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B1I998 (RNPA_STRPI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein component

Short name=RNase P protein
Short name=RNaseP protein
EC=3.1.26.5
Alternative name(s):
Protein C5
Gene names
Name:rnpA
Ordered Locus Names:SPH_2195
OrganismStreptococcus pneumoniae (strain Hungary19A-6) [Complete proteome] [HAMAP]
Taxonomic identifier487214 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length123 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity. HAMAP-Rule MF_00227

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00227

Subunit structure

Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit By similarity.

Sequence similarities

Belongs to the RnpA family.

Ontologies

Keywords
   Biological processtRNA processing
   LigandRNA-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-EC

tRNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 123123Ribonuclease P protein component HAMAP-Rule MF_00227
PRO_1000100398

Sequences

Sequence LengthMass (Da)Tools
B1I998 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 32A902586ED4F7BC

FASTA12314,253
        10         20         30         40         50         60 
MKKNFRVKRE KDFKAIFKEG TSFANRKFVV YQLENQKNHF RVGLSVSKKL GNAVTRNQIK 

        70         80         90        100        110        120 
RRIRHIIQNA KGSLVEDVDF VVIARKGVET LGYAEMEKNL LHVLKLSKIY QEGNGSEKET 


KVD 

« Hide

References

[1]"Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hungary19A-6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000936 Genomic DNA. Translation: ACA36438.1.
RefSeqYP_001695393.1. NC_010380.1.

3D structure databases

ProteinModelPortalB1I998.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING487214.SPH_2195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA36438; ACA36438; SPH_2195.
GeneID6029224.
KEGGspv:SPH_2195.
PATRIC19694547. VBIStrPne34925_2187.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0594.
HOGENOMHOG000266301.
KOK03536.
OMAVGHTAVM.
OrthoDBEOG6C01C6.

Enzyme and pathway databases

BioCycSPNE487214:GHY0-2159-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00227. RNase_P.
InterProIPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view]
PfamPF00825. Ribonuclease_P. 1 hit.
[Graphical view]
ProDomPD003629. Ribonuclease_P. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF54211. SSF54211. 1 hit.
TIGRFAMsTIGR00188. rnpA. 1 hit.
PROSITEPS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNPA_STRPI
AccessionPrimary (citable) accession number: B1I998
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families