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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Bsph_3608
OrganismiLysinibacillus sphaericus (strain C3-41)
Taxonomic identifieri444177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324831 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PRIDEiB1HSN6

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi444177.Bsph_3608

Structurei

3D structure databases

ProteinModelPortaliB1HSN6
SMRiB1HSN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B1HSN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHRYLPMTE QDQKEMLDVI GVSSVDELFE DIPEKVRFKG LYDIKAAKSE
60 70 80 90 100
SALLKELTAL AAKNKDTNAN VSFLGAGVYN HYKPVIVDHV ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MIAELTGMDL ANSSMYDGGT ALAEAGMLAA
160 170 180 190 200
GHTRRKKILV SETVHPEYRD VVATYAYGQS IEIVTIPHKD GVTDIAALKE
210 220 230 240 250
LIDDNTAAVI AQYPNFFGQV EDIQVIGDIA HEAKSLFVVS SNPLALGILT
260 270 280 290 300
PPGKLGADIC VGDAQVFGIS EAFGGPHCGF FAVTTKLMRK VPGRLVGETV
310 320 330 340 350
DGEGRRGYVL TLQAREQHIR RDKATSNICS NQALLALAAS VAMTALGKQG
360 370 380 390 400
IREMATQNIA KTRYAKNAFE AAGFTVAFQG AHFNEIVVKT NKCVKEINKG
410 420 430 440
LIEKGIIGGY PLGQNYDSLK HHVLIAVTEL RTKEEIDALV AEMGALHA
Length:448
Mass (Da):48,697
Last modified:April 29, 2008 - v1
Checksum:i0B8F2660CE65A851
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000817 Genomic DNA Translation: ACA41094.1

Genome annotation databases

EnsemblBacteriaiACA41094; ACA41094; Bsph_3608
KEGGilsp:Bsph_3608

Entry informationi

Entry nameiGCSPA_LYSSC
AccessioniPrimary (citable) accession number: B1HSN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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