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B1IA80

- IF2_STRPI

UniProt

B1IA80 - IF2_STRPI

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi441 – 4488GTPUniRule annotation
Nucleotide bindingi487 – 4915GTPUniRule annotation
Nucleotide bindingi541 – 5444GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE487214:GHY0-643-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:SPH_0653
OrganismiStreptococcus pneumoniae (strain Hungary19A-6)
Taxonomic identifieri487214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002163: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930Translation initiation factor IF-2PRO_1000093832Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi487214.SPH_0653.

Structurei

3D structure databases

ProteinModelPortaliB1IA80.
SMRiB1IA80. Positions 705-824, 833-930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini432 – 599168tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni441 – 4488G1By similarity
Regioni466 – 4705G2By similarity
Regioni487 – 4904G3By similarity
Regioni541 – 5444G4By similarity
Regioni577 – 5793G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiIYKAIDD.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1IA80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKRLYEIA KELGKESKEV VARAKELGLD VKSHSSSVEE AVAAKIAASF
60 70 80 90 100
KPAAAPKVEA KPAAPKVSAE KKTEKSEPAK PAVAKEEAKP AEPVAPKTEK
110 120 130 140 150
VAAKPQSRNF KAEREARAKE QAERRKQNKG NNRDQQQNGN RQKNDGRNGG
160 170 180 190 200
KQGQSNRDNR RFNDQAKKQQ GQQKRRNERR QQEDKRSNQA APRIDFKARA
210 220 230 240 250
AALKAEQNAE YARSSEERFK QYQAAKEALA QANKRKEPEE IFEEAAKLAE
260 270 280 290 300
QAQQVQAVVE VVPEKKEPAV DTRRKKQARP DKNRDDYDHE EDGPRKQQKN
310 320 330 340 350
RSSQNQVRNQ KNSNWNNNKK NKKGNNKNNR NQTPKPVTER KFHELPTEFE
360 370 380 390 400
YTDGMTVAEI AKRIKREPAE IVKKLFMMGV MATQNQSLDG ETIELLMVDY
410 420 430 440 450
GIEAKQKVEV DNADIERFFV EDGYLNEDEL VERPPVVTIM GHVDHGKTTL
460 470 480 490 500
LDTLRNSRVA TGEAGGITQH IGAYQIVENG KKITFLDTPG HAAFTSMRAR
510 520 530 540 550
GASVTDITIL VVAADDGVMP QTIEAINHSK AVNVPIIVAI NKIDKPGANP
560 570 580 590 600
ERVIGELAEH GVMSTAWGGD SEFVEISAKF NQNIEELLET VLLVAEIQEL
610 620 630 640 650
KADPTVRAIG TVIEARLDKG KGAVATLLVQ QGTLNVQDPI VVGNTFGRVR
660 670 680 690 700
AMTNDLGRRV KVAGPSTPVS ITGLNEAPMA GDHFAVYEDE KSARAAGEER
710 720 730 740 750
AKRALMKQRQ ATQRVSLENL FDTLKAGELK SVNVIIKADV QGSVEALSAS
760 770 780 790 800
LQKIDVEGVK VTIVHSAVGA INESDVTLAE ASNAFIVGFN VRPTPQARQQ
810 820 830 840 850
AEADDVEIRL HSIIYKVIEE MEEAMKGMLD PEFEEKVIGE AVIRETFKVS
860 870 880 890 900
KVGTIGGFMV INGKVARDSK VRVIRDGVVI YDGELASLKH YKDDVKEVTN
910 920 930
GREGGLMIDG YNDIKMDDVI EAYVMEEIKR
Length:930
Mass (Da):102,965
Last modified:April 29, 2008 - v1
Checksum:iB23E7E1D4F6FCAA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000936 Genomic DNA. Translation: ACA37465.1.
RefSeqiYP_001694043.1. NC_010380.1.

Genome annotation databases

EnsemblBacteriaiACA37465; ACA37465; SPH_0653.
GeneIDi6029517.
KEGGispv:SPH_0653.
PATRICi19691398. VBIStrPne34925_0655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000936 Genomic DNA. Translation: ACA37465.1 .
RefSeqi YP_001694043.1. NC_010380.1.

3D structure databases

ProteinModelPortali B1IA80.
SMRi B1IA80. Positions 705-824, 833-930.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 487214.SPH_0653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA37465 ; ACA37465 ; SPH_0653 .
GeneIDi 6029517.
KEGGi spv:SPH_0653.
PATRICi 19691398. VBIStrPne34925_0655.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi IYKAIDD.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci SPNE487214:GHY0-643-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hungary19A-6.

Entry informationi

Entry nameiIF2_STRPI
AccessioniPrimary (citable) accession number: B1IA80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3