B1I1P5 (B1I1P5_DESAP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase 1 HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase 1 HAMAP MF_01543

Gene names

Name:	fhs1 HAMAP MF_01543
Ordered Locus Names:	Daud_0089

Organism

Desulforudis audaxviator (strain MP104C) [Complete proteome] [HAMAP] EMBL ACA58657.1

Taxonomic identifier

477974 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Candidatus Desulforudis

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543
Ligand	ATP-binding HAMAP MF_01543 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 EMBL ACA58657.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	67 – 74	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B1I1P5 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 4FAE31BC2738EA96	FASTA	566	60,836
	10 20 30 40 50 60 MTFRTDLEIA QAHQMIPITD LAASIGLSEE DIDLYGRYKA KIGLHVLEKF KERPAGRLID 70 80 90 100 110 120 VTAVTPTPLG EGKTLTTIGL TQGLGRIGKR AACTLRQPSM GPVFGIKGGA AGGGYAQVVP 130 140 150 160 170 180 MEDLNLHFTG DIHAVGQAHN LLAAMLDASL YHGNPHDIDL HTITWTRVMD VNDRALRDVV 190 200 210 220 230 240 VGLGGPVNGY PREAAFEATT ASEVMAVLAL ADGIQNLRQR LGRIVVGFNR KGHPVTAEDL 250 260 270 280 290 300 QGAGAMAVIL KEAVKPNLIQ TLEGQPCIVH AGPFANIAHG QCSVLADRMA LKLVDYVVTE 310 320 330 340 350 360 SGFGADLGME KFMDIKCRQS GLRPDCVVVT CTIRSLKMHG GVGRIIPGKP LPEEIRRENP 370 380 390 400 410 420 AAVAEGCRNL AHMIKIAHYY GVPVVVAVNR FLEDTDAEVE TVLREAVRAG ALSAHPVTAW 430 440 450 460 470 480 AEGGAGAVDL AAGVVSACER GGEFRLLYPD ELSIKEKIEV LARRVYNADE VAYEPLAEKK 490 500 510 520 530 540 IARFEELGWG RLPICMAKTH LSISHDPMLR NVPSGYVFPI RDIRVSLGAG FLYPLAGAML 550 560 TMPGLPSRPA AFGIDIDERG RVKGLF

References

[1]

"Complete sequence of chromosome of Desulforudis audaxviator MP104C." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L., Hauser L., Kyrpides N., Ivanova N.N., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000860 Genomic DNA. Translation: ACA58657.1.
RefSeq	YP_001716289.1. NC_010424.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B1I1P5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6027036.
GenomeReviews	Gene locus Daud_0089 in contig CP000860_GR.
KEGG	dau:Daud_0089.
PATRIC	31966875. VBICanDes92303_0094.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	NHLHHGN.
ProtClustDB	CLSK2323174.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1I1P5_DESAP

Accession

Primary (citable) accession number: B1I1P5

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)