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B1HUY7

- PCP_LYSSC

UniProt

B1HUY7 - PCP_LYSSC

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Protein
Pyrrolidone-carboxylate peptidase
Gene
pcp, Bsph_2127
Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801 By similarity
Active sitei142 – 1421 By similarity
Active sitei165 – 1651 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciLSPH444177:GJEL-2154-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Short name:
    Pyrase
    Gene namesi
    Name:pcp
    Ordered Locus Names:Bsph_2127
    OrganismiLysinibacillus sphaericus (strain C3-41)
    Taxonomic identifieri444177 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
    ProteomesiUP000002164: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Pyrrolidone-carboxylate peptidaseUniRule annotation
    PRO_1000124000Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi444177.Bsph_2127.

    Structurei

    3D structure databases

    ProteinModelPortaliB1HUY7.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiERIAINC.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1HUY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKILLTGFE PFLDYKLNPT MQIVENLDGE KIENYHIIGR ILSVDFQQSA    50
    EQLKRHIEEI EPQIIISLGL AGGRFKITPE RIAINIKDGE PDNNGYSPVD 100
    ESIQEEGADA YLTNLPIRHM INRLQEEGYP AEISNTAGTY LCNNIMYEGL 150
    VYAQQHEGVR AGFIHIPASF ELAIQHGKIP GWHIRDLIAA VKLCIEETVR 200
    AGNH 204
    Length:204
    Mass (Da):22,962
    Last modified:April 29, 2008 - v1
    Checksum:i8061BF5FB277BA7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000817 Genomic DNA. Translation: ACA39698.1.
    RefSeqiWP_012293787.1. NC_010382.1.
    YP_001697828.1. NC_010382.1.

    Genome annotation databases

    EnsemblBacteriaiACA39698; ACA39698; Bsph_2127.
    GeneIDi6022816.
    KEGGilsp:Bsph_2127.
    PATRICi22416761. VBILysSph89750_2245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000817 Genomic DNA. Translation: ACA39698.1 .
    RefSeqi WP_012293787.1. NC_010382.1.
    YP_001697828.1. NC_010382.1.

    3D structure databases

    ProteinModelPortali B1HUY7.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 444177.Bsph_2127.

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA39698 ; ACA39698 ; Bsph_2127 .
    GeneIDi 6022816.
    KEGGi lsp:Bsph_2127.
    PATRICi 22416761. VBILysSph89750_2245.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi ERIAINC.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci LSPH444177:GJEL-2154-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
      Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
      J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C3-41.

    Entry informationi

    Entry nameiPCP_LYSSC
    AccessioniPrimary (citable) accession number: B1HUY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: September 3, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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