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B1IBM3

- B1IBM3_STRPI

UniProt

B1IBM3 - B1IBM3_STRPI

Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Gene

murA

Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotationSAAS annotation

    Catalytic activityi

    Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei92 – 921CitrateImported
    Active sitei116 – 1161Proton donorUniRule annotation
    Binding sitei306 – 3061CitrateImported
    Binding sitei332 – 3321CitrateImported
    Binding sitei372 – 3721CitrateImported
    Binding sitei398 – 3981CitrateImported

    GO - Molecular functioni

    1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW
    5. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    PyruvateUniRule annotation

    Enzyme and pathway databases

    BioCyciSPNE487214:GHY0-1152-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.7UniRule annotation)
    Alternative name(s):
    Enoylpyruvate transferaseUniRule annotation
    UDP-N-acetylglucosamine enolpyruvyl transferaseUniRule annotation
    Gene namesi
    Name:murAUniRule annotation
    Synonyms:murA1Imported
    Ordered Locus Names:SPH_1173Imported
    OrganismiStreptococcus pneumoniae (strain Hungary19A-6)Imported
    Taxonomic identifieri487214 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002163: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei116 – 11612-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi487214.SPH_1173.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZH4X-ray1.80A1-419[»]
    ProteinModelPortaliB1IBM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 232Citrate bindingImported

    Sequence similaritiesi

    Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0766.
    HOGENOMiHOG000075602.
    KOiK00790.
    OMAiGATIWRE.
    OrthoDBiEOG68M4GK.

    Family and domain databases

    Gene3Di3.65.10.10. 2 hits.
    HAMAPiMF_00111. MurA.
    InterProiIPR001986. Enolpyruvate_Tfrase_dom.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR005750. UDP_GlcNAc_COvinyl_MurA.
    [Graphical view]
    PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
    PfamiPF00275. EPSP_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR01072. murA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1IBM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKIVINGGL PLQGEITISG AKNSVVALIP AIILADDVVT LDCVPDISDV    50
    ASLVEIMELM GATVKRYDDV LEIDPRGVQN IPMPYGKINS LRASYYFYGS 100
    LLGRFGEATV GLPGGCDLGP RPIDLHLKAF EAMGATASYE GDNMKLSAKD 150
    TGLHGASIYM DTVSVGATIN TMIAAVKANG RTIIENAARE PEIIDVATLL 200
    NNMGAHIRGA GTNIIIIDGV ERLHGTRHQV IPDRIEAGTY ISLAAAVGKG 250
    IRINNVLYEH LEGFIAKLEE MGVRMTVSED SIFVEEQSNL KAINIKTAPY 300
    PGFATDLQQP LTPLLLRANG RGTIVDTIYE KRVNHVFELA KMDADISTTN 350
    GHILYTGGRD LRGTSVKATD LRAGAALVIA GLMAEGKTEI TNIEFILRGY 400
    SDIIEKLRNL GADIRLVED 419
    Length:419
    Mass (Da):45,055
    Last modified:April 29, 2008 - v1
    Checksum:iA217CD0CB16DF8F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000936 Genomic DNA. Translation: ACA37082.1.
    RefSeqiYP_001694508.1. NC_010380.1.

    Genome annotation databases

    EnsemblBacteriaiACA37082; ACA37082; SPH_1173.
    GeneIDi6028603.
    KEGGispv:SPH_1173.
    PATRICi19692457. VBIStrPne34925_1180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000936 Genomic DNA. Translation: ACA37082.1 .
    RefSeqi YP_001694508.1. NC_010380.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZH4 X-ray 1.80 A 1-419 [» ]
    ProteinModelPortali B1IBM3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 487214.SPH_1173.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA37082 ; ACA37082 ; SPH_1173 .
    GeneIDi 6028603.
    KEGGi spv:SPH_1173.
    PATRICi 19692457. VBIStrPne34925_1180.

    Phylogenomic databases

    eggNOGi COG0766.
    HOGENOMi HOG000075602.
    KOi K00790.
    OMAi GATIWRE.
    OrthoDBi EOG68M4GK.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci SPNE487214:GHY0-1152-MONOMER.

    Family and domain databases

    Gene3Di 3.65.10.10. 2 hits.
    HAMAPi MF_00111. MurA.
    InterProi IPR001986. Enolpyruvate_Tfrase_dom.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR005750. UDP_GlcNAc_COvinyl_MurA.
    [Graphical view ]
    PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
    Pfami PF00275. EPSP_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR01072. murA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hungary19A-6Imported.
    2. "Heteroresistance to fosfomycin is predominant in Streptococcus pneumoniae and depends on the murA1 gene."
      Engel H., Gutierrez-Fernandez J., Fluckiger C., Martinez-Ripoll M., Muhlemann K., Hermoso J.A., Hilty M., Hathaway L.J.
      Antimicrob. Agents Chemother. 57:2801-2808(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).

    Entry informationi

    Entry nameiB1IBM3_STRPI
    AccessioniPrimary (citable) accession number: B1IBM3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3