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B1I545

- DAPF_DESAP

UniProt

B1I545 - DAPF_DESAP

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Protein
Diaminopimelate epimerase
Gene
dapF, Daud_1604
Organism
Desulforudis audaxviator (strain MP104C)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei45 – 451Substrate By similarity
Binding sitei63 – 631Substrate By similarity
Active sitei72 – 721Proton donor/acceptor By similarity
Binding sitei160 – 1601Substrate By similarity
Sitei162 – 1621Important for catalytic activity By similarity
Binding sitei193 – 1931Substrate By similarity
Sitei211 – 2111Important for catalytic activity By similarity
Active sitei220 – 2201Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciDAUD477974:GH0B-1648-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:Daud_1604
OrganismiDesulforudis audaxviator (strain MP104C)
Taxonomic identifieri477974 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis
ProteomesiUP000008544: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Diaminopimelate epimeraseUniRule annotation
PRO_1000099231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 220UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi477974.Daud_1604.

Structurei

3D structure databases

ProteinModelPortaliB1I545.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 92Substrate binding By similarity
Regioni72 – 743Substrate binding By similarity
Regioni211 – 2122Substrate binding By similarity
Regioni221 – 2222Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220467.
KOiK01778.
OMAiRPAENGA.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1I545-1 [UniParc]FASTAAdd to Basket

« Hide

MEFTKMHGLG NDFVIVNGFG QSLPDDPGAL ARRVCDRRLG VGADGLVLLL    50
PSAAADLRMR VFNPDGSEPE MCGNAIRCVA LYARRRGLVA KTQLEVETLA 100
GLIRPEILLD GDRETVRVDM GRPRLERAEI PMRGPAGPVV GEVLDAGERS 150
FMVTAVSMGN PHCVVFGADL DDAGFRKYGP LLEVHPAFPA RTNVEFVEVL 200
SPGEVAVRVW ERGVGPTPAC GTGACAVAVA GVLTGRTARR VHVRLPGGVL 250
LIEWPDDAGP VYMSGPAEEV FDGKWVRA 278
Length:278
Mass (Da):29,718
Last modified:April 29, 2008 - v1
Checksum:iB6A521D992514291
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000860 Genomic DNA. Translation: ACA60106.1.
RefSeqiWP_012302687.1. NC_010424.1.
YP_001717738.1. NC_010424.1.

Genome annotation databases

EnsemblBacteriaiACA60106; ACA60106; Daud_1604.
GeneIDi6025767.
KEGGidau:Daud_1604.
PATRICi31970078. VBICanDes92303_1661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000860 Genomic DNA. Translation: ACA60106.1 .
RefSeqi WP_012302687.1. NC_010424.1.
YP_001717738.1. NC_010424.1.

3D structure databases

ProteinModelPortali B1I545.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 477974.Daud_1604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA60106 ; ACA60106 ; Daud_1604 .
GeneIDi 6025767.
KEGGi dau:Daud_1604.
PATRICi 31970078. VBICanDes92303_1661.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220467.
KOi K01778.
OMAi RPAENGA.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci DAUD477974:GH0B-1648-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Desulforudis audaxviator MP104C."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MP104C.

Entry informationi

Entry nameiDAPF_DESAP
AccessioniPrimary (citable) accession number: B1I545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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