B1I7S9 (TRPC_STRPI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	SPH_1936

Organism

Streptococcus pneumoniae (strain Hungary19A-6) [Complete proteome] [HAMAP]

Taxonomic identifier

487214 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000095898

Sequences

	Sequence		Length	Mass (Da)
	B1I7S9 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: E49F8328DDD1A64A	FASTA	255	28,965
	10 20 30 40 50 60 MSQEFLARIL EQKAREVEQM KLEQIQPLRQ TYRLAEFLKN HQDRLQVIAE VKKASPSLGD 70 80 90 100 110 120 INLDVDIVQQ AQTYEENGAV MISVLTDEVF FKGHLDYLRE ISSQVEIPTL NKDFIIDEKQ 130 140 150 160 170 180 IIRARNAGAT VILLIVAALA EERLKELYDY ATVLGLEVLV ETHNLAELEV AHRLGAQIIG 190 200 210 220 230 240 VNNRNLTTFE VDLQTSVDLA KHFKDDCLYI SESAIFTRQD AERLAPYFNG ILVGTALMQA 250 ENVVQRIKEL QIDKG

References

[1]	"Complete sequence of Streptococcus pneumoniae strain Hungary 19A-6." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hungary19A-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000936 Genomic DNA. Translation: ACA36507.1.
RefSeq	YP_001695191.1. NC_010380.1.
3D structure databases
ProteinModelPortal	B1I7S9.
ModBase	Search...
Protein-protein interaction databases
STRING	B1I7S9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000023197; EBSTRP00000022363; EBSTRG00000023197.
GeneID	6029278.
GenomeReviews	Gene locus SPH_1936 in contig CP000936_GR.
KEGG	spv:SPH_1936.
PATRIC	19694001. VBIStrPne34925_1951.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000029214.
HOGENOM	HBG540956.
OMA	FETDINT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	SPNE487214:SPH_1936-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STRPI

Accession

Primary (citable) accession number: B1I7S9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program