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B1HSN5

- GCSPB_LYSSC

UniProt

B1HSN5 - GCSPB_LYSSC

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLSPH444177:GJEL-3589-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Bsph_3607
    OrganismiLysinibacillus sphaericus (strain C3-41)
    Taxonomic identifieri444177 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
    ProteomesiUP000002164: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132502Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi444177.Bsph_3607.

    Structurei

    3D structure databases

    ProteinModelPortaliB1HSN5.
    SMRiB1HSN5. Positions 5-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1HSN5-1 [UniParc]FASTAAdd to Basket

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    MHNENQTLIF EISKEGRVGY SLEALDVPEV DLADVLPANL VRSEAAELPE    50
    VSELDIMRHY TALSRRNHGV DSGFYPLGSC TMKYNPKINE AVARFSGFAN 100
    VHPLQDESTA QGAMELLYDL QTSLVEITGM DEVTLQPAAG AHGEWTALMM 150
    IRAFHEANGE GHRNKVIVPD SAHGTNPASA TVAGFETITV KSDDNGLVDI 200
    EDLRKVVGAD TAALMLTNPN TLGLFEENII EMAELIHSVG GKVYYDGANL 250
    NAVMSKARPG DMGFDCVHLN LHKTFTGPHG GGGPGSGPVG VKADLIPFLP 300
    KPVLVRTEEG AYHFDYNRPQ SIGRVKPYYG NFGINVRAYT YIRTMGPDGL 350
    KAVTEYAVLN ANYMMRRLEP FYDLPYNRHC KHEFVLSGHR QKKLGVRTLD 400
    IAKRLLDFGY HPPTTYFPLN VEEALMIEPT ETESKETLDA FCDVMIQIAK 450
    EAEENPSIVQ EAPHTTVVSR LDETRAARTP VLRYQKA 487
    Length:487
    Mass (Da):53,763
    Last modified:April 29, 2008 - v1
    Checksum:iEEB82ED3E299F179
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000817 Genomic DNA. Translation: ACA41093.1.
    RefSeqiWP_012295152.1. NC_010382.1.
    YP_001699223.1. NC_010382.1.

    Genome annotation databases

    EnsemblBacteriaiACA41093; ACA41093; Bsph_3607.
    GeneIDi6023667.
    KEGGilsp:Bsph_3607.
    PATRICi22419651. VBILysSph89750_3683.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000817 Genomic DNA. Translation: ACA41093.1 .
    RefSeqi WP_012295152.1. NC_010382.1.
    YP_001699223.1. NC_010382.1.

    3D structure databases

    ProteinModelPortali B1HSN5.
    SMRi B1HSN5. Positions 5-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444177.Bsph_3607.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA41093 ; ACA41093 ; Bsph_3607 .
    GeneIDi 6023667.
    KEGGi lsp:Bsph_3607.
    PATRICi 22419651. VBILysSph89750_3683.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci LSPH444177:GJEL-3589-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
      Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
      J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C3-41.

    Entry informationi

    Entry nameiGCSPB_LYSSC
    AccessioniPrimary (citable) accession number: B1HSN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3