Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carnitinyl-CoA dehydratase

Gene

caiD

Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.UniRule annotation

Catalytic activityi

L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei111Important for catalytic activityUniRule annotation1
Sitei131Important for catalytic activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

UniPathwayiUPA00117

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitinyl-CoA dehydrataseUniRule annotation (EC:4.2.1.149UniRule annotation)
Alternative name(s):
Crotonobetainyl-CoA hydrataseUniRule annotation
Gene namesi
Name:caiDUniRule annotation
Ordered Locus Names:EcolC_3619
OrganismiEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Taxonomic identifieri481805 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000844251 – 261Carnitinyl-CoA dehydrataseAdd BLAST261

Proteomic databases

PRIDEiB1IRE0

Structurei

3D structure databases

ProteinModelPortaliB1IRE0
SMRiB1IRE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106YT9 Bacteria
COG1024 LUCA
HOGENOMiHOG000027939
KOiK08299
OMAiKGRAMEM

Family and domain databases

Gene3Di1.10.12.10, 1 hit
HAMAPiMF_01051 CaiD, 1 hit
InterProiView protein in InterPro
IPR022852 Carnitinyl_CoA_dehydratase
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 enoyl-CoA_hydra_C
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

B1IRE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESLHLTRN GSILEITLDR PKANAIDAKT SFEMGEVFLN FRDDPQLRVA
60 70 80 90 100
IITGAGEKFF SAGWDLKAAA EGEAPDADFG PGGFAGLTEI FNLDKPVIAA
110 120 130 140 150
VNGYAFGGGF ELALAADFIV CADNASFALP EAKLGIVPDS GGVLRLPKIL
160 170 180 190 200
PPAIVNEMVM TGRRMGAEEA LRWGIVNRVV SQAELMDNAR ELAQQLVNSA
210 220 230 240 250
PLAIAALKEI YRTTSEMPVE EAYRYIRSGV LKHYPSVLHS EDAIEGPLAF
260
AEKRDPVWKG R
Length:261
Mass (Da):28,190
Last modified:April 29, 2008 - v1
Checksum:i2C4DD6C3D16995CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000946 Genomic DNA Translation: ACA79233.1
RefSeqiWP_001295419.1, NC_010468.1

Genome annotation databases

EnsemblBacteriaiACA79233; ACA79233; EcolC_3619
KEGGiecl:EcolC_3619

Similar proteinsi

Entry informationi

Entry nameiCAID_ECOLC
AccessioniPrimary (citable) accession number: B1IRE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health