRSRLRLSGK PLLLTELFLP ASPLY

« Hide

References

[1]"Complete sequence of Escherichia coli C str. ATCC 8739."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Ingram L., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8739 / DSM 1576 / Crooks.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000946 Genomic DNA. Translation: ACA79590.1.
RefSeqYP_001726917.1. NC_010468.1.

3D structure databases

ProteinModelPortalB1IUL3.
SMRB1IUL3. Positions 2-165.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1IUL3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000008396; EBESCP00000008080; EBESCG00000007459.
GeneID6064533.
GenomeReviewsGene locus EcolC_3989 in contig CP000946_GR.
KEGGecl:EcolC_3989.
PATRIC18231173. VBIEscCol82905_4272.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000011008.
HOGENOMHBG644467.
OMAGRTVIPQ.
ProtClustDBPRK11655.

Enzyme and pathway databases

BioCycECOL481805:ECOLC_3989-MONOMER.

Family and domain databases

HAMAPMF_01632. UbiC.
[Tree]
InterProIPR007440. Chorismate--pyruvate_lyase.
[Graphical view]
KOK03181.
PfamPF04345. Chor_lyase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBIC_ECOLC
AccessionPrimary (citable) accession number: B1IUL3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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