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B1HSN6 (GCSPA_LYSSC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Bsph_3608
OrganismLysinibacillus sphaericus (strain C3-41) [Complete proteome] [HAMAP]
Taxonomic identifier444177 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132483

Sequences

Sequence LengthMass (Da)Tools
B1HSN6 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 0B8F2660CE65A851

FASTA44848,697
        10         20         30         40         50         60 
MKHRYLPMTE QDQKEMLDVI GVSSVDELFE DIPEKVRFKG LYDIKAAKSE SALLKELTAL 

        70         80         90        100        110        120 
AAKNKDTNAN VSFLGAGVYN HYKPVIVDHV ISRSEFYTAY TPYQPEISQG ELQAIFEFQT 

       130        140        150        160        170        180 
MIAELTGMDL ANSSMYDGGT ALAEAGMLAA GHTRRKKILV SETVHPEYRD VVATYAYGQS 

       190        200        210        220        230        240 
IEIVTIPHKD GVTDIAALKE LIDDNTAAVI AQYPNFFGQV EDIQVIGDIA HEAKSLFVVS 

       250        260        270        280        290        300 
SNPLALGILT PPGKLGADIC VGDAQVFGIS EAFGGPHCGF FAVTTKLMRK VPGRLVGETV 

       310        320        330        340        350        360 
DGEGRRGYVL TLQAREQHIR RDKATSNICS NQALLALAAS VAMTALGKQG IREMATQNIA 

       370        380        390        400        410        420 
KTRYAKNAFE AAGFTVAFQG AHFNEIVVKT NKCVKEINKG LIEKGIIGGY PLGQNYDSLK 

       430        440 
HHVLIAVTEL RTKEEIDALV AEMGALHA 

« Hide

References

[1]"Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C3-41.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000817 Genomic DNA. Translation: ACA41094.1.
RefSeqYP_001699224.1. NC_010382.1.

3D structure databases

ProteinModelPortalB1HSN6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING444177.Bsph_3608.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA41094; ACA41094; Bsph_3608.
GeneID6023668.
KEGGlsp:Bsph_3608.
PATRIC22419653. VBILysSph89750_3684.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycLSPH444177:GJEL-3590-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_LYSSC
AccessionPrimary (citable) accession number: B1HSN6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families