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B1I545

- DAPF_DESAP

UniProt

B1I545 - DAPF_DESAP

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Desulforudis audaxviator (strain MP104C)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei45 – 451SubstrateUniRule annotation
    Binding sitei63 – 631SubstrateUniRule annotation
    Active sitei72 – 721Proton donor/acceptorUniRule annotation
    Binding sitei160 – 1601SubstrateUniRule annotation
    Sitei162 – 1621Important for catalytic activityUniRule annotation
    Binding sitei193 – 1931SubstrateUniRule annotation
    Sitei211 – 2111Important for catalytic activityUniRule annotation
    Active sitei220 – 2201Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciDAUD477974:GH0B-1648-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:Daud_1604
    OrganismiDesulforudis audaxviator (strain MP104C)
    Taxonomic identifieri477974 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis
    ProteomesiUP000008544: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Diaminopimelate epimerasePRO_1000099231Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi72 ↔ 220

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi477974.Daud_1604.

    Structurei

    3D structure databases

    ProteinModelPortaliB1I545.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni8 – 92Substrate bindingUniRule annotation
    Regioni72 – 743Substrate bindingUniRule annotation
    Regioni211 – 2122Substrate bindingUniRule annotation
    Regioni221 – 2222Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220467.
    KOiK01778.
    OMAiRPAENGA.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1I545-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFTKMHGLG NDFVIVNGFG QSLPDDPGAL ARRVCDRRLG VGADGLVLLL    50
    PSAAADLRMR VFNPDGSEPE MCGNAIRCVA LYARRRGLVA KTQLEVETLA 100
    GLIRPEILLD GDRETVRVDM GRPRLERAEI PMRGPAGPVV GEVLDAGERS 150
    FMVTAVSMGN PHCVVFGADL DDAGFRKYGP LLEVHPAFPA RTNVEFVEVL 200
    SPGEVAVRVW ERGVGPTPAC GTGACAVAVA GVLTGRTARR VHVRLPGGVL 250
    LIEWPDDAGP VYMSGPAEEV FDGKWVRA 278
    Length:278
    Mass (Da):29,718
    Last modified:April 29, 2008 - v1
    Checksum:iB6A521D992514291
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000860 Genomic DNA. Translation: ACA60106.1.
    RefSeqiWP_012302687.1. NC_010424.1.
    YP_001717738.1. NC_010424.1.

    Genome annotation databases

    EnsemblBacteriaiACA60106; ACA60106; Daud_1604.
    GeneIDi6025767.
    KEGGidau:Daud_1604.
    PATRICi31970078. VBICanDes92303_1661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000860 Genomic DNA. Translation: ACA60106.1 .
    RefSeqi WP_012302687.1. NC_010424.1.
    YP_001717738.1. NC_010424.1.

    3D structure databases

    ProteinModelPortali B1I545.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 477974.Daud_1604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA60106 ; ACA60106 ; Daud_1604 .
    GeneIDi 6025767.
    KEGGi dau:Daud_1604.
    PATRICi 31970078. VBICanDes92303_1661.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220467.
    KOi K01778.
    OMAi RPAENGA.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci DAUD477974:GH0B-1648-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Desulforudis audaxviator MP104C."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MP104C.

    Entry informationi

    Entry nameiDAPF_DESAP
    AccessioniPrimary (citable) accession number: B1I545
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3