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B1I393

- PNP_DESAP

UniProt

B1I393 - PNP_DESAP

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Desulforudis audaxviator (strain MP104C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi496 – 4961MagnesiumUniRule annotation
    Metal bindingi502 – 5021MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciDAUD477974:GH0B-956-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Daud_0934
    OrganismiDesulforudis audaxviator (strain MP104C)
    Taxonomic identifieri477974 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis
    ProteomesiUP000008544: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 741741Polyribonucleotide nucleotidyltransferasePRO_0000381884Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi477974.Daud_0934.

    Structurei

    3D structure databases

    ProteinModelPortaliB1I393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini563 – 62260KHUniRule annotationAdd
    BLAST
    Domaini632 – 70675S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiISMEDTH.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1I393-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEQGYITRT IEISGRTFSV DIGRVAGQAS AGVLARYGET VVLVAATREA    50
    LREGLDFFPL TVDYEERHYA VGRIPGSFMK REGRPGEKAI LAARLIDRSI 100
    RPLFPRNFTQ DVHVVALVMS VDQDCSPAIT AILGASVALT LSDIPFAGPV 150
    GAVIMGMVDG QLVVNPTLEQ DEKSDLHLTV AGTREAINMV EAGAKEVSEE 200
    IIVEALTKAH AEIQRIAEWV GEIRAEVEPL GLAHPKIEVP ANEPGPELVE 250
    AVRSAGYEKM RAAVHHCKNE RLDKKSADRH LEGTKAEIIN AVLENFPEEE 300
    QRLKSLVDKL EKEAVRELVL KEKVRLDGRA FDEIRDISVE VNVLPRTHGS 350
    GLFQRGQTQV LSVLTLGAVR DEQILDGLDT QETKRFMHHY NFPSFSTGEA 400
    RPIRSAGRRE IGHGALAGRA LEAVLPGEDV FPYTIRIVSE VLSSNGSTSM 450
    ASVCGSCLAL MDAGVPIKAP VAGIAMGLIK EGDEVAVLTD IQGTEDHLGD 500
    MDFKVAGTEQ GVTALQMDIK IAGITPEILA QAMAQAREAR LYILDRYKEV 550
    IPGPRPEISP RAPRIIHTTI DPEKIRDIIG PGGKIIRKIT ETTGVDIDVE 600
    DDGRVFITAP DPEGGKKALE IIKTLTAEVK VGEVYLGRVV KIMDFGCFVE 650
    VIPGVLGLPG KDGLVHISHL AHNRVRKVED VVREGDQILV KAIGFDNQGR 700
    LKLSKKEAME PPAGGAGETG RPGLIQDDRP DRRPRSRFSR R 741
    Length:741
    Mass (Da):80,651
    Last modified:April 29, 2008 - v1
    Checksum:i1EDC3A62730240C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000860 Genomic DNA. Translation: ACA59447.1.
    RefSeqiWP_012302033.1. NC_010424.1.
    YP_001717079.1. NC_010424.1.

    Genome annotation databases

    EnsemblBacteriaiACA59447; ACA59447; Daud_0934.
    GeneIDi6027568.
    KEGGidau:Daud_0934.
    PATRICi31968637. VBICanDes92303_0962.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000860 Genomic DNA. Translation: ACA59447.1 .
    RefSeqi WP_012302033.1. NC_010424.1.
    YP_001717079.1. NC_010424.1.

    3D structure databases

    ProteinModelPortali B1I393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 477974.Daud_0934.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA59447 ; ACA59447 ; Daud_0934 .
    GeneIDi 6027568.
    KEGGi dau:Daud_0934.
    PATRICi 31968637. VBICanDes92303_0962.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi ISMEDTH.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci DAUD477974:GH0B-956-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Desulforudis audaxviator MP104C."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MP104C.

    Entry informationi

    Entry nameiPNP_DESAP
    AccessioniPrimary (citable) accession number: B1I393
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3