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Protein

Isocitrate dehydrogenase [NADP]

Gene

Bsph_4121

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciLSPH444177:GJEL-4094-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Bsph_4121Imported
OrganismiLysinibacillus sphaericus (strain C3-41)Imported
Taxonomic identifieri444177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
ProteomesiUP000002164 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi444177.Bsph_4121.

Structurei

3D structure databases

ProteinModelPortaliB1HX11.
SMRiB1HX11. Positions 13-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1HX11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMNLGGNRM SNKIVVENGV LNVPNNPVIP FIEGDGIGPD IWAAASRVID
60 70 80 90 100
AAVEKAYNGE KKIEWLEVLA GEKAFNQTGE WLPQETLDKI NEYLIAIKGP
110 120 130 140 150
LTTPIGGGIR SLNVALRQQL DLYVCLRPVR HFDGVPSPVK RPEDVDMVIF
160 170 180 190 200
RENTEDIYAG IEFESGSEQA QKIINFLQSE FGVNQIRFPE TSGIGVKPVS
210 220 230 240 250
KEGTERLVRS AIEYAIKHKR PSVTLVHKGN IMKFTEGGFK KWGYELAEKE
260 270 280 290 300
FADQTFTWNQ YDAIKAEQGE EAANKAQSDA LAAGKILVKD SIADIFLQQI
310 320 330 340 350
LTRPTEFDVV ATMNLNGDYI SDALAAQVGG IGIAPGANIN YVTGHAIFEA
360 370 380 390 400
THGTAPKYAG LDKVNPSSVL LSGVLMLEHL GWQEAADMIT KSVEQTISSK
410 420
VVTYDFARLM DGATEVKCSE FANELIKNL
Length:429
Mass (Da):47,020
Last modified:April 29, 2008 - v1
Checksum:i6EBA6A1B4CA1BBE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000817 Genomic DNA. Translation: ACA41587.1.

Genome annotation databases

EnsemblBacteriaiACA41587; ACA41587; Bsph_4121.
KEGGilsp:Bsph_4121.
PATRICi22420685. VBILysSph89750_4199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000817 Genomic DNA. Translation: ACA41587.1.

3D structure databases

ProteinModelPortaliB1HX11.
SMRiB1HX11. Positions 13-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi444177.Bsph_4121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA41587; ACA41587; Bsph_4121.
KEGGilsp:Bsph_4121.
PATRICi22420685. VBILysSph89750_4199.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciLSPH444177:GJEL-4094-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
    Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
    J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C3-41Imported.

Entry informationi

Entry nameiB1HX11_LYSSC
AccessioniPrimary (citable) accession number: B1HX11
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 22, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.