B1IC10 (URK_STRPI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine kinase
EC=2.7.1.48

Alternative name(s):
Cytidine monophosphokinase
Uridine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	SPH_1326

Organism

Streptococcus pneumoniae (strain Hungary19A-6) [Complete proteome] [HAMAP]

Taxonomic identifier

487214 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP-Rule MF_00551 ATP + cytidine = ADP + CMP. HAMAP-Rule MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP-Rule MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP-Rule MF_00551
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	CTP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway UMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Uridine kinase HAMAP-Rule MF_00551		PRO_1000129092
Regions
	Nucleotide binding	12 – 19	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B1IC10 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 47B405D377C70A8A	FASTA	212	24,466
	10 20 30 40 50 60 MQNRPIIIGV TGGSGGGKTS VSRAILSHFP DEKISMIEHD SYYKDQSHLT FEERVKTNYD 70 80 90 100 110 120 HPFAFDTDLM IEQIKELLAG RPVDIPTYDY TEHTRSSKTY RQEPQDVFIV EGILVLEDKR 130 140 150 160 170 180 LRDLMDIKIF VDTDDDVRII RRIKRDMEER GRSLDSVINQ YLGVVKPMYH QFIESTKRYA 190 200 210 DIVIPEGVSN TVAIDLLTTK IAKILEEARN SK

References

[1]	"Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hungary19A-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000936 Genomic DNA. Translation: ACA36975.1.
RefSeq	YP_001694645.1. NC_010380.1.
3D structure databases
ProteinModelPortal	B1IC10.
ModBase	Search...
Protein-protein interaction databases
STRING	487214.SPH_1326.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACA36975; ACA36975; SPH_1326.
GeneID	6029476.
KEGG	spv:SPH_1326.
PATRIC	19692758. VBIStrPne34925_1330.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0572.
HOGENOM	HOG000262756.
KO	K00876.
OMA	RKTVRPM.
ProtClustDB	PRK05480.
Enzyme and pathway databases
UniPathway	UPA00574; UER00637. UPA00579; UER00640.
Family and domain databases
HAMAP	MF_00551. Uridine_kinase.
InterPro	IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view]
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_STRPI

Accession

Primary (citable) accession number: B1IC10

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program