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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Bsph_3607
OrganismiLysinibacillus sphaericus (strain C3-41)
Taxonomic identifieri444177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
Proteomesi
  • UP000002164 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001325021 – 487Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi444177.Bsph_3607

Structurei

3D structure databases

ProteinModelPortaliB1HSN5
SMRiB1HSN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RGW Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B1HSN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNENQTLIF EISKEGRVGY SLEALDVPEV DLADVLPANL VRSEAAELPE
60 70 80 90 100
VSELDIMRHY TALSRRNHGV DSGFYPLGSC TMKYNPKINE AVARFSGFAN
110 120 130 140 150
VHPLQDESTA QGAMELLYDL QTSLVEITGM DEVTLQPAAG AHGEWTALMM
160 170 180 190 200
IRAFHEANGE GHRNKVIVPD SAHGTNPASA TVAGFETITV KSDDNGLVDI
210 220 230 240 250
EDLRKVVGAD TAALMLTNPN TLGLFEENII EMAELIHSVG GKVYYDGANL
260 270 280 290 300
NAVMSKARPG DMGFDCVHLN LHKTFTGPHG GGGPGSGPVG VKADLIPFLP
310 320 330 340 350
KPVLVRTEEG AYHFDYNRPQ SIGRVKPYYG NFGINVRAYT YIRTMGPDGL
360 370 380 390 400
KAVTEYAVLN ANYMMRRLEP FYDLPYNRHC KHEFVLSGHR QKKLGVRTLD
410 420 430 440 450
IAKRLLDFGY HPPTTYFPLN VEEALMIEPT ETESKETLDA FCDVMIQIAK
460 470 480
EAEENPSIVQ EAPHTTVVSR LDETRAARTP VLRYQKA
Length:487
Mass (Da):53,763
Last modified:April 29, 2008 - v1
Checksum:iEEB82ED3E299F179
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000817 Genomic DNA Translation: ACA41093.1

Genome annotation databases

EnsemblBacteriaiACA41093; ACA41093; Bsph_3607
KEGGilsp:Bsph_3607

Entry informationi

Entry nameiGCSPB_LYSSC
AccessioniPrimary (citable) accession number: B1HSN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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