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B1HSN6

- GCSPA_LYSSC

UniProt

B1HSN6 - GCSPA_LYSSC

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciLSPH444177:GJEL-3590-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Bsph_3608
    OrganismiLysinibacillus sphaericus (strain C3-41)
    Taxonomic identifieri444177 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
    ProteomesiUP000002164: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132483Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi444177.Bsph_3608.

    Structurei

    3D structure databases

    ProteinModelPortaliB1HSN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1HSN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKHRYLPMTE QDQKEMLDVI GVSSVDELFE DIPEKVRFKG LYDIKAAKSE    50
    SALLKELTAL AAKNKDTNAN VSFLGAGVYN HYKPVIVDHV ISRSEFYTAY 100
    TPYQPEISQG ELQAIFEFQT MIAELTGMDL ANSSMYDGGT ALAEAGMLAA 150
    GHTRRKKILV SETVHPEYRD VVATYAYGQS IEIVTIPHKD GVTDIAALKE 200
    LIDDNTAAVI AQYPNFFGQV EDIQVIGDIA HEAKSLFVVS SNPLALGILT 250
    PPGKLGADIC VGDAQVFGIS EAFGGPHCGF FAVTTKLMRK VPGRLVGETV 300
    DGEGRRGYVL TLQAREQHIR RDKATSNICS NQALLALAAS VAMTALGKQG 350
    IREMATQNIA KTRYAKNAFE AAGFTVAFQG AHFNEIVVKT NKCVKEINKG 400
    LIEKGIIGGY PLGQNYDSLK HHVLIAVTEL RTKEEIDALV AEMGALHA 448
    Length:448
    Mass (Da):48,697
    Last modified:April 29, 2008 - v1
    Checksum:i0B8F2660CE65A851
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000817 Genomic DNA. Translation: ACA41094.1.
    RefSeqiWP_012295153.1. NC_010382.1.
    YP_001699224.1. NC_010382.1.

    Genome annotation databases

    EnsemblBacteriaiACA41094; ACA41094; Bsph_3608.
    GeneIDi6023668.
    KEGGilsp:Bsph_3608.
    PATRICi22419653. VBILysSph89750_3684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000817 Genomic DNA. Translation: ACA41094.1 .
    RefSeqi WP_012295153.1. NC_010382.1.
    YP_001699224.1. NC_010382.1.

    3D structure databases

    ProteinModelPortali B1HSN6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444177.Bsph_3608.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA41094 ; ACA41094 ; Bsph_3608 .
    GeneIDi 6023668.
    KEGGi lsp:Bsph_3608.
    PATRICi 22419653. VBILysSph89750_3684.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci LSPH444177:GJEL-3590-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
      Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
      J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C3-41.

    Entry informationi

    Entry nameiGCSPA_LYSSC
    AccessioniPrimary (citable) accession number: B1HSN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3