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B1HR05

- IF2_LYSSC

UniProt

B1HR05 - IF2_LYSSC

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi268 – 2758GTPUniRule annotation
Nucleotide bindingi314 – 3185GTPUniRule annotation
Nucleotide bindingi368 – 3714GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSPH444177:GJEL-1639-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Bsph_1598
OrganismiLysinibacillus sphaericus (strain C3-41)
Taxonomic identifieri444177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
ProteomesiUP000002164: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Translation initiation factor IF-2PRO_1000093801Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444177.Bsph_1598.

Structurei

3D structure databases

ProteinModelPortaliB1HR05.
SMRiB1HR05. Positions 532-651, 660-757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 428170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 2758G1By similarity
Regioni293 – 2975G2By similarity
Regioni314 – 3174G3By similarity
Regioni368 – 3714G4By similarity
Regioni404 – 4063G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiIYKAIDD.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1HR05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKIRVHEYA KQVNKTSKEV IEALSKLNVS VTNHMSMLEK DIVSKLNQTF
60 70 80 90 100
KATPEKNVGK QATQNISQKS QSNGQQNHSV KKQEGQRQQS ATSKPKVNNQ
110 120 130 140 150
QHSNSSNEKS KNTKGNQNRN MTQNNNNNNN NNNNNRRGGG GYNQRPKPGI
160 170 180 190 200
HGGKRRHPKT HQPSIPVKQK ELPEKITFVE SLSVAELAKK LHREPSEIIK
210 220 230 240 250
KLFMLGVMAT INQELDKDAI ELICADYGVE VEEEIRVDIT DLETHFEQTE
260 270 280 290 300
EVNEAQLSER PPVVTIMGHV DHGKTTLLDS IRNTKVTAGE AGGITQHIGA
310 320 330 340 350
YQVTEGDKKI TFLDTPGHAA FTTMRARGAK VTDLTILVVA ADDGVMPQTV
360 370 380 390 400
EAINHAKAAE VPIIVAVNKM DKPSANPDRV MQELTEHGLV PEAWGGETIF
410 420 430 440 450
VPISALKGEG IDTLLEMILL VAEVGELKAN PDRLALGTVI EAQLDKGRGS
460 470 480 490 500
VATLLVQDGT LKVGDPIVVG HTFGRVRAMV NDKGRRVKEA GPSTPVEITG
510 520 530 540 550
LNDVPQAGDR FVVFEDEKTA RQVGETRAMS AIQAQRSEKQ RVTLDNLFEQ
560 570 580 590 600
MSQGEMKELN LIVKADVQGT VEAMAASLMK IDVEGVNVKI IHTGAGAITE
610 620 630 640 650
SDISLAAASN AIVIGFNVRP DVNAKRAAEE EGVDIRLHRI IYKVIEEIEQ
660 670 680 690 700
AMKGMLDPEF EEKIIGQAEV RQTIKVSKVG TIAGSYVTEG KVTRDSGVRV
710 720 730 740 750
IRDNVVIFEG ELDTLKRFKD EVKEVARGYE CGITITNFND IKEGDIIEAY

IMEEVKRV
Length:758
Mass (Da):83,264
Last modified:April 29, 2008 - v1
Checksum:i91E4CC40EF3546E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000817 Genomic DNA. Translation: ACA39196.1.
RefSeqiYP_001697326.1. NC_010382.1.

Genome annotation databases

EnsemblBacteriaiACA39196; ACA39196; Bsph_1598.
GeneIDi6021487.
KEGGilsp:Bsph_1598.
PATRICi22415693. VBILysSph89750_1713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000817 Genomic DNA. Translation: ACA39196.1 .
RefSeqi YP_001697326.1. NC_010382.1.

3D structure databases

ProteinModelPortali B1HR05.
SMRi B1HR05. Positions 532-651, 660-757.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444177.Bsph_1598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA39196 ; ACA39196 ; Bsph_1598 .
GeneIDi 6021487.
KEGGi lsp:Bsph_1598.
PATRICi 22415693. VBILysSph89750_1713.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi IYKAIDD.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci LSPH444177:GJEL-1639-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
    Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
    J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C3-41.

Entry informationi

Entry nameiIF2_LYSSC
AccessioniPrimary (citable) accession number: B1HR05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3