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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciECOL481805:GI3G-3827-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:EcolC_3742
OrganismiEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Taxonomic identifieri481805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Mannonate dehydratasePRO_1000075899Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi481805.EcolC_3742.

Structurei

3D structure databases

ProteinModelPortaliB1ISA3.
SMRiB1ISA3. Positions 1-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiEOG6ZSP6Z.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 2 hits.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

B1ISA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTWRWYGP NDPVSLADVR QAGATGVVTA LHHIPNGEVW SVEEILKRKA
60 70 80 90 100
IVEDAGLVWS VVESVPIHED IKTHTGNYEQ WIANYQQTLR NLAQCGIRTV
110 120 130 140 150
CYNFMPVLDW TRTDLEYVLP DGSKALRFDQ IEFAAFEMHI LKRPGAEADY
160 170 180 190 200
TEEEIAQAAV RFATMSDEDK ARLTRNIIAG LPGAEEGYTL DQFRKHLELY
210 220 230 240 250
KDIDKAKLRE NFAVFLKAII PVAEEVGVRM AVHPDDPPRP ILGLPRIVST
260 270 280 290 300
IEDMQWMVDT VNSMANGFTM CTGSYGVRAD NDLVDMIKQF GPRIYFTHLR
310 320 330 340 350
STMREDNPKT FHEAAHLNGD VDMYEVVKAI VEEEHRRKAE GKEDLIPMRP
360 370 380
DHGHQMLDDL KKKTNPGYSA IGRLKGLAEV RGTGTGSGA
Length:389
Mass (Da):43,907
Last modified:April 29, 2008 - v1
Checksum:i9DED908842F1C382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000946 Genomic DNA. Translation: ACA79351.1.
RefSeqiWP_000438590.1. NC_010468.1.

Genome annotation databases

EnsemblBacteriaiACA79351; ACA79351; EcolC_3742.
KEGGiecl:EcolC_3742.
PATRICi18230624. VBIEscCol82905_4003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000946 Genomic DNA. Translation: ACA79351.1.
RefSeqiWP_000438590.1. NC_010468.1.

3D structure databases

ProteinModelPortaliB1ISA3.
SMRiB1ISA3. Positions 1-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi481805.EcolC_3742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA79351; ACA79351; EcolC_3742.
KEGGiecl:EcolC_3742.
PATRICi18230624. VBIEscCol82905_4003.

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiEOG6ZSP6Z.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciECOL481805:GI3G-3827-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 2 hits.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Escherichia coli C str. ATCC 8739."
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Ingram L., Richardson P.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8739 / DSM 1576 / Crooks.

Entry informationi

Entry nameiUXUA_ECOLC
AccessioniPrimary (citable) accession number: B1ISA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 29, 2008
Last modified: November 11, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.