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Protein

Kelch repeat and BTB domain-containing protein 8

Gene

Kbtbd8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 8By similarity
Gene namesi
Name:Kbtbd8Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1563166. Kbtbd8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003935701 – 575Kelch repeat and BTB domain-containing protein 8Add BLAST575

Proteomic databases

PaxDbiB1H285.
PRIDEiB1H285.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013390.

Interactioni

Protein-protein interaction databases

BioGridi271570. 1 interactor.
STRINGi10116.ENSRNOP00000017889.

Structurei

3D structure databases

ProteinModelPortaliB1H285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 91BTBPROSITE-ProRule annotationAdd BLAST69
Domaini126 – 228BACKSequence analysisAdd BLAST103
Repeati310 – 364Kelch 1Sequence analysisAdd BLAST55
Repeati365 – 415Kelch 2Sequence analysisAdd BLAST51
Repeati417 – 455Kelch 3Sequence analysisAdd BLAST39
Repeati457 – 506Kelch 4Sequence analysisAdd BLAST50
Repeati516 – 562Kelch 5Sequence analysisAdd BLAST47

Sequence similaritiesi

Contains 1 BACK (BTB/Kelch associated) domain.Sequence analysis
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Sequence analysis

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
HOGENOMiHOG000113200.
HOVERGENiHBG100857.
InParanoidiB1H285.
KOiK10475.
PhylomeDBiB1H285.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR028764. KBTBD8.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF24. PTHR24412:SF24. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1H285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFHACSIL KQLKTMYDEG QLTDIVVEVD HGKTFSCHRN VLAAISPYFR
60 70 80 90 100
SMFTSGLTES TQKEVRIIGV EAESMGLVLN YAYTSRVILT EANVQALFTT
110 120 130 140 150
ASIFQIPSIQ DQCAKYMISH LDPQNSIGVF IFADHYGHQE LGDRSKEYIR
160 170 180 190 200
KKFLCVTKEQ EFLQLTKDQL ISILDSDDLN VDREEHVYES IIRWFEHEQN
210 220 230 240 250
EREVHLPEIF AKCIRFPLME DAFIEKIPPR FAQAIVKSCG EKGPSNTNGC
260 270 280 290 300
TQRLGMTASE MIICFDAAHK HSGKKQTVPC LDIVTGRVFK LCKPPNDLRE
310 320 330 340 350
VGILVSPDND IYIAGGYRPS SSEVSIDHKA ENDFWMYDHS TNRWLSKPSL
360 370 380 390 400
LRARIGCKLV YCCGKMYAIG GRVYEGDGRN SLKSVECYDS RENCWMTVCA
410 420 430 440 450
MPVAMEFHNA VEHKEKIYVL QGEFFLFYEP QKDYWGFLTP MTVPRIQGLA
460 470 480 490 500
AVYKDSIYYI AGTCGNHQRV FTVEAYDIEL NKWTRKKDFP CDQSINPYLK
510 520 530 540 550
LVLFQNKLHL FVRATQVTVE EHIFRTSRKN SLYQYDDIAD QWMKVYETPD
560 570
RLWDLGRHFE CAVAKLYPQC LQKVL
Length:575
Mass (Da):66,322
Last modified:April 29, 2008 - v1
Checksum:iFD0F72C893554CC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473957 Genomic DNA. Translation: EDL91413.1.
BC160902 mRNA. Translation: AAI60902.1.
RefSeqiNP_001102720.2. NM_001109250.3.
XP_006236994.1. XM_006236932.2.
UniGeneiRn.219562.

Genome annotation databases

GeneIDi500262.
KEGGirno:500262.
UCSCiRGD:1563166. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473957 Genomic DNA. Translation: EDL91413.1.
BC160902 mRNA. Translation: AAI60902.1.
RefSeqiNP_001102720.2. NM_001109250.3.
XP_006236994.1. XM_006236932.2.
UniGeneiRn.219562.

3D structure databases

ProteinModelPortaliB1H285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi271570. 1 interactor.
STRINGi10116.ENSRNOP00000017889.

Proteomic databases

PaxDbiB1H285.
PRIDEiB1H285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi500262.
KEGGirno:500262.
UCSCiRGD:1563166. rat.

Organism-specific databases

CTDi84541.
RGDi1563166. Kbtbd8.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
HOGENOMiHOG000113200.
HOVERGENiHBG100857.
InParanoidiB1H285.
KOiK10475.
PhylomeDBiB1H285.

Miscellaneous databases

PROiB1H285.

Gene expression databases

BgeeiENSRNOG00000013390.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR028764. KBTBD8.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF24. PTHR24412:SF24. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKBTB8_RAT
AccessioniPrimary (citable) accession number: B1H285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.