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B1IRD7 (CAIA_ECOLC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Crotonobetainyl-CoA dehydrogenase
EC=1.3.99.-
Alternative name(s):
Crotonobetainyl-CoA reductase
Gene names
Name:caiA
Ordered Locus Names:EcolC_3616
OrganismEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) [Complete proteome] [HAMAP]
Taxonomic identifier481805 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA By similarity. HAMAP MF_01052

Cofactor

FAD By similarity. HAMAP MF_01052

Pathway

Amine and polyamine metabolism; carnitine metabolism. HAMAP MF_01052

Subunit structure

Homotetramer By similarity. HAMAP MF_01052

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionacyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Crotonobetainyl-CoA dehydrogenase HAMAP MF_01052
PRO_1000084428

Sequences

Sequence LengthMass (Da)Tools
B1IRD7 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 7076984D735652C3

FASTA38042,558
        10         20         30         40         50         60 
MDFNLNDEQE LFVAGIRELM ASENWEAYFA ECDRDSVYPE RFVKALADMG IDSLLIPEEH 

        70         80         90        100        110        120 
GGLDAGFVTL AAVWMELGRL GAPTYVLYQL PGGFNTFLRE GTQEQIDKIM AFRGTGKQMW 

       130        140        150        160        170        180 
NSAITEPGAG SDVGSLKTTY TRRNGKIYLN GSKCFITSSA YTPYIVVMAR DGASPDKPVY 

       190        200        210        220        230        240 
TEWFVDMSKP GIKVTKLEKL GLRMDSCCEI TFDDVELDEK DMFGREGNGF NRVKEEFDHE 

       250        260        270        280        290        300 
RFLVALTNYG TAMCAFEDAA RYANQRVQFG EAIGRFQLIQ EKFAHMAIKL NSMKNMLYEA 

       310        320        330        340        350        360 
AWKADNGTIT SGDAAMCKYF CANAAFEVVD SAMQVLGGVG IAGNHRISRF WRDLRVDRVS 

       370        380 
GGSDEMQILT LGRAVLKQYR

« Hide

References

[1]"Complete sequence of Escherichia coli C str. ATCC 8739."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Ingram L., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8739 / DSM 1576 / Crooks.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000946 Genomic DNA. Translation: ACA79230.1.
RefSeqYP_001726557.1. NC_010468.1.

3D structure databases

ProteinModelPortalB1IRD7.
SMRB1IRD7. Positions 5-377.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1IRD7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000009534; EBESCP00000009218; EBESCG00000008597.
GeneID6066209.
GenomeReviewsGene locus EcolC_3616 in contig CP000946_GR.
KEGGecl:EcolC_3616.
PATRIC18230338. VBIEscCol82905_3863.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008857.
HOGENOMHBG699365.
OMAETIGRFQ.
ProtClustDBPRK03354.

Enzyme and pathway databases

BioCycECOL481805:ECOLC_3616-MONOMER.

Family and domain databases

HAMAPMF_01052. CaiA.
[Tree]
InterProIPR006089. Acyl-CoA_DH_CS.
IPR006092. Acyl-CoA_DH_N.
IPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase.
IPR023450. Crotonobetainyl-CoA_DHase_CaiA.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
KOK08297.
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMSSF56645. AcylCoA_dehyd_NM. 1 hit.
SSF47203. AcylCoADH_C_like. 1 hit.
PROSITEPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAIA_ECOLC
AccessionPrimary (citable) accession number: B1IRD7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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