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B1I814

- ASSY_STRPI

UniProt

B1I814 - ASSY_STRPI

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851CitrullineUniRule annotation
Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
Binding sitei117 – 1171AspartateUniRule annotation
Binding sitei121 – 1211AspartateUniRule annotation
Binding sitei121 – 1211CitrullineUniRule annotation
Binding sitei122 – 1221AspartateUniRule annotation
Binding sitei125 – 1251CitrullineUniRule annotation
Binding sitei173 – 1731CitrullineUniRule annotation
Binding sitei258 – 2581CitrullineUniRule annotation
Binding sitei270 – 2701CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE487214:GHY0-212-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:SPH_0215
OrganismiStreptococcus pneumoniae (strain Hungary19A-6)
Taxonomic identifieri487214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002163: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Argininosuccinate synthasePRO_1000089055Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi487214.SPH_0215.

Structurei

3D structure databases

ProteinModelPortaliB1I814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPECEYIR.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1I814-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKEKVILAY SGGLDTSVAI TWLKKDYDVV SVCMDVGEGK DLDFIHDKAL
60 70 80 90 100
KVGAVESYVI DVKDEFATDY VLVAHQSHAY YEQKYPLVSA LSRPLISKKL
110 120 130 140 150
VEIAHQIGAT TIAHGCTGKG NDQVRFEVSI AALDLNLKVI APVREWKWSR
160 170 180 190 200
EEEIYYAKEN GVPVPADLDN PYSVDQNLWG RANECGILEN PWNQAPEEAF
210 220 230 240 250
GITTSPEQAP DMPEYIEIEF SEGVPVSLNG EVLKLADLIQ KLNEIAGKHG
260 270 280 290 300
VGRIDHVENR LVGIKSREIY ECPGAVTLLT AHKEIEDLTL VREVAHFKPI
310 320 330 340 350
IENELSNLIY NALWFSSATQ ALIAYIKETQ KVVNGTAKVK LYKGSAQVVA
360 370 380 390
RKSPSSLYDE NLATYTSADT FDQDAAVGFI KLWGLPTKVH SEVQKSAK
Length:398
Mass (Da):44,081
Last modified:April 29, 2008 - v1
Checksum:iBC55990A6F10788B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000936 Genomic DNA. Translation: ACA36199.1.
RefSeqiYP_001693635.1. NC_010380.1.

Genome annotation databases

EnsemblBacteriaiACA36199; ACA36199; SPH_0215.
GeneIDi6029570.
KEGGispv:SPH_0215.
PATRICi19690506. VBIStrPne34925_0206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000936 Genomic DNA. Translation: ACA36199.1 .
RefSeqi YP_001693635.1. NC_010380.1.

3D structure databases

ProteinModelPortali B1I814.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 487214.SPH_0215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA36199 ; ACA36199 ; SPH_0215 .
GeneIDi 6029570.
KEGGi spv:SPH_0215.
PATRICi 19690506. VBIStrPne34925_0206.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi PECEYIR.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SPNE487214:GHY0-212-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hungary19A-6.

Entry informationi

Entry nameiASSY_STRPI
AccessioniPrimary (citable) accession number: B1I814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3