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B1IA80

- IF2_STRPI

UniProt

B1IA80 - IF2_STRPI

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi441 – 4488GTPUniRule annotation
    Nucleotide bindingi487 – 4915GTPUniRule annotation
    Nucleotide bindingi541 – 5444GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE487214:GHY0-643-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:SPH_0653
    OrganismiStreptococcus pneumoniae (strain Hungary19A-6)
    Taxonomic identifieri487214 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002163: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 930930Translation initiation factor IF-2PRO_1000093832Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi487214.SPH_0653.

    Structurei

    3D structure databases

    ProteinModelPortaliB1IA80.
    SMRiB1IA80. Positions 705-824, 833-930.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini432 – 599168tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni441 – 4488G1By similarity
    Regioni466 – 4705G2By similarity
    Regioni487 – 4904G3By similarity
    Regioni541 – 5444G4By similarity
    Regioni577 – 5793G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiIYKAIDD.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1IA80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKKRLYEIA KELGKESKEV VARAKELGLD VKSHSSSVEE AVAAKIAASF    50
    KPAAAPKVEA KPAAPKVSAE KKTEKSEPAK PAVAKEEAKP AEPVAPKTEK 100
    VAAKPQSRNF KAEREARAKE QAERRKQNKG NNRDQQQNGN RQKNDGRNGG 150
    KQGQSNRDNR RFNDQAKKQQ GQQKRRNERR QQEDKRSNQA APRIDFKARA 200
    AALKAEQNAE YARSSEERFK QYQAAKEALA QANKRKEPEE IFEEAAKLAE 250
    QAQQVQAVVE VVPEKKEPAV DTRRKKQARP DKNRDDYDHE EDGPRKQQKN 300
    RSSQNQVRNQ KNSNWNNNKK NKKGNNKNNR NQTPKPVTER KFHELPTEFE 350
    YTDGMTVAEI AKRIKREPAE IVKKLFMMGV MATQNQSLDG ETIELLMVDY 400
    GIEAKQKVEV DNADIERFFV EDGYLNEDEL VERPPVVTIM GHVDHGKTTL 450
    LDTLRNSRVA TGEAGGITQH IGAYQIVENG KKITFLDTPG HAAFTSMRAR 500
    GASVTDITIL VVAADDGVMP QTIEAINHSK AVNVPIIVAI NKIDKPGANP 550
    ERVIGELAEH GVMSTAWGGD SEFVEISAKF NQNIEELLET VLLVAEIQEL 600
    KADPTVRAIG TVIEARLDKG KGAVATLLVQ QGTLNVQDPI VVGNTFGRVR 650
    AMTNDLGRRV KVAGPSTPVS ITGLNEAPMA GDHFAVYEDE KSARAAGEER 700
    AKRALMKQRQ ATQRVSLENL FDTLKAGELK SVNVIIKADV QGSVEALSAS 750
    LQKIDVEGVK VTIVHSAVGA INESDVTLAE ASNAFIVGFN VRPTPQARQQ 800
    AEADDVEIRL HSIIYKVIEE MEEAMKGMLD PEFEEKVIGE AVIRETFKVS 850
    KVGTIGGFMV INGKVARDSK VRVIRDGVVI YDGELASLKH YKDDVKEVTN 900
    GREGGLMIDG YNDIKMDDVI EAYVMEEIKR 930
    Length:930
    Mass (Da):102,965
    Last modified:April 29, 2008 - v1
    Checksum:iB23E7E1D4F6FCAA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000936 Genomic DNA. Translation: ACA37465.1.
    RefSeqiYP_001694043.1. NC_010380.1.

    Genome annotation databases

    EnsemblBacteriaiACA37465; ACA37465; SPH_0653.
    GeneIDi6029517.
    KEGGispv:SPH_0653.
    PATRICi19691398. VBIStrPne34925_0655.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000936 Genomic DNA. Translation: ACA37465.1 .
    RefSeqi YP_001694043.1. NC_010380.1.

    3D structure databases

    ProteinModelPortali B1IA80.
    SMRi B1IA80. Positions 705-824, 833-930.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 487214.SPH_0653.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA37465 ; ACA37465 ; SPH_0653 .
    GeneIDi 6029517.
    KEGGi spv:SPH_0653.
    PATRICi 19691398. VBIStrPne34925_0655.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi IYKAIDD.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci SPNE487214:GHY0-643-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hungary19A-6.

    Entry informationi

    Entry nameiIF2_STRPI
    AccessioniPrimary (citable) accession number: B1IA80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3