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B1IAP6

- THIM2_STRPI

UniProt

B1IAP6 - THIM2_STRPI

Protein

Hydroxyethylthiazole kinase 2

Gene

thiM2

Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411Substrate; via amide nitrogenUniRule annotation
    Binding sitei116 – 1161ATPUniRule annotation
    Binding sitei166 – 1661ATPUniRule annotation
    Binding sitei193 – 1931Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE487214:GHY0-792-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinase 2UniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinase 2UniRule annotation
    Short name:
    TH kinase 2UniRule annotation
    Short name:
    Thz kinase 2UniRule annotation
    Gene namesi
    Name:thiM2UniRule annotation
    Ordered Locus Names:SPH_0811
    OrganismiStreptococcus pneumoniae (strain Hungary19A-6)
    Taxonomic identifieri487214 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002163: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Hydroxyethylthiazole kinase 2PRO_0000383902Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi487214.SPH_0811.

    Structurei

    3D structure databases

    ProteinModelPortaliB1IAP6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiAKPIMAE.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1IAP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEFTNPFPI GSSSLIHCMT NEISCEMLAN GILALGCKPV MADDSREVLD    50
    FTKQSQALFI NLGHLSAEKE KAIRMAASYA NQSSLPMVVD AVGVTTSSIR 100
    KSLVKDLLDY RPTVLKGNMS EIRSLVGLKH HGVGVDASAK DQETEDLLQV 150
    LKDWCQTYPG MSFLVTGPKD LIVSKNQVAV LENGCTELDW ITGTGDLVGA 200
    LTAVFLSQGK TGFEASCLAV SYLNIAAEKI VVQGMGLEEF RYQVLNQLSL 250
    LRRDENWLDT IKGEVYE 267
    Length:267
    Mass (Da):29,186
    Last modified:April 29, 2008 - v1
    Checksum:i7A0741B88C4B3AE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000936 Genomic DNA. Translation: ACA36432.1.
    RefSeqiYP_001694181.1. NC_010380.1.

    Genome annotation databases

    EnsemblBacteriaiACA36432; ACA36432; SPH_0811.
    GeneIDi6030027.
    KEGGispv:SPH_0811.
    PATRICi19691728. VBIStrPne34925_0820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000936 Genomic DNA. Translation: ACA36432.1 .
    RefSeqi YP_001694181.1. NC_010380.1.

    3D structure databases

    ProteinModelPortali B1IAP6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 487214.SPH_0811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA36432 ; ACA36432 ; SPH_0811 .
    GeneIDi 6030027.
    KEGGi spv:SPH_0811.
    PATRICi 19691728. VBIStrPne34925_0820.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi AKPIMAE.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci SPNE487214:GHY0-792-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hungary19A-6.

    Entry informationi

    Entry nameiTHIM2_STRPI
    AccessioniPrimary (citable) accession number: B1IAP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3