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B1HX11

- B1HX11_LYSSC

UniProt

B1HX11 - B1HX11_LYSSC

Protein

Isocitrate dehydrogenase [NADP]

Gene

Bsph_4121

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciLSPH444177:GJEL-4094-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Bsph_4121Imported
    OrganismiLysinibacillus sphaericus (strain C3-41)Imported
    Taxonomic identifieri444177 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
    ProteomesiUP000002164: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi444177.Bsph_4121.

    Structurei

    3D structure databases

    ProteinModelPortaliB1HX11.
    SMRiB1HX11. Positions 13-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1HX11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMNLGGNRM SNKIVVENGV LNVPNNPVIP FIEGDGIGPD IWAAASRVID    50
    AAVEKAYNGE KKIEWLEVLA GEKAFNQTGE WLPQETLDKI NEYLIAIKGP 100
    LTTPIGGGIR SLNVALRQQL DLYVCLRPVR HFDGVPSPVK RPEDVDMVIF 150
    RENTEDIYAG IEFESGSEQA QKIINFLQSE FGVNQIRFPE TSGIGVKPVS 200
    KEGTERLVRS AIEYAIKHKR PSVTLVHKGN IMKFTEGGFK KWGYELAEKE 250
    FADQTFTWNQ YDAIKAEQGE EAANKAQSDA LAAGKILVKD SIADIFLQQI 300
    LTRPTEFDVV ATMNLNGDYI SDALAAQVGG IGIAPGANIN YVTGHAIFEA 350
    THGTAPKYAG LDKVNPSSVL LSGVLMLEHL GWQEAADMIT KSVEQTISSK 400
    VVTYDFARLM DGATEVKCSE FANELIKNL 429
    Length:429
    Mass (Da):47,020
    Last modified:April 29, 2008 - v1
    Checksum:i6EBA6A1B4CA1BBE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000817 Genomic DNA. Translation: ACA41587.1.
    RefSeqiWP_012295619.1. NC_010382.1.
    YP_001699717.1. NC_010382.1.

    Genome annotation databases

    EnsemblBacteriaiACA41587; ACA41587; Bsph_4121.
    GeneIDi6022806.
    KEGGilsp:Bsph_4121.
    PATRICi22420685. VBILysSph89750_4199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000817 Genomic DNA. Translation: ACA41587.1 .
    RefSeqi WP_012295619.1. NC_010382.1.
    YP_001699717.1. NC_010382.1.

    3D structure databases

    ProteinModelPortali B1HX11.
    SMRi B1HX11. Positions 13-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444177.Bsph_4121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA41587 ; ACA41587 ; Bsph_4121 .
    GeneIDi 6022806.
    KEGGi lsp:Bsph_4121.
    PATRICi 22420685. VBILysSph89750_4199.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci LSPH444177:GJEL-4094-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
      Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
      J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C3-41Imported.

    Entry informationi

    Entry nameiB1HX11_LYSSC
    AccessioniPrimary (citable) accession number: B1HX11
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3