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B1H3E1

- NLK2_XENTR

UniProt

B1H3E1 - NLK2_XENTR

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Protein
Serine/threonine-protein kinase NLK2
Gene
nlk.2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Negatively regulates Wnt/beta-catenin-signaling during development. Plays a role together with sox11 in neural induction during early embryogenesis. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 to phosphorylate stat3. Augments the rnf138/narf-directed ubiquitination and degradation of tcf/lef by enhancing the association of rnf138/narf and tcf/lef. Phosphorylates mef2a to play a role in anterior neural development, including eye formation By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961ATP By similarityBy similarity
Active sitei193 – 1931Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 819ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. MAP kinase activity Source: UniProtKB-EC
  3. magnesium ion binding Source: UniProtKB
  4. protein serine/threonine kinase activity Source: UniProtKB
  5. transcription factor binding Source: UniProtKB
  6. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. anterior/posterior pattern specification Source: UniProtKB
  3. mesoderm formation Source: UniProtKB
  4. nervous system development Source: UniProtKB
  5. peptidyl-serine phosphorylation Source: UniProtKB
  6. peptidyl-threonine phosphorylation Source: UniProtKB
  7. positive regulation of protein ubiquitination Source: UniProtKB
  8. regulation of transcription, DNA-templated Source: UniProtKB-KW
  9. serine phosphorylation of STAT3 protein Source: UniProtKB
  10. transcription, DNA-templated Source: UniProtKB-KW
  11. transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase NLK2 (EC:2.7.11.24)
Alternative name(s):
Nemo-like kinase 2
Short name:
Nlk.2
Gene namesi
Name:nlk.2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1218923. nlk.2.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Serine/threonine-protein kinase NLK2
PRO_0000370236Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with sox11, hmgxb4/hmg2l1, rnf138/narf, stat3.1 and mef2a By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB1H3E1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 356290Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 427Poly-Gly

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
KOiK04468.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1H3E1-1 [UniParc]FASTAAdd to Basket

« Hide

MAFQGPGRSL PGQLCAGVFG GLIQPPLGQK FYCPNGGSGG GGVPAVPSPL    50
PQALSAPQCN GDGRGEPEPD RPIGYGAFGV VWSVTDPRDG KRVALKKMPN 100
VFQNLVSCKR VFRELKMLCF FKHDNVLSAL DILQPPQIDC FEEIYVITEL 150
MQTDLHKVIV SPQPLSSDHI KVFLYQILRG LKYLHSAGIL HRDIKPGNLL 200
VNSNCVLKIC DFGLARVEEL DESQHMTQEV VTQYYRAPEI LMGSRHYRSA 250
IDIWSVGCIF AELLGRRILF QAQSPIQQLD LITDLLGTPP LTAMRSACEG 300
ARAHILRGPH KPPSLSVLYM LSGEATHEAV HLLCRMLLFD PLKRISAKDA 350
LAHPYLEEGR LRYHTCMCHC CYSVSSGRVY TADFEPTATN RFDDSYEKSL 400
TSVWQVKELV HRFITDQQQG KRPPLCINPH SAAFKTFIRS TAWHSSKVSK 450
KEER 454
Length:454
Mass (Da):50,652
Last modified:April 29, 2008 - v1
Checksum:i8DD61C2D6CCEEC4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC161361 mRNA. Translation: AAI61361.1.
RefSeqiNP_001116917.1. NM_001123445.1.
UniGeneiStr.64836.

Genome annotation databases

GeneIDi100144684.
KEGGixtr:100144684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC161361 mRNA. Translation: AAI61361.1 .
RefSeqi NP_001116917.1. NM_001123445.1.
UniGenei Str.64836.

3D structure databases

ProteinModelPortali B1H3E1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100144684.
KEGGi xtr:100144684.

Organism-specific databases

CTDi 398295.
Xenbasei XB-GENE-1218923. nlk.2.

Phylogenomic databases

eggNOGi COG0515.
KOi K04468.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neurula.

Entry informationi

Entry nameiNLK2_XENTR
AccessioniPrimary (citable) accession number: B1H3E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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