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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Desulforudis audaxviator (strain MP104C)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciCDES477974:G1GAD-627-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Daud_0601
OrganismiDesulforudis audaxviator (strain MP104C)
Taxonomic identifieri477974 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis
Proteomesi
  • UP000008544 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003463331 – 439Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST439

Proteomic databases

PRIDEiB1I258

Interactioni

Protein-protein interaction databases

STRINGi477974.Daud_0601

Structurei

3D structure databases

ProteinModelPortaliB1I258
SMRiB1I258
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108FW6 Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP
OrthoDBiPOG091H00B3

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit

Sequencei

Sequence statusi: Complete.

B1I258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGVIVVGA GLAGAEASWQ LVRRGVPVVL YEMRPRKCTP AHKTGDFAEL
60 70 80 90 100
VCSNSLRAEA LTNAVGLLKE EMRRLGSLIM ACADAHRVPA GGALAVDRQL
110 120 130 140 150
FAAAVTERLT SHRLVTVCRE EITTIPTAEL VILATGPLTS DALADELRRL
160 170 180 190 200
TGQEHLYFFD AVAPIVTLES IDQDRVFRSS RYGRGDPAYL NCPMSREEYE
210 220 230 240 250
RFWEALVAAE RATRHTFERE THFEGCLPVE VIAARGRETL LYGPLKPVGL
260 270 280 290 300
VDPRTGERPY AVVQLRQDNR AGTLYNLVGF QTNLKWGEQR RVFSMIPGLE
310 320 330 340 350
QAEFVRYGVM HRNTYINAPV LLSPNLMLKS RPGLFIAGQL SGVEGYVESA
360 370 380 390 400
AAGLVAGLNA ARLYKGLEPL VFPPETAHGA LINYIVTADP ANFQPMNVNF
410 420 430
GLFPPLPGKR VRRRPERNLA HAQRALERLA AWLTEKGEG
Length:439
Mass (Da):48,337
Last modified:April 29, 2008 - v1
Checksum:iC6BFC35D04A980B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000860 Genomic DNA Translation: ACA59135.1
RefSeqiWP_012301723.1, NC_010424.1

Genome annotation databases

EnsemblBacteriaiACA59135; ACA59135; Daud_0601
KEGGidau:Daud_0601

Similar proteinsi

Entry informationi

Entry nameiTRMFO_DESAP
AccessioniPrimary (citable) accession number: B1I258
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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