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B1HR05

- IF2_LYSSC

UniProt

B1HR05 - IF2_LYSSC

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Protein
Translation initiation factor IF-2
Gene
infB, Bsph_1598
Organism
Lysinibacillus sphaericus (strain C3-41)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi268 – 2758GTP By similarity
Nucleotide bindingi314 – 3185GTP By similarity
Nucleotide bindingi368 – 3714GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSPH444177:GJEL-1639-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:Bsph_1598
OrganismiLysinibacillus sphaericus (strain C3-41)
Taxonomic identifieri444177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus
ProteomesiUP000002164: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Translation initiation factor IF-2UniRule annotation
PRO_1000093801Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444177.Bsph_1598.

Structurei

3D structure databases

ProteinModelPortaliB1HR05.
SMRiB1HR05. Positions 532-651, 660-757.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 428170tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 2758G1 By similarity
Regioni293 – 2975G2 By similarity
Regioni314 – 3174G3 By similarity
Regioni368 – 3714G4 By similarity
Regioni404 – 4063G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiIYKAIDD.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1HR05-1 [UniParc]FASTAAdd to Basket

« Hide

MTKIRVHEYA KQVNKTSKEV IEALSKLNVS VTNHMSMLEK DIVSKLNQTF    50
KATPEKNVGK QATQNISQKS QSNGQQNHSV KKQEGQRQQS ATSKPKVNNQ 100
QHSNSSNEKS KNTKGNQNRN MTQNNNNNNN NNNNNRRGGG GYNQRPKPGI 150
HGGKRRHPKT HQPSIPVKQK ELPEKITFVE SLSVAELAKK LHREPSEIIK 200
KLFMLGVMAT INQELDKDAI ELICADYGVE VEEEIRVDIT DLETHFEQTE 250
EVNEAQLSER PPVVTIMGHV DHGKTTLLDS IRNTKVTAGE AGGITQHIGA 300
YQVTEGDKKI TFLDTPGHAA FTTMRARGAK VTDLTILVVA ADDGVMPQTV 350
EAINHAKAAE VPIIVAVNKM DKPSANPDRV MQELTEHGLV PEAWGGETIF 400
VPISALKGEG IDTLLEMILL VAEVGELKAN PDRLALGTVI EAQLDKGRGS 450
VATLLVQDGT LKVGDPIVVG HTFGRVRAMV NDKGRRVKEA GPSTPVEITG 500
LNDVPQAGDR FVVFEDEKTA RQVGETRAMS AIQAQRSEKQ RVTLDNLFEQ 550
MSQGEMKELN LIVKADVQGT VEAMAASLMK IDVEGVNVKI IHTGAGAITE 600
SDISLAAASN AIVIGFNVRP DVNAKRAAEE EGVDIRLHRI IYKVIEEIEQ 650
AMKGMLDPEF EEKIIGQAEV RQTIKVSKVG TIAGSYVTEG KVTRDSGVRV 700
IRDNVVIFEG ELDTLKRFKD EVKEVARGYE CGITITNFND IKEGDIIEAY 750
IMEEVKRV 758
Length:758
Mass (Da):83,264
Last modified:April 29, 2008 - v1
Checksum:i91E4CC40EF3546E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000817 Genomic DNA. Translation: ACA39196.1.
RefSeqiWP_012293304.1. NC_010382.1.
YP_001697326.1. NC_010382.1.

Genome annotation databases

EnsemblBacteriaiACA39196; ACA39196; Bsph_1598.
GeneIDi6021487.
KEGGilsp:Bsph_1598.
PATRICi22415693. VBILysSph89750_1713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000817 Genomic DNA. Translation: ACA39196.1 .
RefSeqi WP_012293304.1. NC_010382.1.
YP_001697326.1. NC_010382.1.

3D structure databases

ProteinModelPortali B1HR05.
SMRi B1HR05. Positions 532-651, 660-757.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444177.Bsph_1598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA39196 ; ACA39196 ; Bsph_1598 .
GeneIDi 6021487.
KEGGi lsp:Bsph_1598.
PATRICi 22415693. VBILysSph89750_1713.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi IYKAIDD.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci LSPH444177:GJEL-1639-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
    Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
    J. Bacteriol. 190:2892-2902(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C3-41.

Entry informationi

Entry nameiIF2_LYSSC
AccessioniPrimary (citable) accession number: B1HR05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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