B1HXF0 (B1HXF0_LYSSC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
1-pyrroline-5-carboxylate dehydrogenase HAMAP MF_00733
Short name=P5C dehydrogenase HAMAP MF_00733
EC=1.5.1.12 HAMAP MF_00733

Gene names

Name:	rocA HAMAP MF_00733
Ordered Locus Names:	Bsph_0622

Organism

Lysinibacillus sphaericus (strain C3-41) [Complete proteome] [HAMAP] EMBL ACA38245.1

Taxonomic identifier

444177 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Lysinibacillus

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP MF_00733
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP MF_00733
Sequence similarities	Belongs to the aldehyde dehydrogenase family. RocA subfamily. HAMAP MF_00733

Ontologies

Keywords
Ligand	NAD HAMAP MF_00733
Molecular function	Oxidoreductase HAMAP MF_00733 EMBL ACA38245.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	1-pyrroline-5-carboxylate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	285	1	By similarity HAMAP MF_00733
	Active site	319	1	By similarity HAMAP MF_00733

Sequences

	Sequence		Length	Mass (Da)
	B1HXF0 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: ECD03B1E7FC3187F	FASTA	514	56,166
	10 20 30 40 50 60 MIPYKHEPFT DFSQEANYNA YVEALNKVEG YLGQDYPLII GGERITTEDK IVSYNPAKKT 70 80 90 100 110 120 EVIGRVSKAS KDLAEKAMQA ADETFKTWKK VDPAIRADVL FKAAAIIRRR KHEFSALLTK 130 140 150 160 170 180 EAGKPWAEAD ADTAEAIDFL EYYGRQMLRI KNGQPVESRP GEYNRYDYIP LGIGIVISPW 190 200 210 220 230 240 NFPFAIMAGT TVAALVTGNT VLLKPASTTP VVAYKFIEVL EEAGLPAGAV NFVPGSGAEV 250 260 270 280 290 300 GDYLVDHPKT RFISFTGSRD VGLRINQRAS VLNDGQIWIK RVIAEMGGKD TIVVDKEADL 310 320 330 340 350 360 ELAAQSIVKS AFGFSGQKCS ACSRAVIVED VYDQVVNRVE ELTNALTVGD PTDFSNFMAT 370 380 390 400 410 420 VIDQAAFNKI TEYIEIGKGE GRLVAGGTAD DSVGYFVQPT VFADVEPSAR IMKEEIFGPV 430 440 450 460 470 480 VAIAKAKDFD HAIEIANDTE YGLTGAVITT NRMNLEKARE EFHVGNLYFN RGCTGAIVGY 490 500 510 QPFGGFNMSG TDSKAGGPDY LQLHMQAKTT SEML

References

[1]

"Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species." Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z. J. Bacteriol. 190:2892-2902(2008) [PubMed: 18296527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000817 Genomic DNA. Translation: ACA38245.1.
RefSeq	YP_001696375.1. NC_010382.1.
3D structure databases
ProteinModelPortal	B1HXF0.
SMR	B1HXF0. Positions 2-512.
ModBase	Search...
Protein-protein interaction databases
STRING	B1HXF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6020608.
GenomeReviews	Gene locus Bsph_0622 in contig CP000817_GR.
KEGG	lsp:Bsph_0622.
PATRIC	22413726. VBILysSph89750_0760.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG752218.
OMA	TPYKHEP.
ProtClustDB	PRK03137.
Family and domain databases
HAMAP	MF_00733. RocA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR005932. Delta1-pyrroline-5-COlate_DH-2. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00294.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01237. D1pyr5carbox2. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1HXF0_LYSSC

Accession

Primary (citable) accession number: B1HXF0

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)