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B1H369 (HDAC8_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone deacetylase 8
Short name=HD8
EC=3.5.1.98
Gene names
Name:hdac8
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactor

Binds 1 divalent metal cation per subunit.

Enzyme regulation

Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Histone deacetylase 8
PRO_0000389511

Regions

Region5 – 316312Histone deacetylase By similarity

Sites

Active site1351Proton acceptor By similarity
Metal binding1701Divalent metal cation By similarity
Metal binding1721Divalent metal cation By similarity
Metal binding2591Divalent metal cation By similarity
Binding site931Substrate By similarity
Binding site1431Substrate; via carbonyl oxygen By similarity
Binding site2981Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B1H369 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 9ED5BBE73D188A75

FASTA36941,006
        10         20         30         40         50         60 
MEESLLPVYI HSAEYVELCD NVQSKVPRRA SMVHSLIEAY GLLKEMRVVK PKVASMEEMA 

        70         80         90        100        110        120 
AFHTDSYLQH LHKVSEEGDN DDPETLEYGL GYDCPITEGI YDYAAAVGGA TLTAAEQLMA 

       130        140        150        160        170        180 
GKTRIAINWP GGWHHAKKDE ASGFCYLNDA VLGILKLREK FDRVLYVDMD LHHGDGVEDA 

       190        200        210        220        230        240 
FSFTSKVMTV SLHKFSPGFF PGTGDVSDIG LGKGRYYSVN VPLQDGIQDE KYYQICEGVL 

       250        260        270        280        290        300 
KEVFTTFNPE AVVLQLGADT IAGDPMCSFN MTPQGIGKCL KYVLQWQLPT LILGGGGYHL 

       310        320        330        340        350        360 
PNTARCWTYL TALIVGRTLS SEIPDHEFFT EYGPDYVLEV TPSCRPDRND SQKVQEILQS 


IKGHLKQVV

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC161282 mRNA. Translation: AAI61282.1.
RefSeqNP_001120462.1. NM_001126990.1.
UniGeneStr.52530.

3D structure databases

ProteinModelPortalB1H369.
SMRB1H369. Positions 5-369.
ModBaseSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000044353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000044353; ENSXETP00000044353; ENSXETG00000020527.
GeneID100145561.
KEGGxtr:100145561.

Organism-specific databases

CTD55869.
XenbaseXB-GENE-5863426. hdac8.

Phylogenomic databases

eggNOGCOG0123.
GeneTreeENSGT00530000062889.
HOGENOMHOG000225180.
HOVERGENHBG057112.
KOK11405.
OMALLDQKCD.

Gene expression databases

BgeeB1H369.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameHDAC8_XENTR
AccessionPrimary (citable) accession number: B1H369
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: April 29, 2008
Last modified: April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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