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B1HSN5

- GCSPB_LYSSC

UniProt

B1HSN5 - GCSPB_LYSSC

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLSPH444177:GJEL-3589-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Bsph_3607
OrganismiLysinibacillus sphaericus (strain C3-41)
Taxonomic identifieri444177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
ProteomesiUP000002164: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi444177.Bsph_3607.

Structurei

3D structure databases

ProteinModelPortaliB1HSN5.
SMRiB1HSN5. Positions 5-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B1HSN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHNENQTLIF EISKEGRVGY SLEALDVPEV DLADVLPANL VRSEAAELPE
60 70 80 90 100
VSELDIMRHY TALSRRNHGV DSGFYPLGSC TMKYNPKINE AVARFSGFAN
110 120 130 140 150
VHPLQDESTA QGAMELLYDL QTSLVEITGM DEVTLQPAAG AHGEWTALMM
160 170 180 190 200
IRAFHEANGE GHRNKVIVPD SAHGTNPASA TVAGFETITV KSDDNGLVDI
210 220 230 240 250
EDLRKVVGAD TAALMLTNPN TLGLFEENII EMAELIHSVG GKVYYDGANL
260 270 280 290 300
NAVMSKARPG DMGFDCVHLN LHKTFTGPHG GGGPGSGPVG VKADLIPFLP
310 320 330 340 350
KPVLVRTEEG AYHFDYNRPQ SIGRVKPYYG NFGINVRAYT YIRTMGPDGL
360 370 380 390 400
KAVTEYAVLN ANYMMRRLEP FYDLPYNRHC KHEFVLSGHR QKKLGVRTLD
410 420 430 440 450
IAKRLLDFGY HPPTTYFPLN VEEALMIEPT ETESKETLDA FCDVMIQIAK
460 470 480
EAEENPSIVQ EAPHTTVVSR LDETRAARTP VLRYQKA
Length:487
Mass (Da):53,763
Last modified:April 29, 2008 - v1
Checksum:iEEB82ED3E299F179
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000817 Genomic DNA. Translation: ACA41093.1.
RefSeqiWP_012295152.1. NC_010382.1.
YP_001699223.1. NC_010382.1.

Genome annotation databases

EnsemblBacteriaiACA41093; ACA41093; Bsph_3607.
GeneIDi6023667.
KEGGilsp:Bsph_3607.
PATRICi22419651. VBILysSph89750_3683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000817 Genomic DNA. Translation: ACA41093.1 .
RefSeqi WP_012295152.1. NC_010382.1.
YP_001699223.1. NC_010382.1.

3D structure databases

ProteinModelPortali B1HSN5.
SMRi B1HSN5. Positions 5-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444177.Bsph_3607.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA41093 ; ACA41093 ; Bsph_3607 .
GeneIDi 6023667.
KEGGi lsp:Bsph_3607.
PATRICi 22419651. VBILysSph89750_3683.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci LSPH444177:GJEL-3589-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
    Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
    J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C3-41.

Entry informationi

Entry nameiGCSPB_LYSSC
AccessioniPrimary (citable) accession number: B1HSN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3