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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108NAD; via amide nitrogenUniRule annotation1
Binding sitei108SubstrateUniRule annotation1
Binding sitei143NAD; via amide nitrogenUniRule annotation1
Active sitei194Proton acceptorUniRule annotation1
Binding sitei258NADUniRule annotation1
Binding sitei284NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:SPH_2278
OrganismiStreptococcus pneumoniae (strain Hungary19A-6)
Taxonomic identifieri487214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002163 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001231961 – 338Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST338

Structurei

3D structure databases

ProteinModelPortaliB1I9F8
SMRiB1I9F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 259Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246854
KOiK00057
OMAiWLCKGFE

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

B1I9F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQTVAVLG PGSWGTALSQ VLNDNGHEVR IWGNLPEQIN EINTHHTNKH
60 70 80 90 100
YFKDVVLDEN IIAYTDLAET LKDVDAILFV VPTKVTRLVA QQVAQTLDHK
110 120 130 140 150
VIIMHASKGL EPDSHKRLST ILEEEIPEHL RSDIVVVSGP SHAEETIVRD
160 170 180 190 200
LTLITAASKD LQTAQYVQEL FSNHYFRLYT NTDVIGVETA GALKNIIAVG
210 220 230 240 250
AGALHGLGFG DNAKAAIIAR GLAEITRLGV ALGASPLTYS GLSGVGDLIV
260 270 280 290 300
TGTSIHSRNW RAGDALGRGE SLADIEANMG MVIEGISTTR AAYELAQELG
310 320 330
VYMPITQAIY QVIYHGTNIK DAIYDIMNNE FKAENEWS
Length:338
Mass (Da):36,778
Last modified:April 29, 2008 - v1
Checksum:i0C611D7B637B40C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000936 Genomic DNA Translation: ACA37417.1
RefSeqiWP_000415102.1, NC_010380.1

Genome annotation databases

EnsemblBacteriaiACA37417; ACA37417; SPH_2278
KEGGispv:SPH_2278

Similar proteinsi

Entry informationi

Entry nameiGPDA_STRPI
AccessioniPrimary (citable) accession number: B1I9F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health