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B1I2Y8 (UPPP_DESAP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Daud_0835
OrganismDesulforudis audaxviator (strain MP104C) [Complete proteome] [HAMAP]
Taxonomic identifier477974 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197362

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B1I2Y8 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 078C5906A26B2D1B

FASTA26128,373
        10         20         30         40         50         60 
MNPFEGIVMG IVQGLTEFLP VSSSAHLVLV PWLFGFETPG LVFDVALHLG TLVAVLVYFW 

        70         80         90        100        110        120 
RDWLRLVQAG SRGVGTADGR LFWFLVVATI PGVVVGYFLE DIVETTLRAP LLIGVLLIMM 

       130        140        150        160        170        180 
GGVLYLADRY GGQVKRLLDI RFGDAMAIGL SQALAIIPGV SRSGITMATA RLRGVERAAA 

       190        200        210        220        230        240 
ARFSFLLSTP IIFGAGLMQM LKMDPGLLNL SFVLGVFTSA VVGFLAIWFL ISWVSRHSFN 

       250        260 
IFVIYRVLLG LTVIVIALLR G 

« Hide

References

[1]"Complete sequence of chromosome of Desulforudis audaxviator MP104C."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MP104C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000860 Genomic DNA. Translation: ACA59349.1.
RefSeqYP_001716981.1. NC_010424.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING477974.Daud_0835.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA59349; ACA59349; Daud_0835.
GeneID6026329.
KEGGdau:Daud_0835.
PATRIC31968423. VBICanDes92303_0859.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAEYLFHER.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycDAUD477974:GH0B-853-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_DESAP
AccessionPrimary (citable) accession number: B1I2Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families