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B1HSN6

- GCSPA_LYSSC

UniProt

B1HSN6 - GCSPA_LYSSC

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Bsph_3608
Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciLSPH444177:GJEL-3590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Bsph_3608
OrganismiLysinibacillus sphaericus (strain C3-41)
Taxonomic identifieri444177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
ProteomesiUP000002164: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000132483Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi444177.Bsph_3608.

Structurei

3D structure databases

ProteinModelPortaliB1HSN6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B1HSN6-1 [UniParc]FASTAAdd to Basket

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MKHRYLPMTE QDQKEMLDVI GVSSVDELFE DIPEKVRFKG LYDIKAAKSE    50
SALLKELTAL AAKNKDTNAN VSFLGAGVYN HYKPVIVDHV ISRSEFYTAY 100
TPYQPEISQG ELQAIFEFQT MIAELTGMDL ANSSMYDGGT ALAEAGMLAA 150
GHTRRKKILV SETVHPEYRD VVATYAYGQS IEIVTIPHKD GVTDIAALKE 200
LIDDNTAAVI AQYPNFFGQV EDIQVIGDIA HEAKSLFVVS SNPLALGILT 250
PPGKLGADIC VGDAQVFGIS EAFGGPHCGF FAVTTKLMRK VPGRLVGETV 300
DGEGRRGYVL TLQAREQHIR RDKATSNICS NQALLALAAS VAMTALGKQG 350
IREMATQNIA KTRYAKNAFE AAGFTVAFQG AHFNEIVVKT NKCVKEINKG 400
LIEKGIIGGY PLGQNYDSLK HHVLIAVTEL RTKEEIDALV AEMGALHA 448
Length:448
Mass (Da):48,697
Last modified:April 29, 2008 - v1
Checksum:i0B8F2660CE65A851
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000817 Genomic DNA. Translation: ACA41094.1.
RefSeqiWP_012295153.1. NC_010382.1.
YP_001699224.1. NC_010382.1.

Genome annotation databases

EnsemblBacteriaiACA41094; ACA41094; Bsph_3608.
GeneIDi6023668.
KEGGilsp:Bsph_3608.
PATRICi22419653. VBILysSph89750_3684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000817 Genomic DNA. Translation: ACA41094.1 .
RefSeqi WP_012295153.1. NC_010382.1.
YP_001699224.1. NC_010382.1.

3D structure databases

ProteinModelPortali B1HSN6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444177.Bsph_3608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA41094 ; ACA41094 ; Bsph_3608 .
GeneIDi 6023668.
KEGGi lsp:Bsph_3608.
PATRICi 22419653. VBILysSph89750_3684.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci LSPH444177:GJEL-3590-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
    Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
    J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C3-41.

Entry informationi

Entry nameiGCSPA_LYSSC
AccessioniPrimary (citable) accession number: B1HSN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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