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B1IAP6

- THIM2_STRPI

UniProt

B1IAP6 - THIM2_STRPI

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Protein
Hydroxyethylthiazole kinase 2
Gene
thiM2, SPH_0811
Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Substrate; via amide nitrogen By similarity
Binding sitei116 – 1161ATP By similarity
Binding sitei166 – 1661ATP By similarity
Binding sitei193 – 1931Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE487214:GHY0-792-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase 2 (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 2
Short name:
TH kinase 2
Short name:
Thz kinase 2
Gene namesi
Name:thiM2
Ordered Locus Names:SPH_0811
OrganismiStreptococcus pneumoniae (strain Hungary19A-6)
Taxonomic identifieri487214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002163: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Hydroxyethylthiazole kinase 2UniRule annotation
PRO_0000383902Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi487214.SPH_0811.

Structurei

3D structure databases

ProteinModelPortaliB1IAP6.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiAKPIMAE.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

B1IAP6-1 [UniParc]FASTAAdd to Basket

« Hide

MQEFTNPFPI GSSSLIHCMT NEISCEMLAN GILALGCKPV MADDSREVLD    50
FTKQSQALFI NLGHLSAEKE KAIRMAASYA NQSSLPMVVD AVGVTTSSIR 100
KSLVKDLLDY RPTVLKGNMS EIRSLVGLKH HGVGVDASAK DQETEDLLQV 150
LKDWCQTYPG MSFLVTGPKD LIVSKNQVAV LENGCTELDW ITGTGDLVGA 200
LTAVFLSQGK TGFEASCLAV SYLNIAAEKI VVQGMGLEEF RYQVLNQLSL 250
LRRDENWLDT IKGEVYE 267
Length:267
Mass (Da):29,186
Last modified:April 29, 2008 - v1
Checksum:i7A0741B88C4B3AE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000936 Genomic DNA. Translation: ACA36432.1.
RefSeqiYP_001694181.1. NC_010380.1.

Genome annotation databases

EnsemblBacteriaiACA36432; ACA36432; SPH_0811.
GeneIDi6030027.
KEGGispv:SPH_0811.
PATRICi19691728. VBIStrPne34925_0820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000936 Genomic DNA. Translation: ACA36432.1 .
RefSeqi YP_001694181.1. NC_010380.1.

3D structure databases

ProteinModelPortali B1IAP6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 487214.SPH_0811.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA36432 ; ACA36432 ; SPH_0811 .
GeneIDi 6030027.
KEGGi spv:SPH_0811.
PATRICi 19691728. VBIStrPne34925_0820.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi AKPIMAE.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci SPNE487214:GHY0-792-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hungary19A-6.

Entry informationi

Entry nameiTHIM2_STRPI
AccessioniPrimary (citable) accession number: B1IAP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 29, 2008
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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