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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Desulforudis audaxviator (strain MP104C)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation

Enzyme and pathway databases

BioCyciDAUD477974:GH0B-791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:Daud_0773Imported
OrganismiDesulforudis audaxviator (strain MP104C)Imported
Taxonomic identifieri477974 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis
ProteomesiUP000008544: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi477974.Daud_0773.

Structurei

3D structure databases

ProteinModelPortaliB1I2W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000038601.
KOiK01595.
OMAiQSSFKYD.
OrthoDBiEOG6WDSG0.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

B1I2W1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTQRKISRT MSTQHPDNVT VPFFANSQDM SGEDEIQEAY YVISHLQCQE
60 70 80 90 100
QMWDCEGKEV DNFVVRKLLT QYEHFFAHNR LGRDVFLTLR VPNPTVEHTE
110 120 130 140 150
GKVLIETLQS IPRSFDAARL VYGEEIPPIF EVILPMTTSH KCLNRVYYFY
160 170 180 190 200
KDFVAGRQTL PFYPGDISIA EWVGDFKPEE INVIPLFEDR HHMLEAAAIL
210 220 230 240 250
RRYLENKPFT YQRVFLARSD PALNYGMISA VLLNKVALQR LAALEKETGV
260 270 280 290 300
EIYPILGVGS APFRGNLKPH TVERVLAEYP DVQTFTIQSA FKYDYPVTTV
310 320 330 340 350
LEGIRKINAA SRGQAGEVDA ERCIRIIDSV SRAYASKVRV LAPVVNYVAS
360 370 380 390 400
AIPPRRKRKL HIGLFGYARK TSGVSLPRAI GFCAACYSIG LPPELLGYAG
410 420 430 440 450
LDKEDARYLQ TVYHQLDQDL EDALPFFNED VFKLVPELRH LLRTELFPFR
460 470 480
ADEEHRKITS RIIKAVREDR REGLTHLILE AGYLRGFLG
Length:489
Mass (Da):55,920
Last modified:April 29, 2008 - v1
Checksum:i4E76C2E5702FDD67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000860 Genomic DNA. Translation: ACA59295.1.
RefSeqiWP_012301881.1. NC_010424.1.
YP_001716927.1. NC_010424.1.

Genome annotation databases

EnsemblBacteriaiACA59295; ACA59295; Daud_0773.
GeneIDi6025695.
KEGGidau:Daud_0773.
PATRICi31968297. VBICanDes92303_0796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000860 Genomic DNA. Translation: ACA59295.1.
RefSeqiWP_012301881.1. NC_010424.1.
YP_001716927.1. NC_010424.1.

3D structure databases

ProteinModelPortaliB1I2W1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi477974.Daud_0773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA59295; ACA59295; Daud_0773.
GeneIDi6025695.
KEGGidau:Daud_0773.
PATRICi31968297. VBICanDes92303_0796.

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000038601.
KOiK01595.
OMAiQSSFKYD.
OrthoDBiEOG6WDSG0.

Enzyme and pathway databases

BioCyciDAUD477974:GH0B-791-MONOMER.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Desulforudis audaxviator MP104C."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MP104CImported.

Entry informationi

Entry nameiB1I2W1_DESAP
AccessioniPrimary (citable) accession number: B1I2W1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.