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B1I393

- PNP_DESAP

UniProt

B1I393 - PNP_DESAP

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Daud_0934
Organism
Desulforudis audaxviator (strain MP104C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi496 – 4961Magnesium By similarity
Metal bindingi502 – 5021Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDAUD477974:GH0B-956-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Daud_0934
OrganismiDesulforudis audaxviator (strain MP104C)
Taxonomic identifieri477974 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis
ProteomesiUP000008544: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 741741Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000381884Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi477974.Daud_0934.

Structurei

3D structure databases

ProteinModelPortaliB1I393.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini563 – 62260KH
Add
BLAST
Domaini632 – 70675S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiISMEDTH.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1I393-1 [UniParc]FASTAAdd to Basket

« Hide

MTEQGYITRT IEISGRTFSV DIGRVAGQAS AGVLARYGET VVLVAATREA    50
LREGLDFFPL TVDYEERHYA VGRIPGSFMK REGRPGEKAI LAARLIDRSI 100
RPLFPRNFTQ DVHVVALVMS VDQDCSPAIT AILGASVALT LSDIPFAGPV 150
GAVIMGMVDG QLVVNPTLEQ DEKSDLHLTV AGTREAINMV EAGAKEVSEE 200
IIVEALTKAH AEIQRIAEWV GEIRAEVEPL GLAHPKIEVP ANEPGPELVE 250
AVRSAGYEKM RAAVHHCKNE RLDKKSADRH LEGTKAEIIN AVLENFPEEE 300
QRLKSLVDKL EKEAVRELVL KEKVRLDGRA FDEIRDISVE VNVLPRTHGS 350
GLFQRGQTQV LSVLTLGAVR DEQILDGLDT QETKRFMHHY NFPSFSTGEA 400
RPIRSAGRRE IGHGALAGRA LEAVLPGEDV FPYTIRIVSE VLSSNGSTSM 450
ASVCGSCLAL MDAGVPIKAP VAGIAMGLIK EGDEVAVLTD IQGTEDHLGD 500
MDFKVAGTEQ GVTALQMDIK IAGITPEILA QAMAQAREAR LYILDRYKEV 550
IPGPRPEISP RAPRIIHTTI DPEKIRDIIG PGGKIIRKIT ETTGVDIDVE 600
DDGRVFITAP DPEGGKKALE IIKTLTAEVK VGEVYLGRVV KIMDFGCFVE 650
VIPGVLGLPG KDGLVHISHL AHNRVRKVED VVREGDQILV KAIGFDNQGR 700
LKLSKKEAME PPAGGAGETG RPGLIQDDRP DRRPRSRFSR R 741
Length:741
Mass (Da):80,651
Last modified:April 29, 2008 - v1
Checksum:i1EDC3A62730240C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000860 Genomic DNA. Translation: ACA59447.1.
RefSeqiWP_012302033.1. NC_010424.1.
YP_001717079.1. NC_010424.1.

Genome annotation databases

EnsemblBacteriaiACA59447; ACA59447; Daud_0934.
GeneIDi6027568.
KEGGidau:Daud_0934.
PATRICi31968637. VBICanDes92303_0962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000860 Genomic DNA. Translation: ACA59447.1 .
RefSeqi WP_012302033.1. NC_010424.1.
YP_001717079.1. NC_010424.1.

3D structure databases

ProteinModelPortali B1I393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 477974.Daud_0934.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA59447 ; ACA59447 ; Daud_0934 .
GeneIDi 6027568.
KEGGi dau:Daud_0934.
PATRICi 31968637. VBICanDes92303_0962.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi ISMEDTH.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DAUD477974:GH0B-956-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Desulforudis audaxviator MP104C."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MP104C.

Entry informationi

Entry nameiPNP_DESAP
AccessioniPrimary (citable) accession number: B1I393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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