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B1H2Q2 (ZRAN1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin thioesterase zranb1
EC=3.4.19.12
Alternative name(s):
Zinc finger Ran-binding domain-containing protein 1
Gene names
Name:zranb1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length701 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The OTU domain mediates the deubiquitinating activity By similarity.

The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin By similarity.

Sequence similarities

Belongs to the peptidase C64 family.

Contains 2 ANK repeats.

Contains 1 OTU domain.

Contains 3 RanBP2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 701701Ubiquitin thioesterase zranb1
PRO_0000361558

Regions

Repeat253 – 28331ANK 1
Repeat306 – 33328ANK 2
Domain425 – 585161OTU
Zinc finger3 – 3331RanBP2-type 1
Zinc finger79 – 10830RanBP2-type 2
Zinc finger143 – 17331RanBP2-type 3

Sites

Active site4361Nucleophile By similarity
Active site5781Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
B1H2Q2 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: DD3A68A82AF3DADE

FASTA70180,037
        10         20         30         40         50         60 
MTEHGIKWAC EYCTYENWPS AIKCTMCRAP RPSGAIITEE PFKNSTPDVG SMERESGSPL 

        70         80         90        100        110        120 
ICPDSSARPR VKSSYSMETS TKWSCHMCTY LNWPRAIRCT QCLSQRRTRS PTESPQSSGS 

       130        140        150        160        170        180 
SLRAIPSPID PCEEYNDRNK LNIKGQHWTC SACTYENCAK AKKCVVCDHP TPNNMDAIEL 

       190        200        210        220        230        240 
ANTDEASSII NEQDRARWRG GCSSSNSQRR SPPTSKRDSD MDFQRIELAG AVGSKEEFEL 

       250        260        270        280        290        300 
DLKKLKQIKN RMRKTDWLFL NACVGVVEGD LSAVEAYKTS GGDIARQLSA DEVRLLNRPS 

       310        320        330        340        350        360 
AFDVGYTLVH LSIRFQRQDM LAILLTEFSQ HAAKCIPAMV CPELTEQIRR EIAASVHQRK 

       370        380        390        400        410        420 
GDFACYFLTD LVTFTLPADI EDLPPTVQEK LFDEVLDRDV QKELEEESPI INWSLELGTR 

       430        440        450        460        470        480 
LDSRLYALWN RTAGDCLLDS VLQATWGIYD KDSVLRKALH DSLHDCSHWF YSRWKEWESW 

       490        500        510        520        530        540 
YSQSFGLHFS LREEQWQEDW AFILSLASQP GASLEQTHIF VLAHILRRPI IVYGVKYYKS 

       550        560        570        580        590        600 
FRGETLGYTR FQGVYLPLLW EQSFCWKSPI ALGYTRGHFS ALVAMENDGF DNRGAGANLN 

       610        620        630        640        650        660 
TDDDVTVTFL PLVDSERKLL HIHFLSAQEL GNEDQQEKLL REWMDCCVTE GGVLVAMQKS 

       670        680        690        700 
SRRRNHPLVT QMVEKWLDGY RQIRPCTALS DGEEDEDDED E

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC161086 mRNA. Translation: AAI61086.1.
RefSeqNP_001116900.1. NM_001123428.1.
UniGeneStr.29069.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000050986.

Protein family/group databases

MEROPSC64.004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100144659.
KEGGxtr:100144659.

Organism-specific databases

CTD54764.
XenbaseXB-GENE-876399. zranb1.

Phylogenomic databases

eggNOGNOG253754.
HOGENOMHOG000006743.
HOVERGENHBG058978.
KOK11862.

Family and domain databases

InterProIPR003323. OTU.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamPF02338. OTU. 1 hit.
PF00641. zf-RanBP. 2 hits.
[Graphical view]
SMARTSM00547. ZnF_RBZ. 3 hits.
[Graphical view]
PROSITEPS50088. ANK_REPEAT. False negative.
PS50802. OTU. 1 hit.
PS01358. ZF_RANBP2_1. 3 hits.
PS50199. ZF_RANBP2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameZRAN1_XENTR
AccessionPrimary (citable) accession number: B1H2Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 29, 2008
Last modified: April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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