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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi441 – 448GTPUniRule annotation8
Nucleotide bindingi487 – 491GTPUniRule annotation5
Nucleotide bindingi541 – 544GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE487214:G1GB4-659-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:SPH_0653
OrganismiStreptococcus pneumoniae (strain Hungary19A-6)
Taxonomic identifieri487214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000938321 – 930Translation initiation factor IF-2Add BLAST930

Proteomic databases

PRIDEiB1IA80

Structurei

3D structure databases

ProteinModelPortaliB1IA80
SMRiB1IA80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini432 – 599tr-type GAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni441 – 448G1By similarity8
Regioni466 – 470G2By similarity5
Regioni487 – 490G3By similarity4
Regioni541 – 544G4By similarity4
Regioni577 – 579G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076906
KOiK02519
OMAiDNRTGGY

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B IF_2_B, 1 hit
InterProiView protein in InterPro
IPR006847 IF2_N
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
PF04760 IF2_N, 2 hits
SUPFAMiSSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00487 IF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
PS01176 IF2, 1 hit

Sequencei

Sequence statusi: Complete.

B1IA80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKRLYEIA KELGKESKEV VARAKELGLD VKSHSSSVEE AVAAKIAASF
60 70 80 90 100
KPAAAPKVEA KPAAPKVSAE KKTEKSEPAK PAVAKEEAKP AEPVAPKTEK
110 120 130 140 150
VAAKPQSRNF KAEREARAKE QAERRKQNKG NNRDQQQNGN RQKNDGRNGG
160 170 180 190 200
KQGQSNRDNR RFNDQAKKQQ GQQKRRNERR QQEDKRSNQA APRIDFKARA
210 220 230 240 250
AALKAEQNAE YARSSEERFK QYQAAKEALA QANKRKEPEE IFEEAAKLAE
260 270 280 290 300
QAQQVQAVVE VVPEKKEPAV DTRRKKQARP DKNRDDYDHE EDGPRKQQKN
310 320 330 340 350
RSSQNQVRNQ KNSNWNNNKK NKKGNNKNNR NQTPKPVTER KFHELPTEFE
360 370 380 390 400
YTDGMTVAEI AKRIKREPAE IVKKLFMMGV MATQNQSLDG ETIELLMVDY
410 420 430 440 450
GIEAKQKVEV DNADIERFFV EDGYLNEDEL VERPPVVTIM GHVDHGKTTL
460 470 480 490 500
LDTLRNSRVA TGEAGGITQH IGAYQIVENG KKITFLDTPG HAAFTSMRAR
510 520 530 540 550
GASVTDITIL VVAADDGVMP QTIEAINHSK AVNVPIIVAI NKIDKPGANP
560 570 580 590 600
ERVIGELAEH GVMSTAWGGD SEFVEISAKF NQNIEELLET VLLVAEIQEL
610 620 630 640 650
KADPTVRAIG TVIEARLDKG KGAVATLLVQ QGTLNVQDPI VVGNTFGRVR
660 670 680 690 700
AMTNDLGRRV KVAGPSTPVS ITGLNEAPMA GDHFAVYEDE KSARAAGEER
710 720 730 740 750
AKRALMKQRQ ATQRVSLENL FDTLKAGELK SVNVIIKADV QGSVEALSAS
760 770 780 790 800
LQKIDVEGVK VTIVHSAVGA INESDVTLAE ASNAFIVGFN VRPTPQARQQ
810 820 830 840 850
AEADDVEIRL HSIIYKVIEE MEEAMKGMLD PEFEEKVIGE AVIRETFKVS
860 870 880 890 900
KVGTIGGFMV INGKVARDSK VRVIRDGVVI YDGELASLKH YKDDVKEVTN
910 920 930
GREGGLMIDG YNDIKMDDVI EAYVMEEIKR
Length:930
Mass (Da):102,965
Last modified:April 29, 2008 - v1
Checksum:iB23E7E1D4F6FCAA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000936 Genomic DNA Translation: ACA37465.1
RefSeqiWP_000039220.1, NC_010380.1

Genome annotation databases

EnsemblBacteriaiACA37465; ACA37465; SPH_0653
KEGGispv:SPH_0653

Entry informationi

Entry nameiIF2_STRPI
AccessioniPrimary (citable) accession number: B1IA80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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