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B1INE4 (PYRF_CLOBK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:CLD_1293
OrganismClostridium botulinum (strain Okra / Type B1) [Complete proteome] [HAMAP]
Taxonomic identifier498213 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_1000164746

Sites

Active site971Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
B1INE4 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: C101A05733ED5C69

FASTA28331,858
        10         20         30         40         50         60 
MIIDKLYENV EKKGCVCVGL DTDISYLPKG FLNKFTNIED AIFAFNQRIV DSTFDVSACY 

        70         80         90        100        110        120 
KVQIAYYEAM GIKGMILYKK TLEYIRKKGG IVIADIKRGD ISATAKMYAK AHFEGDFESD 

       130        140        150        160        170        180 
FITLNPYMGM DTLEPYKDYF KNKEKGVFLL LRTSNEGSKD IQYLDLKDNK KVYNKVGEKI 

       190        200        210        220        230        240 
ENIGKEFLGN CGYSSIGAVV GCTAEENNIR KELKHTFFLI PGYGAQGGKA EVAKSYLSEG 

       250        260        270        280 
NGGIVNSSRG ILLAYKKYDE EGKNFEECAR NEVINMKKTL QII 

« Hide

References

[1]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Okra / Type B1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000939 Genomic DNA. Translation: ACA46510.1.
RefSeqYP_001782877.1. NC_010516.1.

3D structure databases

ProteinModelPortalB1INE4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING498213.CLD_1293.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA46510; ACA46510; CLD_1293.
GeneID6150592.
KEGGcbb:CLD_1293.
PATRIC19406928. VBICloBot127283_3360.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OMAHIHARHP.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycCBOT498213:GCNI-3314-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_CLOBK
AccessionPrimary (citable) accession number: B1INE4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways