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B1HTV6

- PUR5_LYSSC

UniProt

B1HTV6 - PUR5_LYSSC

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSPH444177:GJEL-230-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Bsph_0216
OrganismiLysinibacillus sphaericus (strain C3-41)
Taxonomic identifieri444177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
ProteomesiUP000002164: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000193031Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444177.Bsph_0216.

Structurei

3D structure databases

ProteinModelPortaliB1HTV6.
SMRiB1HTV6. Positions 13-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B1HTV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKAYEQAGV NIEAGYEAVK RMKSHVERTN RLGVMGTFGG FGGMFDLSEL
60 70 80 90 100
NLKEPVLISG TDGVGTKLKL AFMVDKHDTI GVDCVAMCVN DIVAQGAEPL
110 120 130 140 150
YFLDYVALGK AEPAKIEQIV KGVADGCVQS GAALIGGETA EMPGLYEEDE
160 170 180 190 200
YDLAGFAVGA CEKSAIVTGE RIVEGDVLIG IASSGVHSNG YSLVRKIVFA
210 220 230 240 250
DRQYAVDAIV ENYEDLGPIG EALLVPTKLY AKPVLAALKA ADVHGCAHVT
260 270 280 290 300
GGGFYENLPR MMPEGLATEI DLGSWPVLRI FEFLKDKGQL EDKDLYNVFN
310 320 330 340 350
MGIGFVIAAP AAEADKVMAA VEANGEKAYT IGRVIKGNGV VFNGTHDGSL

V
Length:351
Mass (Da):37,181
Last modified:April 29, 2008 - v1
Checksum:i9083A79BF3DF6AF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000817 Genomic DNA. Translation: ACA37847.1.
RefSeqiWP_012292016.1. NC_010382.1.
YP_001695977.1. NC_010382.1.

Genome annotation databases

EnsemblBacteriaiACA37847; ACA37847; Bsph_0216.
GeneIDi6021864.
KEGGilsp:Bsph_0216.
PATRICi22412888. VBILysSph89750_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000817 Genomic DNA. Translation: ACA37847.1 .
RefSeqi WP_012292016.1. NC_010382.1.
YP_001695977.1. NC_010382.1.

3D structure databases

ProteinModelPortali B1HTV6.
SMRi B1HTV6. Positions 13-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444177.Bsph_0216.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA37847 ; ACA37847 ; Bsph_0216 .
GeneIDi 6021864.
KEGGi lsp:Bsph_0216.
PATRICi 22412888. VBILysSph89750_0363.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LSPH444177:GJEL-230-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
    Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
    J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C3-41.

Entry informationi

Entry nameiPUR5_LYSSC
AccessioniPrimary (citable) accession number: B1HTV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3