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Protein

PWWP domain-containing protein MUM1

Gene

Mum1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
PWWP domain-containing protein MUM1
Alternative name(s):
Mutated melanoma-associated antigen 1
Short name:
MUM-1
Gene namesi
Name:Mum1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1308340. Mum1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698PWWP domain-containing protein MUM1PRO_0000375870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051PhosphoserineBy similarity
Modified residuei165 – 1651PhosphoserineCombined sources
Modified residuei168 – 1681PhosphoserineCombined sources
Modified residuei170 – 1701PhosphoserineCombined sources
Modified residuei355 – 3551PhosphoserineBy similarity
Modified residuei356 – 3561PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB1H224.
PRIDEiB1H224.

PTM databases

iPTMnetiB1H224.
PhosphoSiteiB1H224.

Expressioni

Gene expression databases

GenevisibleiB1H224. RN.

Interactioni

Subunit structurei

Interacts with TP53BP1 (via BRCT domain); the interaction is not dependent on its phosphorylation status. Binds nucleosomes. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3) (in vitro) (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB1H224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini399 – 46062PWWPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi281 – 34969Pro-richAdd
BLAST

Domaini

The PWWP domain mediates the interaction with nucleosomes.

Sequence similaritiesi

Belongs to the MUM1 family.Curated
Contains 1 PWWP domain.Curated

Phylogenomic databases

eggNOGiENOG410IKQG. Eukaryota.
ENOG4111FZN. LUCA.
GeneTreeiENSGT00390000001700.
HOGENOMiHOG000232141.
InParanoidiB1H224.
OMAiQAIGWCV.
OrthoDBiEOG7BS494.
PhylomeDBiB1H224.
TreeFamiTF328774.

Family and domain databases

InterProiIPR033368. MUM1.
[Graphical view]
PANTHERiPTHR31333:SF4. PTHR31333:SF4. 1 hit.

Sequencei

Sequence statusi: Complete.

B1H224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAKYVLCR WEKRLWPAKV LARTETSAKN KRKKEFFLDV QILSLKEKIQ
60 70 80 90 100
VKSSAVEALQ KSHIENIAAF LASQNEVPAT PLEELTYRRS LRVALDVLNE
110 120 130 140 150
RTSLSPESHP VENGSTPSQK GKPDADMASQ VSSAPSPSFL SEDDQAVAAQ
160 170 180 190 200
CASKRRWECS PKSLSPLSAS EEDLRCKVDP KTGLSESGAL GTEVPAPTGD
210 220 230 240 250
ESQNGSGSQL DHGQESTTKK RQRNSGEKPA RRGKAESGLS KGDSVAESGG
260 270 280 290 300
QASSCVALAS PRLPSQTWEG DPCAGVEGCD PVESSGNIRP LLDSERSKGR
310 320 330 340 350
LTKRPRLDGG RNPLPRHLGT RTVGAVPSRR SCSGEVTTLR RAGDSDRPEE
360 370 380 390 400
ADPMSSEEST GFKSVHSLLE EEEEEEEEEE EEEEPPRILL YHEPRSFEVG
410 420 430 440 450
MLVWLKYQKY PFWPAVVKSV RRRDKKASVL FIEGNMNPKG RGITVSLRRL
460 470 480 490 500
KHFDCKEKHA LLDRAKEDFA QAIGWCVSLI TDYRVRLGCG SFAGSFLEYY
510 520 530 540 550
AADISYPVRK SIQQDVLGTR FPQLGKGDPE EPMGDSRLGQ WRPCRKVLPD
560 570 580 590 600
RSRAARDKAN QKLVEYIVKA KGAESHLRAI LHSRKPSRWL KTFLSSNQYV
610 620 630 640 650
TCMETYLEDE AQLDEVVEYL QGVCRDMDGE MPARGSGDRI RFILDVLLPE
660 670 680 690
AIICAISAVE AVDYKTAEQK YLRGPTLSYR EKEIFDNELL EERNRRRR
Length:698
Mass (Da):77,974
Last modified:April 29, 2008 - v1
Checksum:i5F5E838911B971D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC160828 mRNA. Translation: AAI60828.1.
RefSeqiXP_006241035.1. XM_006240973.2.
XP_006241036.1. XM_006240974.2.
XP_006241037.1. XM_006240975.2.
UniGeneiRn.92148.

Genome annotation databases

EnsembliENSRNOT00000060708; ENSRNOP00000057438; ENSRNOG00000024549.
GeneIDi362838.
UCSCiRGD:1308340. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC160828 mRNA. Translation: AAI60828.1.
RefSeqiXP_006241035.1. XM_006240973.2.
XP_006241036.1. XM_006240974.2.
XP_006241037.1. XM_006240975.2.
UniGeneiRn.92148.

3D structure databases

ProteinModelPortaliB1H224.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiB1H224.
PhosphoSiteiB1H224.

Proteomic databases

PaxDbiB1H224.
PRIDEiB1H224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000060708; ENSRNOP00000057438; ENSRNOG00000024549.
GeneIDi362838.
UCSCiRGD:1308340. rat.

Organism-specific databases

CTDi84939.
RGDi1308340. Mum1.

Phylogenomic databases

eggNOGiENOG410IKQG. Eukaryota.
ENOG4111FZN. LUCA.
GeneTreeiENSGT00390000001700.
HOGENOMiHOG000232141.
InParanoidiB1H224.
OMAiQAIGWCV.
OrthoDBiEOG7BS494.
PhylomeDBiB1H224.
TreeFamiTF328774.

Miscellaneous databases

PROiB1H224.

Gene expression databases

GenevisibleiB1H224. RN.

Family and domain databases

InterProiIPR033368. MUM1.
[Graphical view]
PANTHERiPTHR31333:SF4. PTHR31333:SF4. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-168 AND SER-170, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMUM1_RAT
AccessioniPrimary (citable) accession number: B1H224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: April 29, 2008
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.