B1IJE1 (B1IJE1_CLOBK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thioredoxin reductase RuleBase RU003881
EC=1.8.1.9 RuleBase RU003881

Gene names

Name:	trxB EMBL ACA45046.1
Ordered Locus Names:	CLD_3308

Organism

Clostridium botulinum (strain Okra / Type B1) [Complete proteome] [HAMAP]

Taxonomic identifier

498213 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH. RuleBase RU003881
Cofactor	Binds 1 FAD per subunit By similarity. RuleBase RU003881
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. RuleBase RU003880

Ontologies

Keywords
Domain	Redox-active center RuleBase RU003880
Ligand	FAD RuleBase RU003880 Flavoprotein RuleBase RU003880
Molecular function	Oxidoreductase RuleBase RU003880 EMBL ACA45046.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1IJE1 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 7C5287DD0CEE489D	FASTA	313	34,238
	10 20 30 40 50 60 MENLYDVIII GSGPAGLSAG LYAARARLKT LILERNKAGG QIVITDEVAN YPGSIRDATG 70 80 90 100 110 120 ASLVARMEEQ VDEFGAERKK DNVKEVDFTG KIKIIKGEKE EYKAKSVIIA TGAAPRHIGC 130 140 150 160 170 180 KGENELIGKG VSYCATCDAD FFTDLEVFVI GGGDSALEEA LYLTKFARKV TVVHRRDALR 190 200 210 220 230 240 GAKSIQEKVF KNPKIEIMWD SVVEEIKGDG IVESAVFKNK KTGEITEYFA DEDDGTFGIF 250 260 270 280 290 300 VFVGYLPINN LFKDIVIMNE AGYIKTNDRM ETNIEGIFAA GDIREKSLRQ VVTAAADGAI 310 AAVEAYKYVE DTF

References

[1]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000939 Genomic DNA. Translation: ACA45046.1.
RefSeq	YP_001780883.1. NC_010516.1.
3D structure databases
ProteinModelPortal	B1IJE1.
ModBase	Search...
Protein-protein interaction databases
STRING	B1IJE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6149722.
GenomeReviews	Gene locus CLD_3308 in contig CP000939_GR.
KEGG	cbb:CLD_3308.
PATRIC	19402992. VBICloBot127283_1400.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG669726.
OMA	GEEREFP.
ProtClustDB	CLSK966045.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1IJE1_CLOBK

Accession

Primary (citable) accession number: B1IJE1

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)