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Protein
Submitted name:

Intramembrane protease 5

Gene

Sppl2c

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Protein family/group databases

MEROPSiA22.006.

Names & Taxonomyi

Protein namesi
Submitted name:
Intramembrane protease 5Imported
Submitted name:
Similar to intramembrane protease 5 (Predicted)Imported
Gene namesi
Name:Sppl2cImported
Synonyms:Imp5Imported, RGD1560562_predictedImported
ORF Names:rCG_35591Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1560562. Sppl2c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei285 – 306HelicalSequence analysisAdd BLAST22
Transmembranei327 – 346HelicalSequence analysisAdd BLAST20
Transmembranei352 – 369HelicalSequence analysisAdd BLAST18
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei446 – 464HelicalSequence analysisAdd BLAST19
Transmembranei476 – 499HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500875512025 – 691Sequence analysisAdd BLAST667

Expressioni

Gene expression databases

BgeeiENSRNOG00000005104.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066080.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 162PA (protease associated)InterPro annotationAdd BLAST72

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2442. Eukaryota.
ENOG410ZP52. LUCA.
HOVERGENiHBG024193.
KOiK14212.
OrthoDBiEOG091G05NG.

Family and domain databases

InterProiIPR003137. PA_domain.
IPR007369. Peptidase_A22B_SPP.
IPR006639. Preselin/SPP.
IPR033150. SPPL2C.
[Graphical view]
PANTHERiPTHR12174. PTHR12174. 2 hits.
PTHR12174:SF38. PTHR12174:SF38. 2 hits.
PfamiPF02225. PA. 1 hit.
PF04258. Peptidase_A22B. 1 hit.
[Graphical view]
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1H292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLGSLLPI GSLLLLLLSP EARGEYGVVR VVSKNWNKDY CVLYSSDYVT
60 70 80 90 100
LPRDLSHAPL LPLHDGTKTP WCPDEDSFHQ AQDSSLSQRP LHQTTTMVVR
110 120 130 140 150
GNCSFYAKGW LAQDHGAHGL LIVSRASNQQ CSDTTSKPQD PSKPRPALTI
160 170 180 190 200
PVAVLRYTDM LDILSHTYGD TNVHIAMYAP LEPIIDYNMV IIFILAVGTV
210 220 230 240 250
AAGGYWAGLM EADRLQRHQA RRGGGFGGHN QSQTVSAERS PRAWKEEDYE
260 270 280 290 300
DAAVDFTPAM TGAVVTMSCS IMVLLYFFYD CFVYIMIGIF GLGASTGLYS
310 320 330 340 350
CLAPIVRYLP LWQHQWVLPG HRASVKLSLL LLAGLCAMVT VLWVIYRNED
360 370 380 390 400
RWAWLLQDTL GVAYCLFVLR RVRLPTLKNC TSFLLALLAF DVFFVFITPL
410 420 430 440 450
FTKTGESIMV EVASGPVDSS SHERLPMVLK VPRMSFSALT LCDQPFSILG
460 470 480 490 500
FGDIVVPGFL VAYCHRFDVQ IQSRQVYYRA CTVAYAMGLL VTFVAMVLMQ
510 520 530 540 550
MGQPALLYLV SSTLLTSLVV ATCRQELTLF WTGQGRAKIP AEPVVQPCIV
560 570 580 590 600
SAVACRMKLE GVKDSRVTNR FEEAIDRESG DLDSNPGDDI AEMVTLSEDE
610 620 630 640 650
ATSPEGHSES SEGWSDTNLD PDELPSGSPM ALEELMPLAM LIPLIPPIPH
660 670 680 690
TSELGRIHTQ SRVRDSSLPW MGMHKRKGLK VKKSMSTQAP L
Length:691
Mass (Da):76,416
Last modified:April 29, 2008 - v1
Checksum:i58A733D854160FAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC160911 mRNA. Translation: AAI60911.1.
CH473948 Genomic DNA. Translation: EDM06295.1.
RefSeqiNP_001099317.1. NM_001105847.1.
UniGeneiRn.108313.

Genome annotation databases

GeneIDi287753.
KEGGirno:287753.
UCSCiRGD:1560562. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC160911 mRNA. Translation: AAI60911.1.
CH473948 Genomic DNA. Translation: EDM06295.1.
RefSeqiNP_001099317.1. NM_001105847.1.
UniGeneiRn.108313.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066080.

Protein family/group databases

MEROPSiA22.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi287753.
KEGGirno:287753.
UCSCiRGD:1560562. rat.

Organism-specific databases

CTDi162540.
RGDi1560562. Sppl2c.

Phylogenomic databases

eggNOGiKOG2442. Eukaryota.
ENOG410ZP52. LUCA.
HOVERGENiHBG024193.
KOiK14212.
OrthoDBiEOG091G05NG.

Gene expression databases

BgeeiENSRNOG00000005104.

Family and domain databases

InterProiIPR003137. PA_domain.
IPR007369. Peptidase_A22B_SPP.
IPR006639. Preselin/SPP.
IPR033150. SPPL2C.
[Graphical view]
PANTHERiPTHR12174. PTHR12174. 2 hits.
PTHR12174:SF38. PTHR12174:SF38. 2 hits.
PfamiPF02225. PA. 1 hit.
PF04258. Peptidase_A22B. 1 hit.
[Graphical view]
SMARTiSM00730. PSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1H292_RAT
AccessioniPrimary (citable) accession number: B1H292
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 30, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.