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B1H369

- HDAC8_XENTR

UniProt

B1H369 - HDAC8_XENTR

Protein

Histone deacetylase 8

Gene

hdac8

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Cofactori

    Binds 1 divalent metal cation per subunit.

    Enzyme regulationi

    Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei93 – 931SubstrateBy similarity
    Active sitei135 – 1351Proton acceptorBy similarity
    Binding sitei143 – 1431Substrate; via carbonyl oxygenBy similarity
    Metal bindingi170 – 1701Divalent metal cationBy similarity
    Metal bindingi172 – 1721Divalent metal cationBy similarity
    Metal bindingi259 – 2591Divalent metal cationBy similarity
    Binding sitei298 – 2981SubstrateBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_207635. Separation of Sister Chromatids.
    REACT_214596. Resolution of Sister Chromatid Cohesion.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 8 (EC:3.5.1.98)
    Short name:
    HD8
    Gene namesi
    Name:hdac8
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5863426. hdac8.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Histone deacetylase 8PRO_0000389511Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiB1H369.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000044353.

    Structurei

    3D structure databases

    ProteinModelPortaliB1H369.
    SMRiB1H369. Positions 5-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni5 – 316312Histone deacetylaseBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00530000062889.
    HOGENOMiHOG000225180.
    HOVERGENiHBG057112.
    KOiK11405.
    OMAiCLIDGKC.
    OrthoDBiEOG722J95.
    TreeFamiTF106175.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    B1H369-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEESLLPVYI HSAEYVELCD NVQSKVPRRA SMVHSLIEAY GLLKEMRVVK    50
    PKVASMEEMA AFHTDSYLQH LHKVSEEGDN DDPETLEYGL GYDCPITEGI 100
    YDYAAAVGGA TLTAAEQLMA GKTRIAINWP GGWHHAKKDE ASGFCYLNDA 150
    VLGILKLREK FDRVLYVDMD LHHGDGVEDA FSFTSKVMTV SLHKFSPGFF 200
    PGTGDVSDIG LGKGRYYSVN VPLQDGIQDE KYYQICEGVL KEVFTTFNPE 250
    AVVLQLGADT IAGDPMCSFN MTPQGIGKCL KYVLQWQLPT LILGGGGYHL 300
    PNTARCWTYL TALIVGRTLS SEIPDHEFFT EYGPDYVLEV TPSCRPDRND 350
    SQKVQEILQS IKGHLKQVV 369
    Length:369
    Mass (Da):41,006
    Last modified:April 29, 2008 - v1
    Checksum:i9ED5BBE73D188A75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC161282 mRNA. Translation: AAI61282.1.
    RefSeqiNP_001120462.1. NM_001126990.1.
    UniGeneiStr.52530.

    Genome annotation databases

    EnsembliENSXETT00000044353; ENSXETP00000044353; ENSXETG00000020527.
    GeneIDi100145561.
    KEGGixtr:100145561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC161282 mRNA. Translation: AAI61282.1 .
    RefSeqi NP_001120462.1. NM_001126990.1.
    UniGenei Str.52530.

    3D structure databases

    ProteinModelPortali B1H369.
    SMRi B1H369. Positions 5-369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000044353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000044353 ; ENSXETP00000044353 ; ENSXETG00000020527 .
    GeneIDi 100145561.
    KEGGi xtr:100145561.

    Organism-specific databases

    CTDi 55869.
    Xenbasei XB-GENE-5863426. hdac8.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00530000062889.
    HOGENOMi HOG000225180.
    HOVERGENi HBG057112.
    KOi K11405.
    OMAi CLIDGKC.
    OrthoDBi EOG722J95.
    TreeFami TF106175.

    Enzyme and pathway databases

    Reactomei REACT_207635. Separation of Sister Chromatids.
    REACT_214596. Resolution of Sister Chromatid Cohesion.

    Gene expression databases

    Bgeei B1H369.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiHDAC8_XENTR
    AccessioniPrimary (citable) accession number: B1H369
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3