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Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Proton acceptorUniRule annotation1
Metal bindingi143ZincUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi180ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi85 – 88ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SPH_1121Imported
OrganismiStreptococcus pneumoniae (strain Hungary19A-6)Imported
Taxonomic identifieri487214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002163 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB1IBH7.
SMRiB1IBH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiKEQFGWI.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

B1IBH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYYRYGT MNSGKTIEIL KVAYNYEEQG KGVVIMTSAL DTRDGVGYVS
60 70 80 90 100
SRIGMKRPAL AIEETTDIFG YIRDLPEKPY CVLVDEAQFL KRHHVYDLAR
110 120 130 140 150
VVDELDIPVM AFGLKNDFRN ELFEGSKYLL LLADKIDEIK TICQYCKKKA
160 170 180 190
TMVLRTQDGL PVYDGEQIQI GGNETYISVC RKHYFAPMIT SNKEQNYDN
Length:199
Mass (Da):22,826
Last modified:April 29, 2008 - v1
Checksum:i7783172FEA395E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000936 Genomic DNA. Translation: ACA36035.1.
RefSeqiWP_000068144.1. NC_010380.1.

Genome annotation databases

EnsemblBacteriaiACA36035; ACA36035; SPH_1121.
KEGGispv:SPH_1121.

Similar proteinsi

Entry informationi

Entry nameiB1IBH7_STRPI
AccessioniPrimary (citable) accession number: B1IBH7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 27, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported