B1HTK8 (DEOC_LYSSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	Bsph_3728

Organism

Lysinibacillus sphaericus (strain C3-41) [Complete proteome] [HAMAP]

Taxonomic identifier

444177 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Lysinibacillus

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000094849
Sites
	Active site	154	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	183	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1HTK8 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 37116E57DBEBA75A	FASTA	223	23,256
	10 20 30 40 50 60 MEQNFARMID HTLLKAEATK EQIEKLCAEA KQFNFASVCV NPTWVKHSSE LLQGSDVLVC 70 80 90 100 110 120 TVIGFPLGAN TPAVKAFEVK DAIANGANEV DMVINIGALK DKNYDLVQAD IAAVVQAAKG 130 140 150 160 170 180 SALVKVIIES CLLTDEEKVK ACELAVAAGA DYVKTSTGFS TGGATAADIA LMRKTVGPEL 190 200 210 220 GVKASGGVRS LEDMKSMVEA GATRIGASSG VAIMNGLIAD SNY

References

[1]

"Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species." Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z. J. Bacteriol. 190:2892-2902(2008) [PubMed: 18296527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C3-41.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000817 Genomic DNA. Translation: ACA41212.1.
RefSeq	YP_001699342.1. NC_010382.1.
3D structure databases
ProteinModelPortal	B1HTK8.
SMR	B1HTK8. Positions 3-219.
ModBase	Search...
Protein-protein interaction databases
STRING	B1HTK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6022994.
GenomeReviews	Gene locus Bsph_3728 in contig CP000817_GR.
KEGG	lsp:Bsph_3728.
PATRIC	22419895. VBILysSph89750_3805.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG636421.
OMA	CLEAREN.
Enzyme and pathway databases
BioCyc	LSPH444177:BSPH_3728-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_LYSSC

Accession

Primary (citable) accession number: B1HTK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program