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B1I1S3 (THIM_DESAP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Daud_0479
OrganismDesulforudis audaxviator (strain MP104C) [Complete proteome] [HAMAP]
Taxonomic identifier477974 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeCandidatus Desulforudis

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383852

Sites

Binding site491Substrate; via amide nitrogen By similarity
Binding site1251ATP By similarity
Binding site1711ATP By similarity
Binding site1981Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B1I1S3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 08DE567978D5F95D

FASTA27328,219
        10         20         30         40         50         60 
MNVSELRLRF ANALARIRAT KPLVHHITNY VVMNDTANVT LHVGALPVMA HTTEEAAEMT 

        70         80         90        100        110        120 
GLAGALVLNI GTLSPAWVDA MLLAGRRANE SGIPVVLDPV GAGATAYRTE TCLRLLGGLR 

       130        140        150        160        170        180 
VAVIRGNSGE IGTLSGAGGV VRGVESVEGV ANPAAAAGVL AHRYNTVTVI TGQRDIVTDG 

       190        200        210        220        230        240 
GRVLVVDNGH EWLTTITGSG CMATALVAAF AAVEPDFLVA AAGALAAYGL AAELAAREAR 

       250        260        270 
GPASFRTALL DRIYSLTPEQ VAEGARVERL RQP 

« Hide

References

[1]"Complete sequence of chromosome of Desulforudis audaxviator MP104C."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MP104C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000860 Genomic DNA. Translation: ACA59025.1.
RefSeqYP_001716657.1. NC_010424.1.

3D structure databases

ProteinModelPortalB1I1S3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING477974.Daud_0479.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA59025; ACA59025; Daud_0479.
GeneID6026519.
KEGGdau:Daud_0479.
PATRIC31967713. VBICanDes92303_0505.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMATISESTY.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycDAUD477974:GH0B-495-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_DESAP
AccessionPrimary (citable) accession number: B1I1S3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 29, 2008
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways