ID   B1HU87_LYSSC            Unreviewed;       584 AA.
AC   B1HU87;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 105.
DE   SubName: Full=Multidrug resistance ABC transporter ATP-binding and permease protein {ECO:0000313|EMBL:ACA39642.1};
DE            EC=3.6.3.44 {ECO:0000313|EMBL:ACA39642.1};
GN   OrderedLocusNames=Bsph_2065 {ECO:0000313|EMBL:ACA39642.1};
OS   Lysinibacillus sphaericus (strain C3-41).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=444177 {ECO:0000313|EMBL:ACA39642.1, ECO:0000313|Proteomes:UP000002164};
RN   [1] {ECO:0000313|EMBL:ACA39642.1, ECO:0000313|Proteomes:UP000002164}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3-41 {ECO:0000313|EMBL:ACA39642.1,
RC   ECO:0000313|Proteomes:UP000002164};
RX   PubMed=18296527; DOI=10.1128/JB.01652-07;
RA   Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M.,
RA   Berry C., Yuan Z.;
RT   "Complete genome sequence of the mosquitocidal bacterium Bacillus
RT   sphaericus C3-41 and comparison with those of closely related Bacillus
RT   species.";
RL   J. Bacteriol. 190:2892-2902(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP000817; ACA39642.1; -; Genomic_DNA.
DR   RefSeq; WP_012293733.1; NC_010382.1.
DR   AlphaFoldDB; B1HU87; -.
DR   EnsemblBacteria; ACA39642; ACA39642; Bsph_2065.
DR   KEGG; lsp:Bsph_2065; -.
DR   HOGENOM; CLU_000604_84_3_9; -.
DR   Proteomes; UP000002164; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd18551; ABC_6TM_LmrA_like; 1.
DR   Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR   PANTHER; PTHR24221:SF524; MULTIDRUG RESISTANCE ABC TRANSPORTER ATP-BINDING_PERMEASE PROTEIN BMRA; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:ACA39642.1};
KW   Hydrolase {ECO:0000313|EMBL:ACA39642.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        66..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        251..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..311
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50929"
FT   DOMAIN          343..577
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   584 AA;  65303 MW;  132EDE0D6EF5AA82 CRC64;
     MQETSKETTK KPDWRRFIQL VKRAEPPIWL LVIALIMSLA TTGVGFIVPL FTKQLVDGFS
     LESLNYWQII LLGIAFIAQA IASGLSIYYL NRVGHHVVAK LRDQLWRKLL HLPIPYYDEN
     DTGETLSRVT NDTAVVKELI TEHLANCLSG VISIIGSIII LLFLDWKMTL VMLIAVPLAM
     VILMLLGKRM FVISKGMQDE TAKFTSVLNQ VLPETRLVKA SNAEQVEYER GKKGITNLFN
     FGLKEAKIHA LISPLISFVL MSVLVAIIGY GGVRVSSGEL TAGDMVAFIL YLIQIIMPMT
     QLTMFFTQLQ KAMGATERIS ALLEHEEEHI EEGITVNKID QPIYVNNVDF SYGEDPILSN
     ITFTIEPGKV TAIVGPSGGG KTTTFSLLER YYQPTSGTIT LGKTPIETFS LHSWRSQIGY
     VAQESALLSG TIRENICYGV DREVQDDELE RVAKMAYADQ FINDLPDKFD TEVGERGIKL
     SGGQRQRISI ARALLRNPQI LMLDEATSSL DSKSEIYVQK ALDNLMQGRT TLVIAHRLST
     VVDADQILFV EKGQITGCGT HETLFETHAM YREFAMQQLR IKEN
//