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B1IA80 (IF2_STRPI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:SPH_0653
OrganismStreptococcus pneumoniae (strain Hungary19A-6) [Complete proteome] [HAMAP]
Taxonomic identifier487214 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length930 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 930930Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000093832

Regions

Nucleotide binding441 – 4488GTP By similarity
Nucleotide binding487 – 4915GTP By similarity
Nucleotide binding541 – 5444GTP By similarity
Region435 – 583149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
B1IA80 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: B23E7E1D4F6FCAA8

FASTA930102,965
        10         20         30         40         50         60 
MSKKRLYEIA KELGKESKEV VARAKELGLD VKSHSSSVEE AVAAKIAASF KPAAAPKVEA 

        70         80         90        100        110        120 
KPAAPKVSAE KKTEKSEPAK PAVAKEEAKP AEPVAPKTEK VAAKPQSRNF KAEREARAKE 

       130        140        150        160        170        180 
QAERRKQNKG NNRDQQQNGN RQKNDGRNGG KQGQSNRDNR RFNDQAKKQQ GQQKRRNERR 

       190        200        210        220        230        240 
QQEDKRSNQA APRIDFKARA AALKAEQNAE YARSSEERFK QYQAAKEALA QANKRKEPEE 

       250        260        270        280        290        300 
IFEEAAKLAE QAQQVQAVVE VVPEKKEPAV DTRRKKQARP DKNRDDYDHE EDGPRKQQKN 

       310        320        330        340        350        360 
RSSQNQVRNQ KNSNWNNNKK NKKGNNKNNR NQTPKPVTER KFHELPTEFE YTDGMTVAEI 

       370        380        390        400        410        420 
AKRIKREPAE IVKKLFMMGV MATQNQSLDG ETIELLMVDY GIEAKQKVEV DNADIERFFV 

       430        440        450        460        470        480 
EDGYLNEDEL VERPPVVTIM GHVDHGKTTL LDTLRNSRVA TGEAGGITQH IGAYQIVENG 

       490        500        510        520        530        540 
KKITFLDTPG HAAFTSMRAR GASVTDITIL VVAADDGVMP QTIEAINHSK AVNVPIIVAI 

       550        560        570        580        590        600 
NKIDKPGANP ERVIGELAEH GVMSTAWGGD SEFVEISAKF NQNIEELLET VLLVAEIQEL 

       610        620        630        640        650        660 
KADPTVRAIG TVIEARLDKG KGAVATLLVQ QGTLNVQDPI VVGNTFGRVR AMTNDLGRRV 

       670        680        690        700        710        720 
KVAGPSTPVS ITGLNEAPMA GDHFAVYEDE KSARAAGEER AKRALMKQRQ ATQRVSLENL 

       730        740        750        760        770        780 
FDTLKAGELK SVNVIIKADV QGSVEALSAS LQKIDVEGVK VTIVHSAVGA INESDVTLAE 

       790        800        810        820        830        840 
ASNAFIVGFN VRPTPQARQQ AEADDVEIRL HSIIYKVIEE MEEAMKGMLD PEFEEKVIGE 

       850        860        870        880        890        900 
AVIRETFKVS KVGTIGGFMV INGKVARDSK VRVIRDGVVI YDGELASLKH YKDDVKEVTN 

       910        920        930 
GREGGLMIDG YNDIKMDDVI EAYVMEEIKR 

« Hide

References

[1]"Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hungary19A-6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000936 Genomic DNA. Translation: ACA37465.1.
RefSeqYP_001694043.1. NC_010380.1.

3D structure databases

ProteinModelPortalB1IA80.
SMRB1IA80. Positions 705-824, 833-930.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING487214.SPH_0653.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA37465; ACA37465; SPH_0653.
GeneID6029517.
KEGGspv:SPH_0653.
PATRIC19691398. VBIStrPne34925_0655.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMAMKGQLEP.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycSPNE487214:GHY0-643-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_STRPI
AccessionPrimary (citable) accession number: B1IA80
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries