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B1I5R7

- SYL_DESAP

UniProt

B1I5R7 - SYL_DESAP

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulforudis audaxviator (strain MP104C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDAUD477974:GH0B-1912-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Daud_1865
OrganismiDesulforudis audaxviator (strain MP104C)
Taxonomic identifieri477974 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis
ProteomesiUP000008544: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 826826Leucine--tRNA ligasePRO_1000091313Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi477974.Daud_1865.

Structurei

3D structure databases

ProteinModelPortaliB1I5R7.
SMRiB1I5R7. Positions 3-761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1I5R7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEKYVFAEI EEKLRRRWET EGIYHVPDFS NRPKYYCLEM FPYPSGNLHM
60 70 80 90 100
GHVRNYAIGD VVARFKTMRG YDVLHPMGWD AFGLPAENAA IQHGVPPARW
110 120 130 140 150
TWDNINVMRT QLKLLGVSYD WRRELATCHP GYYRWTQWLF LQFYHRGLAY
160 170 180 190 200
KAKAPVNWCP SCATVLANEQ VVAGGCERCK TAVERRELEQ WFFRITAYAD
210 220 230 240 250
RLLKDLAKLP GWPEKVKVMQ ENWIGRSTGA EIAFPLAGTD EAIRVFTTRP
260 270 280 290 300
DTLGGVTYMT IAPEHPLVSR VTTPEHRAAV EAFTERARSL SELDRTAGEH
310 320 330 340 350
EKEGLFTGAY CVNPLTGEQV PVFVANYVLM EYGTGCVMGV PAHDQRDFEF
360 370 380 390 400
ARKYGLPVRV VIQPEGDLLD GDTMSQAYTG PGRLVNTPGF DRMANAEAIP
410 420 430 440 450
AITRYLEARG AARFQVQYRL RDWLISRQRY WGAPIPIVYC EGCGVVPVPE
460 470 480 490 500
EGLPVLLPED VAFKPTGRSP LTESPDFVNT TCPTCGGPAR RETDTMDTFM
510 520 530 540 550
CSSWYYFRFT SPREENGPWG LERVDRWLPV DQYIGGVEHA ILHLMYSRFF
560 570 580 590 600
TKVLYDMGLV KVQEPFTNLL TQGMVLKDGA KMSKSKGNVV SPEDILNRYG
610 620 630 640 650
ADTTRLFVLF AAPPERDLEW SDQGVEGCYR FLQRVWRLVN SVADEIRGAA
660 670 680 690 700
PVPSANLVGV NRSMRRLTHQ TIKKVTEDIE TRFNFNTAIS AAMELVNGMY
710 720 730 740 750
HFRDRVAPVN RDPAVMREAV ERLLLLLAPF APFLADELWA RTGHPESIHR
760 770 780 790 800
EPWPEYDPEL LVEDQVEIVV QINGRVRDRL MVAADIAPEA MRDTVLEQPR
810 820
VQALVAGKEI VKVVPVPGKL VNIVVR
Length:826
Mass (Da):93,865
Last modified:April 29, 2008 - v1
Checksum:i6363D3EDDC6C95AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000860 Genomic DNA. Translation: ACA60358.1.
RefSeqiYP_001717990.1. NC_010424.1.

Genome annotation databases

EnsemblBacteriaiACA60358; ACA60358; Daud_1865.
GeneIDi6027550.
KEGGidau:Daud_1865.
PATRICi31970606. VBICanDes92303_1923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000860 Genomic DNA. Translation: ACA60358.1 .
RefSeqi YP_001717990.1. NC_010424.1.

3D structure databases

ProteinModelPortali B1I5R7.
SMRi B1I5R7. Positions 3-761.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 477974.Daud_1865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA60358 ; ACA60358 ; Daud_1865 .
GeneIDi 6027550.
KEGGi dau:Daud_1865.
PATRICi 31970606. VBICanDes92303_1923.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DAUD477974:GH0B-1912-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Desulforudis audaxviator MP104C."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MP104C.

Entry informationi

Entry nameiSYL_DESAP
AccessioniPrimary (citable) accession number: B1I5R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3