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B1I396 (B1I396_DESAP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dut HAMAP MF_00116
Ordered Locus Names:Daud_0937
OrganismDesulforudis audaxviator (strain MP104C) [Complete proteome] [HAMAP] EMBL ACA59450.1
Taxonomic identifier477974 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Candidatus Desulforudis

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116

Cofactor

Magnesium By similarity. HAMAP MF_00116

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region75 – 773Substrate binding By similarity HAMAP MF_00116
Region92 – 943Substrate binding By similarity HAMAP MF_00116

Sites

Binding site881Substrate By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
B1I396 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 7DD400E0B17F0F73

FASTA15515,937
        10         20         30         40         50         60 
MAEVTRIVLR VKKLNPTIGK SWPGPAYATS GAAGLDLCAA LDSSLTIAPG ERVQIPTGIA 

        70         80         90        100        110        120 
VQLPERNLVG LVFGRSGLAA RHGITLANGV GVIDADYTGE IICPVVNHGT EPFTLSPGDR 

       130        140        150 
IAQLVCVPIA VAEVEYVFEL AETARGAGGF GSTGK

« Hide

References

[1]"Complete sequence of chromosome of Desulforudis audaxviator MP104C."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000860 Genomic DNA. Translation: ACA59450.1.
RefSeqYP_001717082.1. NC_010424.1.

3D structure databases

ProteinModelPortalB1I396.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1I396.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6026955.
GenomeReviewsGene locus Daud_0937 in contig CP000860_GR.
KEGGdau:Daud_0937.
PATRIC31968643. VBICanDes92303_0965.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG436079.
OMALDLRACI.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1I396_DESAP
AccessionPrimary (citable) accession number: B1I396
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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