B1I9P6 (UPPP_STRPI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	SPH_0565

Organism

Streptococcus pneumoniae (strain Hungary19A-6) [Complete proteome] [HAMAP]

Taxonomic identifier

487214 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000197411
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	152 – 172	21	Helical; Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	257 – 277	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B1I9P6 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 0575353B1BDF97C2	FASTA	281	31,810
	10 20 30 40 50 60 MYLIEILKSI FFGIVEGITE WLPISSTGHL ILAEEFIQYQ NQNEAFMSMF NVVIQLGAIL 70 80 90 100 110 120 AVMVIYFNKL NPFKPTKDKQ EVRKTWRLWL KVLIATLPLL GVFKFDDWFD THFHNMVSVA 130 140 150 160 170 180 LMLIIYGVAF IYLEKRNKAR AIEPSVTELD KLPYTTAFYI GLFQVLALLP GTSRSGATIV 190 200 210 220 230 240 GGLLNGTSRS VVTEFTFYLG IPVMFGASAL KIFKFVKAGE LLSFGQLFLL LVAMGVAFAV 250 260 270 280 SMVAIRFLTS YVKKHDFTLF GKYRIVLGSV LLLYSFVRLF V

References

[1]	"Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hungary19A-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000936 Genomic DNA. Translation: ACA37015.1.
RefSeq	YP_001693959.1. NC_010380.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	487214.SPH_0565.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACA37015; ACA37015; SPH_0565.
GeneID	6029961.
KEGG	spv:SPH_0565.
PATRIC	19691226. VBIStrPne34925_0568.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	LQIGLFQ.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_STRPI

Accession

Primary (citable) accession number: B1I9P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program