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Protein

Autoinducer-2 kinase

Gene

lsrK

Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.UniRule annotation

Catalytic activityi

ATP + (S)-4,5-dihydroxypentane-2,3-dione = ADP + (S)-4-hydroxy-2,3-pentanedione 5-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Enzyme and pathway databases

BioCyciECOL481805:GI3G-2193-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Autoinducer-2 kinaseUniRule annotation (EC:2.7.1.189UniRule annotation)
Short name:
AI-2 kinaseUniRule annotation
Gene namesi
Name:lsrKUniRule annotation
Ordered Locus Names:EcolC_2147
OrganismiEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Taxonomic identifieri481805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Autoinducer-2 kinasePRO_0000351587Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi481805.EcolC_2147.

Structurei

3D structure databases

ProteinModelPortaliB1IRU9.
SMRiB1IRU9. Positions 13-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108EMV. Bacteria.
COG1070. LUCA.
HOGENOMiHOG000092677.
KOiK11216.
OMAiFSDAMHF.
OrthoDBiEOG6QRW4M.

Family and domain databases

HAMAPiMF_02053. LsrK.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.

Sequencei

Sequence statusi: Complete.

B1IRU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLFTPSES KYYLMALDAG TGSIRAVIFD LEGNQIAVGQ AEWRHLAVPD
60 70 80 90 100
VPGSMEFDLN KNWQLACECM RQALHNAGIA PEYIAAVSAC SMREGIVLYN
110 120 130 140 150
NEGTPIWACA NVDARAAREV SELKELHNNT FENEVYRATG QTLALSAIPR
160 170 180 190 200
LLWLAHHRSD IYRQASTITM ISDWLAYMLS GELAVDPSNA GTTGLLDLTT
210 220 230 240 250
RNWKPALLDM AGLRADILSP VKETGTLLGV VSSQAAELCG LKAGTPVVVG
260 270 280 290 300
GGDVQLGCLG LGVVRPAQTA VLGGTFWQQV VNLAAPVTDP EMNVRVNPHV
310 320 330 340 350
IPGMVQAESI SFFTGLTMRW FRDAFCAEEK LIAERLGIDT YTLLEEMASR
360 370 380 390 400
VPPGSWGVMP IFSDRMRFKT WYHAAPSFIN LSIDPDKCNK ATLFRALEEN
410 420 430 440 450
AAIVSACNLQ QIADFSNIHP TSLVFAGGGS KGKLWSQILA DVSGLPVNIP
460 470 480 490 500
VVKEATALGC AIAAGVGAGI FSSMAETGER LVRWERTHTP DPEKHELYQD
510 520 530
SRDKWQAVYQ DQLGLVDHGL TTSLWKAPGL
Length:530
Mass (Da):57,572
Last modified:April 29, 2008 - v1
Checksum:i7FBB7DFE6957B405
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000946 Genomic DNA. Translation: ACA77787.1.
RefSeqiWP_000113150.1. NC_010468.1.

Genome annotation databases

EnsemblBacteriaiACA77787; ACA77787; EcolC_2147.
KEGGiecl:EcolC_2147.
PATRICi18227152. VBIEscCol82905_2299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000946 Genomic DNA. Translation: ACA77787.1.
RefSeqiWP_000113150.1. NC_010468.1.

3D structure databases

ProteinModelPortaliB1IRU9.
SMRiB1IRU9. Positions 13-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi481805.EcolC_2147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA77787; ACA77787; EcolC_2147.
KEGGiecl:EcolC_2147.
PATRICi18227152. VBIEscCol82905_2299.

Phylogenomic databases

eggNOGiENOG4108EMV. Bacteria.
COG1070. LUCA.
HOGENOMiHOG000092677.
KOiK11216.
OMAiFSDAMHF.
OrthoDBiEOG6QRW4M.

Enzyme and pathway databases

BioCyciECOL481805:GI3G-2193-MONOMER.

Family and domain databases

HAMAPiMF_02053. LsrK.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Escherichia coli C str. ATCC 8739."
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Ingram L., Richardson P.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8739 / DSM 1576 / Crooks.

Entry informationi

Entry nameiLSRK_ECOLC
AccessioniPrimary (citable) accession number: B1IRU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: April 29, 2008
Last modified: February 17, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.