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B1H2Q2

- ZRAN1_XENTR

UniProt

B1H2Q2 - ZRAN1_XENTR

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Protein
Ubiquitin thioesterase zranb1
Gene
zranb1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei436 – 4361Nucleophile By similarity
Active sitei578 – 5781Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 3331RanBP2-type 1
Add
BLAST
Zinc fingeri79 – 10830RanBP2-type 2
Add
BLAST
Zinc fingeri143 – 17331RanBP2-type 3
Add
BLAST

GO - Molecular functioni

  1. ubiquitin thiolesterase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. cell migration Source: UniProtKB
  3. cytoskeleton organization Source: UniProtKB
  4. positive regulation of Wnt signaling pathway Source: UniProtKB
  5. protein K29-linked deubiquitination Source: UniProtKB
  6. protein K33-linked deubiquitination Source: UniProtKB
  7. protein K63-linked deubiquitination Source: UniProtKB
  8. regulation of cell morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC64.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin thioesterase zranb1 (EC:3.4.19.12)
Alternative name(s):
Zinc finger Ran-binding domain-containing protein 1
Gene namesi
Name:zranb1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-876399. zranb1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 701701Ubiquitin thioesterase zranb1
PRO_0000361558Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000050986.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati253 – 28331ANK 1
Add
BLAST
Repeati306 – 33328ANK 2
Add
BLAST
Domaini425 – 585161OTU
Add
BLAST

Domaini

The OTU domain mediates the deubiquitinating activity By similarity.
The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin By similarity.

Sequence similaritiesi

Belongs to the peptidase C64 family.
Contains 2 ANK repeats.
Contains 1 OTU domain.

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG253754.
HOGENOMiHOG000006743.
HOVERGENiHBG058978.
KOiK11862.

Family and domain databases

InterProiIPR003323. OTU.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
PF00641. zf-RanBP. 2 hits.
[Graphical view]
SMARTiSM00547. ZnF_RBZ. 3 hits.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
PS01358. ZF_RANBP2_1. 3 hits.
PS50199. ZF_RANBP2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1H2Q2-1 [UniParc]FASTAAdd to Basket

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MTEHGIKWAC EYCTYENWPS AIKCTMCRAP RPSGAIITEE PFKNSTPDVG    50
SMERESGSPL ICPDSSARPR VKSSYSMETS TKWSCHMCTY LNWPRAIRCT 100
QCLSQRRTRS PTESPQSSGS SLRAIPSPID PCEEYNDRNK LNIKGQHWTC 150
SACTYENCAK AKKCVVCDHP TPNNMDAIEL ANTDEASSII NEQDRARWRG 200
GCSSSNSQRR SPPTSKRDSD MDFQRIELAG AVGSKEEFEL DLKKLKQIKN 250
RMRKTDWLFL NACVGVVEGD LSAVEAYKTS GGDIARQLSA DEVRLLNRPS 300
AFDVGYTLVH LSIRFQRQDM LAILLTEFSQ HAAKCIPAMV CPELTEQIRR 350
EIAASVHQRK GDFACYFLTD LVTFTLPADI EDLPPTVQEK LFDEVLDRDV 400
QKELEEESPI INWSLELGTR LDSRLYALWN RTAGDCLLDS VLQATWGIYD 450
KDSVLRKALH DSLHDCSHWF YSRWKEWESW YSQSFGLHFS LREEQWQEDW 500
AFILSLASQP GASLEQTHIF VLAHILRRPI IVYGVKYYKS FRGETLGYTR 550
FQGVYLPLLW EQSFCWKSPI ALGYTRGHFS ALVAMENDGF DNRGAGANLN 600
TDDDVTVTFL PLVDSERKLL HIHFLSAQEL GNEDQQEKLL REWMDCCVTE 650
GGVLVAMQKS SRRRNHPLVT QMVEKWLDGY RQIRPCTALS DGEEDEDDED 700
E 701
Length:701
Mass (Da):80,037
Last modified:April 29, 2008 - v1
Checksum:iDD3A68A82AF3DADE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC161086 mRNA. Translation: AAI61086.1.
RefSeqiNP_001116900.1. NM_001123428.1.
UniGeneiStr.29069.

Genome annotation databases

GeneIDi100144659.
KEGGixtr:100144659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC161086 mRNA. Translation: AAI61086.1 .
RefSeqi NP_001116900.1. NM_001123428.1.
UniGenei Str.29069.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000050986.

Protein family/group databases

MEROPSi C64.004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100144659.
KEGGi xtr:100144659.

Organism-specific databases

CTDi 54764.
Xenbasei XB-GENE-876399. zranb1.

Phylogenomic databases

eggNOGi NOG253754.
HOGENOMi HOG000006743.
HOVERGENi HBG058978.
KOi K11862.

Family and domain databases

InterProi IPR003323. OTU.
IPR001876. Znf_RanBP2.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
PF00641. zf-RanBP. 2 hits.
[Graphical view ]
SMARTi SM00547. ZnF_RBZ. 3 hits.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
PS01358. ZF_RANBP2_1. 3 hits.
PS50199. ZF_RANBP2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZRAN1_XENTR
AccessioniPrimary (citable) accession number: B1H2Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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