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B1HW75 (B1HW75_LYSSC) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405
Gene names
Ordered Locus Names:Bsph_4046
OrganismLysinibacillus sphaericus (strain C3-41) [Complete proteome] [HAMAP] EMBL ACA41514.1
Taxonomic identifier444177 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Lysinibacillus

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405 SAAS SAAS020922

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405 SAAS SAAS020922

Subunit structure

Homodimer By similarity. HAMAP MF_01405 SAAS SAAS020922

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP MF_01405

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region8 – 136Substrate binding By similarity HAMAP MF_01405
Region70 – 712Substrate binding By similarity HAMAP MF_01405

Sites

Metal binding411Magnesium or manganese By similarity HAMAP MF_01405
Metal binding701Magnesium or manganese By similarity HAMAP MF_01405
Binding site1551Substrate By similarity HAMAP MF_01405
Binding site1751Substrate By similarity HAMAP MF_01405
Binding site1811Substrate By similarity HAMAP MF_01405

Sequences

Sequence LengthMass (Da)Tools
B1HW75 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 0439A0F9696D1A54

FASTA19721,436
        10         20         30         40         50         60 
MKQVVIATKN KGKAKDFEAL FGPLGYEVVT MFEVAPDMEI EETGTTFEEN AILKAEALAK 

        70         80         90        100        110        120 
NLGTIVIADD SGLAVDALNG EPGVYSARYA GDHDDEANMV KLLENLQGVE DDKRTARFCC 

       130        140        150        160        170        180 
CIAIAGPDFN TTTVFGTCEG VIAHEKRGTN GFGYDPIFFV PSLNRMMAEL TPEEKGAISH 

       190 
RGNAIRKLKE QLPNLMK

« Hide

References

[1]"Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
J. Bacteriol. 190:2892-2902(2008) [PubMed: 18296527] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000817 Genomic DNA. Translation: ACA41514.1.
RefSeqYP_001699644.1. NC_010382.1.

3D structure databases

ProteinModelPortalB1HW75.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1HW75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6023034.
GenomeReviewsGene locus Bsph_4046 in contig CP000817_GR.
KEGGlsp:Bsph_4046.
PATRIC22420531. VBILysSph89750_4122.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697237.
OMAYSKRYDQ.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1HW75_LYSSC
AccessionPrimary (citable) accession number: B1HW75
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info