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B1IL57

- PUR9_CLOBK

UniProt

B1IL57 - PUR9_CLOBK

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Clostridium botulinum (strain Okra / Type B1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCBOT498213:GCNI-2939-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:CLD_1667
OrganismiClostridium botulinum (strain Okra / Type B1)
Taxonomic identifieri498213 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008541: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Bifunctional purine biosynthesis protein PurHPRO_1000096055Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi498213.CLD_1667.

Structurei

3D structure databases

ProteinModelPortaliB1IL57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B1IL57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKRALISVF DKTGILDLAK FLESRDVEII STGGTYKHLK ENGVKVIDIE
60 70 80 90 100
EVTGFPEMLD GRVKTLNPLI HGGILAIRDN EEHMKVIEEK GINPIDMVVV
110 120 130 140 150
NLYPFFNKVE ENLSFDEKVE FIDIGGPTMI RAAAKNFKDV VVLTDTKDYE
160 170 180 190 200
NVIDEIKEND QVNIKTRKKL AGKVFNLMSA YDAAISNFLL EEEYPEYLTL
210 220 230 240 250
SYKKNMDLRY GENPHQTAAY YTSTVGKYPM KNFEKLNGKE LSYNNIKDMD
260 270 280 290 300
IAWKTVCEFE EVACCALKHN TPCGVAIGDT VQEVYTKAYE CDPISIFGGI
310 320 330 340 350
VAFNRKVDKE TAENLAKIFL EIVVAPDFDE DALEVLKNKK NLRVIKCEEK
360 370 380 390 400
STEGKDMAKV DGGILVQKSD NKLLEDTKVV TEKSPTEQEM KDLIFGMKVV
410 420 430 440 450
KYVKSNAIVV VKDGMAKGIG GGQVNRIWAA KEALDRAGDG IVLASDAFFP
460 470 480 490
FGDVAEEAAK WGIKAIIQPG GSIRDEESIK VCDEKGISMV FTGIRHFKH
Length:499
Mass (Da):55,792
Last modified:April 29, 2008 - v1
Checksum:i20627D76EC582D61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000939 Genomic DNA. Translation: ACA43511.1.
RefSeqiWP_003403046.1. NC_010516.1.
YP_001782512.1. NC_010516.1.

Genome annotation databases

EnsemblBacteriaiACA43511; ACA43511; CLD_1667.
GeneIDi6148898.
KEGGicbb:CLD_1667.
PATRICi19406176. VBICloBot127283_2992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000939 Genomic DNA. Translation: ACA43511.1 .
RefSeqi WP_003403046.1. NC_010516.1.
YP_001782512.1. NC_010516.1.

3D structure databases

ProteinModelPortali B1IL57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498213.CLD_1667.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA43511 ; ACA43511 ; CLD_1667 .
GeneIDi 6148898.
KEGGi cbb:CLD_1667.
PATRICi 19406176. VBICloBot127283_2992.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CBOT498213:GCNI-2939-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Okra / Type B1.

Entry informationi

Entry nameiPUR9_CLOBK
AccessioniPrimary (citable) accession number: B1IL57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3