Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B1IBM3 (B1IBM3_STRPI) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111

EC=2.5.1.7 HAMAP-Rule MF_00111
Alternative name(s):
Enoylpyruvate transferase HAMAP-Rule MF_00111
UDP-N-acetylglucosamine enolpyruvyl transferase HAMAP-Rule MF_00111
Gene names
Name:murA HAMAP-Rule MF_00111
Synonyms:murA1 EMBL ACA37082.1
Ordered Locus Names:SPH_1173 EMBL ACA37082.1
OrganismStreptococcus pneumoniae (strain Hungary19A-6) [Complete proteome] [HAMAP] EMBL ACA37082.1
Taxonomic identifier487214 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. SAAS SAAS005750 HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. SAAS SAAS005750 HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005750 HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily. HAMAP-Rule MF_00111

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region22 – 232Citrate binding PDB 3ZH4

Sites

Active site1161Proton donor By similarity HAMAP-Rule MF_00111
Binding site921Citrate PDB 3ZH4
Binding site3061Citrate PDB 3ZH4
Binding site3321Citrate PDB 3ZH4
Binding site3721Citrate PDB 3ZH4
Binding site3981Citrate PDB 3ZH4

Amino acid modifications

Modified residue11612-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity HAMAP-Rule MF_00111

Sequences

Sequence LengthMass (Da)Tools
B1IBM3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: A217CD0CB16DF8F9

FASTA41945,055
        10         20         30         40         50         60 
MRKIVINGGL PLQGEITISG AKNSVVALIP AIILADDVVT LDCVPDISDV ASLVEIMELM 

        70         80         90        100        110        120 
GATVKRYDDV LEIDPRGVQN IPMPYGKINS LRASYYFYGS LLGRFGEATV GLPGGCDLGP 

       130        140        150        160        170        180 
RPIDLHLKAF EAMGATASYE GDNMKLSAKD TGLHGASIYM DTVSVGATIN TMIAAVKANG 

       190        200        210        220        230        240 
RTIIENAARE PEIIDVATLL NNMGAHIRGA GTNIIIIDGV ERLHGTRHQV IPDRIEAGTY 

       250        260        270        280        290        300 
ISLAAAVGKG IRINNVLYEH LEGFIAKLEE MGVRMTVSED SIFVEEQSNL KAINIKTAPY 

       310        320        330        340        350        360 
PGFATDLQQP LTPLLLRANG RGTIVDTIYE KRVNHVFELA KMDADISTTN GHILYTGGRD 

       370        380        390        400        410 
LRGTSVKATD LRAGAALVIA GLMAEGKTEI TNIEFILRGY SDIIEKLRNL GADIRLVED 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hungary19A-6.
[2]"Heteroresistance to fosfomycin is predominant in Streptococcus pneumoniae and depends on the murA1 gene."
Engel H., Gutierrez-Fernandez J., Fluckiger C., Martinez-Ripoll M., Muhlemann K., Hermoso J.A., Hilty M., Hathaway L.J.
Antimicrob. Agents Chemother. 57:2801-2808(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH CITRATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000936 Genomic DNA. Translation: ACA37082.1.
RefSeqYP_001694508.1. NC_010380.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZH4X-ray1.80A1-419[»]
ProteinModelPortalB1IBM3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING487214.SPH_1173.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA37082; ACA37082; SPH_1173.
GeneID6028603.
KEGGspv:SPH_1173.
PATRIC19692457. VBIStrPne34925_1180.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAGATIWRE.
OrthoDBEOG68M4GK.
ProtClustDBPRK12830.

Enzyme and pathway databases

BioCycSPNE487214:GHY0-1152-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1IBM3_STRPI
AccessionPrimary (citable) accession number: B1IBM3
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)