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B1HNS5 (GUAC_LYSSC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase
EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:Bsph_4694
OrganismLysinibacillus sphaericus (strain C3-41) [Complete proteome] [HAMAP]
Taxonomic identifier444177 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Lysinibacillus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327GMP reductase HAMAP MF_01511
PRO_1000146140

Regions

Nucleotide binding204 – 22724NADP Potential

Sites

Active site1751Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
B1HNS5 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 67B12A87B933BF17

FASTA32735,680
        10         20         30         40         50         60 
MDNVFDYEDI QLIPAKCIVE SRSECDTSVT LGGHTFKLPV VPANMQTIID ETLAKKLAEN 

        70         80         90        100        110        120 
GYFYIMHRFQ PEARVNFIQD MHGSGLIASI SVGVKEEEYA FIEELAATNL VPEFITIDIA 

       130        140        150        160        170        180 
HGHSNAVIRM IQHIKKHLPN SFVIAGNVGT PEAVRELENA GADATKVGIG PGKVCITKIK 

       190        200        210        220        230        240 
TGFGTGGWQL AALRWCAKAA TKPIIADGGI RTHGDIAKSV RFGASMVMIG SLFAGHEESP 

       250        260        270        280        290        300 
GQTIEVEGKK VKEYFGSASE FQKGERKNVE GKKMFVEHKG SIKDTLIEMQ QDLQSSISYA 

       310        320 
GGTKLDAIRN VDYVIVKNSI FNGDKVY

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References

[1]"Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species."
Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M., Berry C., Yuan Z.
J. Bacteriol. 190:2892-2902(2008) [PubMed: 18296527] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C3-41.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000817 Genomic DNA. Translation: ACA42138.1.
RefSeqYP_001700268.1. NC_010382.1.

3D structure databases

ProteinModelPortalB1HNS5.
SMRB1HNS5. Positions 1-321.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1HNS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6022622.
GenomeReviewsGene locus Bsph_4694 in contig CP000817_GR.
KEGGlsp:Bsph_4694.
PATRIC22421905. VBILysSph89750_4770.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycLSPH444177:BSPH_4694-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_LYSSC
AccessionPrimary (citable) accession number: B1HNS5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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