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B1IQ91 (MDTK_ECOLC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene names
Name:mdtK
Ordered Locus Names:EcolC_1966
OrganismEscherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) [Complete proteome] [HAMAP]
Taxonomic identifier481805 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity. HAMAP-Rule MF_00400

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00400.

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]

Ontologies

Keywords
   Biological processAntiport
Ion transport
Sodium transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionantiporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

drug transmembrane transporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Multidrug resistance protein MdtK HAMAP-Rule MF_00400
PRO_1000080330

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane276 – 29621Helical; Potential
Transmembrane314 – 33421Helical; Potential
Transmembrane350 – 37021Helical; Potential
Transmembrane387 – 40721Helical; Potential
Transmembrane418 – 43821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B1IQ91 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 43777F14A029EAC6

FASTA45749,479
        10         20         30         40         50         60 
MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG TSIWLPAILF 

        70         80         90        100        110        120 
GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV LIMLVLWNAG YIIRSMENID 

       130        140        150        160        170        180 
PALAEKAVGY LRALLWGAPG YLFFQVARNQ CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY 

       190        200        210        220        230        240 
GHFGMPELGG VGCGVATAAV YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ 

       250        260        270        280        290        300 
LGLPIALALF FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG 

       310        320        330        340        350        360 
YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV VTLAAHLMLL 

       370        380        390        400        410        420 
AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL PSGYILALTD LVVEPMGPAG 

       430        440        450 
FWIGFIIGLT SAAIMMMLRM RFLQRMPSAI ILQRASR 

« Hide

References

[1]"Complete sequence of Escherichia coli C str. ATCC 8739."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Ingram L., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8739 / DSM 1576 / Crooks.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000946 Genomic DNA. Translation: ACA77612.1.
RefSeqYP_001724939.1. NC_010468.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING481805.EcolC_1966.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA77612; ACA77612; EcolC_1966.
GeneID6068252.
KEGGecl:EcolC_1966.
PATRIC18226782. VBIEscCol82905_2114.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0534.
HOGENOMHOG000038538.
KOK03327.
OMAGGVGCGW.
OrthoDBEOG6423C5.

Enzyme and pathway databases

BioCycECOL481805:GI3G-2011-MONOMER.

Family and domain databases

HAMAPMF_00400. MdtK.
InterProIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDTK_ECOLC
AccessionPrimary (citable) accession number: B1IQ91
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families